University of Huddersfield Logo

Portrait of Professor Michael Page Professor Michael Page

m.i.page@hud.ac.uk | 01484 472534



Biography

Mike Page studied Chemistry at the now University of Brighton in 1967 and completed his PhD at the universities of Leicester and Glasgow in 1970. He worked as a postdoctoral research fellow with Professor W P Jencks in the United States between 1970 and 1972 and then with Professor R P Bell in 1972-1973. He was then appointed Lecturer at the now University of Huddersfield where he has been Senior Lecturer, Principal Lecturer, Reader and then Professor in 1985. Mike was Head of the Department of Chemical and Biological Sciences from 1985 until 1997 and Dean of the School of Applied Sciences from 1989 to 2003. He also acted as Dean of Research from 1987-2003. He went on to become the University’s Deputy Vice-Chancellor with responsibility for planning, resources and research, from which he retired in 2009. He was awarded the honorary emeritus professorship by the University the following year and became the first recipient of a new award, Doctor of the University to add to his existing two DSc awards. Since then, Mike has remained an active researcher and is Director of the research unit IPOS. He was recently asked to take up the position of Acting Dean of the School of Applied Sciences as an interim appointment.

Mike Page has been a member of BBSRC and EPSRC committees, including BioMolecular Sciences, Molecular Recognition, chemistry and organic chemistry. He has represented the UK on international committees such as European Union committees and IUPAC. He was Chairman of the Committee of Heads of Polytechnic Chemistry Departments and a member of the CNAA Chemistry Board. He was Chairman of the Royal Society of Chemistry (RSC) Qualifications and Education Board and a member of the Council and a member of several other RSC committees. He is currently Chair of the RSC Disciplinary Committee and member of the Chemistry Biology Interface Division committee. He was a member of the HEFCE Research Assessment Exercise panel for Chemistry in 1992 and was a member of the HEFCE pilot teaching assessment of chemistry. He has been Chairman of the RSC Organic Reaction Mechanisms Group and a member of the Editorial Boards of Chemical Communications, JCS Perkin 2, Natural Products, Biochemical Journal and J. Phys. Org. Chem.

He was awarded the RSC Perkin Transactions 150th Anniversary Prize 1991; RSC Organic Reaction Mechanisms 2003 and SCI R&D for Society Award 2010. Mike Page has published over 200 research papers and supervised over 50 PhD students. He has edited books on The Chemistry of Enzyme Action (Elsevier 1984), Enzyme Mechanisms (Roy. Soc. Chem. 1987) and The Chemistry of β-Lactam Antibiotics (Blackie 1992). He recently co-authored, with Andrew Williams, a postgraduate book on Organic and BioOrganic Mechanisms (Longman 1997). Mike has given many international plenary lectures and contributed many papers at symposia world-wide.

Mike has worked closely with industry, particularly the pharmaceutical sector and has had colloborative research projects with AstraZeneca, GlaxoSmithKline, Avecia, Syngenta, James Robinson, British Biotech, ICI Pharm., Fisons, PanTherix, Proteus and NPilPharma.

Research & Scholarship

His main areas of research interest are:

  • The chemistry of β-lactam antibiotics and their derivatives
  • The mechanism of β-lactamase, proteases and enzyme catalysed reactions
  • Enzymes in synthesis - enantioselective biotransformations
  • Rationalisation of enzyme catalytic power and enzyme specificity
  • Drug design - enzyme inhibitors
  • Kinetics and mechanisms in organic and biochemistry
  • Intramolecular reactions
  • Proton transfer
  • Metal-ion and micelle catalysed reactions
  • Enantioselective synthesis

These areas of research are inter-related by the theme of the mechanisms of reactions.

Publications and Other Research Outputs

2014

Motara, H., Mistry, D., Brown, D., Cryan, R., Nigen, M. and Page, M. (2014) ‘pH and basicity of ligands control the binding of metal-ions to B. cereus B1 ?-lactamaseChemical Science , 5 (8), pp. 3120-3129. ISSN 2041-6520

Sun, H., Page, M., Atherton, J. and Hall, A. (2014) ‘Kinetics of the conversion of methyl benzoate to benzamide by the alumina catalysed reaction with liquid ammonia at 120 °CCatalysis Science & Technology . ISSN 2044-4753

2013

Mistry, D., Powles, N. and Page, M. (2013) ‘Unusual stability and carbon acidity of a dicationic carbon speciesThe Journal of Organic Chemistry , 78 (21), pp. 10732-10736. ISSN 0022-3263

Atherton, J., Page, M. and Sun, H. (2013) ‘Reaction kinetics in liquid ammonia up to 120C: techniques and some solvolysis and substitution reactionsJournal of Physical Organic Chemistry . ISSN 1099-1395

2012

Ji, P., Atherton, J. and Page, M. (2012) ‘Copper catalysed azide–alkyne cycloaddition (CuAAC) in liquid ammoniaOrganic & Biomolecular Chemistry , 10 (39), pp. 7965-7969. ISSN 1477-0520

Ji, P., Atherton, J. and Page, M. (2012) ‘Copper(I)-Catalyzed Amination of Aryl Halides in Liquid AmmoniaThe Journal of Organic Chemistry , 77 (17), pp. 7471-7478. ISSN 0022-3263

Fink, A. and Page, M. (2012) ‘The mechanisms of catalysis by ?-lactamases ’. In: ?-Lactamases. New York, USA: Nova Science. pp. 161-198. ISBN 978-1-61324-638-2

Powles, N., Atherton, J. and Page, M. (2012) ‘Reactive intermediates in the H-phosphonate synthesis of oligonucleotidesOrganic and Biomolecular Chemistry , 10 (30), pp. 5940-5947. ISSN 1477-0539

Ji, P., Atherton, J. and Page, M. (2012) ‘Organic reactivity in liquid ammoniaOrganic & Biomolecular Chemistry , 10 (30), pp. 5732-5739. ISSN 1477-0520

2011

Ji, P., Powles, N., Atherton, J. and Page, M. (2011) ‘Ionization of Carbon Acids in Liquid AmmoniaOrganic Letters , 13 (22), pp. 6118-6121. ISSN 1523-7060

Ji, P., Atherton, J. and Page, M. (2011) ‘The Kinetics and Mechanisms of Aromatic Nucleophilic Substitution Reactions in Liquid AmmoniaThe Journal of Organic Chemistry , 76 (9), pp. 3286-3295. ISSN 00223263

Ward, R., Lallemand, F., de Witte, P., Crichton, R., Piette, J., Tipton, K., Hemmings, K., Pitard, A., Page, M. and Corte, L. (2011) ‘Anti-inflammatory actions of a taurine analogue, ethane ?-sultam, in phagocytic cells, in vivo and in vitroBiochemical Pharmacology , 81 (6), pp. 743-751. ISSN 0006-2952

Ji, P., Atherton, J. and Page, M. (2011) ‘Liquid Ammonia as a Dipolar Aprotic Solvent for Aliphatic Nucleophilic Substitution ReactionsThe Journal of Organic Chemistry , 76 (5), pp. 1425-1435. ISSN 00223263

Ward, R., Lallemand, F., de Witte, P., Chrichton, R., Piette, J., Tipton, K., Hemming, K., Pitard, A., Page, M., Corte, L., Taylor, D. and Dexter, D. (2011) ‘Anti-inflammatory actions of a taurine analogue - ethane beta-sultamBiochemical Pharmacology , 81 (6), pp. 743-751. ISSN 0006-2952

2010

Page, M (2010) ‘Structure and reactivity of ?-lactams’. In: Amino Acids, Peptides and Proteins in Organic Chemistry: Building Blocks, Catalysis and Coupling Chemistry . London, UK: Wiley. pp. 169-200. ISBN 978-3-527-32102-5

Ji, P., Atherton, J. and Page, M. (2010) ‘The kinetics and mechanisms of organic reactions in liquid ammoniaFaraday Discussions , 145, pp. 15-25. ISSN 1359-6640

2009

Russell, M., Laws, A., Atherton, J. and Page, M. (2009) ‘The kinetics and mechanism of the acid-catalysed detritylation of nucleotides in non-aqueous solutionOrganic and Biomolecular Chemistry , 7 (1), pp. 52-57. ISSN 1477-0539

2008

Badarau, A. and Page, M. (2008) ‘Loss of enzyme activity during turnover of the Bacillus cereus ?-lactamase catalysed hydrolysis of ?-lactams due to loss of zinc ionJBIC Journal of Biological Inorganic Chemistry , 13 (6), pp. 919-928. ISSN 09498257

Russell, M., Laws, A., Atherton, J. and Page, M. (2008) ‘The mechanism of the phosphoramidite synthesis of polynucleotidesOrganic and Biomolecular Chemistry , 6 (18), pp. 3270-3275. ISSN 1477-0539

Tsang, W., Ahmed, N., Hemming, K. and Page, M. (2008) ‘An activated sulfonylating agent that undergoes general base-catalyzed hydrolysis by amines in preference to aminolysisThe Journal of Organic Chemistry , 73 (12), pp. 4504-4512. ISSN 00223263

Mulchande, J., Guedes, R., Tsang, W., Page, M., Moreira, R. and Iley, J. (2008) ‘Azetidine-2,4-diones (4-Oxo-?-lactams) as Scaffolds for Designing Elastase InhibitorsJournal of Medicinal Chemistry , 51 (6), pp. 1783-1790. ISSN 0022-2623

Page, M. and Badarau, A. (2008) ‘The Mechanisms of Catalysis by Metallo ?-LactamasesBioinorganic Chemistry and Applications , 2008, pp. 1-14. ISSN 1565-3633

2007

Tsang, W., Ahmed, N., Hemming, K. and Page, M. (2007) ‘Reactivity and selectivity in the inhibition of elastase by 3-oxo-?-sultams and in their hydrolysisOrganic and Biomolecular Chemistry , 5 (24), pp. 3993-4000. ISSN 1477-0539

Stirling, M., Blacker, J. and Page, M. (2007) ‘Chemoenzymatic dynamic kinetic resolution of secondary amines Tetrahedron Letters , 48 (7), pp. 1247-1250. ISSN 0040-4039

Hanusek, J., Russell, M., Laws, A. and Page, M. (2007) ‘Evidence for the formation of isothiocyanate during sulphurisation of triphenyl phosphines using xanthane hydride Tetrahedron Letters , 48 (3), pp. 417-419. ISSN 0040-4039

Tsang, W., Ahmed, N. and Page, M. (2007) ‘The aminolysis of N-Aroyl ?-Lactams occurs by a concerted mechanism Organic and Biomolecular Chemistry , 5 (3), pp. 485-493. ISSN 1477-0539

Badarau, A., Damblon, C. and Page, M. (2007) ‘The activity of the dinuclear cobalt-?-lactamase from bacillus cereus in catalysing the hydrolysis of ?-lactams Biochemical Journal , 401, pp. 197-203. ISSN 0264-6021

Hanusek, J., Russell, M., Laws, A., Jansa, P., Atherton, J., Fettes, K. and Page, M. (2007) ‘Mechanism of the sulphurisation of phosphines and phosphites using 3-amino-1,2,4-dithiazole-5-thione (Xanthane Hydride) Organic and Biomolecular Chemistry , 5 (3), pp. 478-484. ISSN 1477-0539

Blacker, A., Stirling, M. and Page, M. (2007) ‘Catalytic racemisation of chiral amines and application in dynamic kinetic resolutionOrganic Process Research and Development , 11 (3), pp. 642-648. ISSN 1083-6160

2006

Hemming, K., O'Gorman, P. and Page, M. (2006) ‘The synthesis of azabicyclo[4.2.1]nonenes by the addition of a cyclopropenone to 4-vinyl substituted 1-azetines-isomers of the homotropane nucleusTetrahedron Letters , 47, pp. 425-428. ISSN 0040-4039

Badarau, A. and Page, M. (2006) ‘The variation of catalytic efficiency of bacillus cereus metallo- ?-lactamase with different active site metal ions Biochemistry , 45 (35), pp. 10654-10666. ISSN 1520-4995

Badarau, A. and Page, M. (2006) ‘Enzyme deactivation due to metal-ion dissociation during turnover of the cobalt ?-lactamase catalysed hydrolysis of ?-lactamsBiochemistry , 45 (35), pp. 11012-11020. ISSN 0006-2960

Page, M., Tsang, W. and Ahmed, N. (2006) ‘Comparison of the mechanisms of reactions of ?-Lactams and ?-Sultams including their reactions with some serine enzymes Journal of Physical Organic Chemistry , 19 (8-9), pp. 446-451. ISSN 1099-1395

2005

Tsang, W., Ahmed, N., Hemming, K. and Page, M. (2005) ‘Competitive endo- and exo-cyclic C-N fission in the hydrolysis of N-aroyl ?-lactams Canadian Journal of Chemistry , 83 (9), pp. 1432-1439. ISSN 1480-3291

Llinas, A., Ahmed, N., Cordaro, M., Laws, A., Frere, J., Delmarcelle, M., Silvaggi, N., Kelly, J. and Page, M. (2005) ‘The inactivation of bacterial DD-peptidase by ?-sultams Biochemistry , 44 (21), pp. 7738-7746. ISSN 1520-4995

Badarau, A., Llinas, A., Laws, A., Damblon, C. and Page, M. (2005) ‘Inhibitors of metallo-?-lactamase generated from ?-lactam antibiotics Biochemistry , 44 (24), pp. 8578-8589. ISSN 1520-4995

Tsang, W., Ahmed, N., Harding, L., Hemming, K., Laws, A. and Page, M. (2005) ‘Acylation versus sulfonylation in the inhibition of elastase by 3-oxo-beta-sultams Journal of the American Chemical Society , 127 (25), pp. 8946-8947. ISSN 1520-5126

Tsang, W., Ahmed, N., Hinchliffe, P., Wood, J., Harding, L., Laws, A. and Page, M. (2005) ‘Different transition-state structures for the reactions of ?-lactams and analogous ?-sultams with serine ?-lactamases Journal of the American Chemical Society , 127 (49), pp. 17556-17564. ISSN 1520-5126

2004

Llinas, A., Vilanova, B. and Page, M. (2004) ‘The thiol catalysed hydrolysis of cephalosporins and possible rate-limiting amine anion expulsion Journal of Physical Organic Chemistry , 17 (6-7), pp. 521-528. ISSN 1099-1395

Tsang, W., Dhanda, A., Schofield, C., Frere, J., Galleni, M. and Page, M. (2004) ‘The inhibition of metallo-?-lactamase by thioxo-cephalosporin derivatives Bioorganic & Medicinal Chemistry Letters , 14 (7), pp. 1737-1739. ISSN 0960-894X

Page, M (2004) ‘?-sultams-mechanism of reactions and use as inhibitors of serine proteases Accounts of Chemical Research , 37 (5), pp. 297-303. ISSN 0001-4842

Llinas, A. and Page, M. (2004) ‘Intramolecular general acid catalysis in the aminolysis of ?-lactam antibiotics Organic and Biomolecular Chemistry , 2, pp. 651-654. ISSN 1477-0539

Ahmed, N., Tsang, W. and Page, M. (2004) ‘Acyl vs Sulfonyl Transfer in N-Acyl ?-Sultams and 3-Oxo-? sultams Organic Letters , 6 (2), pp. 201-203. ISSN 15237060

Tsang, W., Dhanda, A., Schofield, C. and Page, M. (2004) ‘Kinetics and mechanisms of hydrolysis and aminolysis of thioxocephalosporinsThe Journal of Organic Chemistry , 69 (2), pp. 339-344. ISSN 00223263

2003

Page, M., Hinchliffe, P., Wood, J., Harding, L. and Laws, A. (2003) ‘Novel mechanism of inhibiting b-lactamases by sulfonylation using b-sultams Bioorganic & Medicinal Chemistry Letters , 13 (24), pp. 4489-4492. ISSN 0960-894X

Page, M (2003) ‘Acyl vs sulfonyl transfer in N-acyl ?-sultams and 3-oxo-?-sultams Organic Letters , 6 (2), pp. 201-203. ISSN 1523-7060

Page, M (2003) ‘Past times - the efficiency of enzyme catalysisBiochemist , 25 (4), pp. 52-53. ISSN 0954-982X

Hinchliffe, P., Wood, J., Davis, A., Austin, R., Beckett, R. and Page, M. (2003) ‘Structure-activity relationships in the inactivation of elastase by ?-sultam Organic and Biomolecular Chemistry , 1 (1), pp. 67-80. ISSN 1477-0539

2002

Wood, J. and Page, M. (2002) ‘The mechanisms of sulfonyl transfer in strained cyclic sulfonamides Trends in Heterocyclic Chemistry , 8, pp. 19-34. ISSN 0972-432X

Page, M (2002) ‘Understanding metallo ?-lactamases American Society for Microbiology News , 68 (5), pp. 217-221.

Wood, J., Hinchliffe, P., Laws, A. and Page, M. (2002) ‘Reactivity and the mechanism of reactions of ?-sultams with NucleophilesJournal of the Chemical Society Perkins Transactions 2 , pp. 938-946. ISSN 1364-5471

Sykes, N., Macdonald, S. and Page, M. (2002) ‘Acylating agents as enzyme inhibitors and understanding their reactivity for drug design Journal of Medicinal Chemistry , 45 (13), pp. 2850-2856. ISSN 0022-2623

Wood, J., Hinchliffe, P., Davis, A., Austin, R. and Page, M. (2002) ‘Hydrolysis of a sulfonamide by a novel elimination mechanism generated by carbanion formation in the leaving group Chemical Communications , pp. 772-773. ISSN 1364-548X

Hadfield, P., Casey, L., Galt, R., Vilanova, B. and Page, M. (2002) ‘Imide and isatin derivatives as ?-lactam mimics of ?-lactam antibiotics ARKIVOC , vi, pp. 125-144. ISSN 1424-6376

Seny, D., Prosperi-Meys, C., Bebrone, C., Rossolini, G., Page, M., Noel, P., Frere, J. and Galleni, M. (2002) ‘Mutational analysis of the two zinc binding sites of the Bacillus cereus 569/H/9 metallo-?-lactamase Biochemical Journal , 363, pp. 687-696. ISSN 0264-6021

2001

Beardsell, M., Hinchliffe, P., Wood, J., Wilmouth, R., Schofield, C. and Page, M. (2001) ‘ ?-sultams - a novel class of serine protease inhibitors Chemical Communications , pp. 497-498. ISSN 1364-548X

Bounaga, S., Galleni, M., Laws, A. and Page, M. (2001) ‘Cysteinyl peptide Inhibitors of Bacillus cereus Zinc ?-LactamaseBioorganic & Medicinal Chemistry Letters , 9 (2), pp. 503-507. ISSN 0960-894X

Hinchliffe, P., Wood, J., Davis, A., Austin, R., Beckett, P. and Page, M. (2001) ‘Unusual steric effects in sulfonyl transfer reactions Perkin Transactions 2 , pp. 1503-1505. ISSN 1472-779X

Slater, M., Laws, A. and Page, M. (2001) ‘The relative catalytic efficiency of ?-lactamase catalysed acyl and phosphyl transfer Bioorganic Chemistry , 29, pp. 77-95. ISSN 0045-2068

2000

Allin, S., Vaidya, D., Page, M. and Slawin, A. (2000) ‘Highly diastereoselective synthesis of 2,3-dihydro-9bH- thiazolo[2,3-a]isoindolin-5-ones (00-2016CP) A R K I V O C , 2000, pp. 151-157. ISSN 1551-7004

Breytenbach, J., van Dyk, S., van den Heever, I., Allin, S., Hodkinson, C., Northfield, C. and Page, M. (2000) ‘Synthesis and antimicrobial activity of some isoindolin-1-ones derivativesBioorganic & Medicinal Chemistry Letters , 10 (15), pp. 1629-1635. ISSN 0960894X

Baxter, N., Rigoreau, L., Laws, A. and Page, M. (2000) ‘Reactivity and Mechanism in the Hydrolysis of ?-SultamsJournal of the American Chemical Society , 122 (14), pp. 3375-3380. ISSN 1520-5126

Llinás, A., Donoso, J., Vilanova, B., Frau, J., Munoz, F. and Page, M. (2000) ‘Thiol-catalysed hydrolysis of benzylpenicillinJournal of the Chemical Society Perkin Transactions 2 (7), pp. 1521-1525. ISSN 1472779X

Page, M. and Laws, A. (2000) ‘The Chemical Reactivity of ?-Lactams, ?-Sultams and ?-PhospholactamsTetrahedron , 56 (31), pp. 5631-5637. ISSN 0040-4020

Allin, S., Northfield, C., Page, M. and Slawin, A. (2000) ‘Approaches to the synthesis of non-racemic 3-substituted isoindolinone derivativesJournal of the Chemical Society Perkin Transactions 1 (11), pp. 1715-1721. ISSN 14727781

Allin, S., Vaidya, D., Page, M., Slawin, A. and Smith, T. (2000) ‘Highly diastereoselective synthesis and template manipulation of the thiazolo[2,3-a]isoindolin-1-one ring systemTetrahedron Letters , 41 (13), pp. 2219-2222. ISSN 0040-4039

1999

Page, M (1999) ‘The Reactivity of b-Lactams, the Mechanism of Catalysis and the Inhibition of b-LactamasesCurrent Pharmaceutical Design , 5 (11), pp. 895-913. ISSN 1381-6128

Rhazi, N., Page, M. and Frere, J. (1999) ‘Peptidase activity of b-lactamases Biochemical Journal , 341 (2), pp. 409-413. ISSN 0264-6021

Baxter, N., Laws, A., Rigoreau, L. and Page, M. (1999) ‘General acid catalysed hydrolysis of ?-sultams involves nucleophilic catalysisChemical Communications (23), pp. 2401-2402. ISSN 1359-7345

Barker, C., Page, M., Korn, S. and Monteith, M. (1999) ‘Esterase catalysed enantioselective ring closureChemical Communications (8), pp. 721-722. ISSN 1359-7345

Allin, S., Northfield, C., Page, M. and Slawin, A. (1999) ‘A new approach to the synthesis of non-racemic isoindolin-1-one derivativesTetrahedron Letters , 40 (1), pp. 141-142. ISSN 0040-4039

Allin, S., Northfield, C., Page, M. and Slawin, A. (1999) ‘A highly diastereoselective synthesis of 3-substituted isoindolin-1-one dericativesTetrahedron Letters , 40 (1), pp. 143-146. ISSN 0040-4039

1998

Llinas, A., Vilanova, B., Frau, J., Munoz, F., Donoso, J. and Page, M. (1998) ‘Chemical Reactivity of Penicillins and Cephalosporins. Intramolecular Involvement of the Acyl-Amido Side ChainThe Journal of Organic Chemistry , 63 (24), pp. 9052-9060. ISSN 0022-3263

Beard, T. and Page, M. (1998) ‘Enantioselective biotransformations using rhodococci Antonie van Leeuwenhoek , 74 (1/3), pp. 99-106. ISSN 0003-6072

Allin, S., Northfield, C., Page, M. and Slawin, A. (1998) ‘A facile and highly stereoselective approach to a polycyclic isoindolinone ring system via an N-acyliminium ion cyclization reactionTetrahedron Letters , 39 (27), pp. 4905-4908. ISSN 0040-4039

Page, M. and Laws, A. (1998) ‘The mechanism of catalysis and the inhibition of ?-lactamasesChemical Communications (16), pp. 1609-1617. ISSN 1359-7345

Bounaga, S., Laws, A., Galleni, M. and Page, M. (1998) ‘The mechanism of catalysis and the inhibition of the Bacillus cereus zinc-dependent b-lactamase Biochemical Journal , 331 (3), pp. 703-711. ISSN 0264-6021

Heathcote, D., Atherton, J., De Boos, G. and Page, M. (1998) ‘Kinetics of ionisation of 3-phenylcoumaran-2-one and reprotonation of the resulting carbanionJournal of the Chemical Society, Perkin Transactions 2 (3), pp. 541-546. ISSN 1472-779X

Heathcote, D., De Boos, G., Atherton, J. and Page, M. (1998) ‘Mechanism of hydrolysis of coumaran-2-onesJournal of the Chemical Society, Perkin Transactions 2 (3), pp. 535-540. ISSN 1472-779X

1997

Baxter, N. and Page, M. (1997) ‘Evidence for a trigonal bipyramidal intermediate during nucleophilic substitution at a sulfonyl centre and for a sulfonylium cation in the acid catalysed reactionChemical Communications (21), pp. 2037-2038. ISSN 1359-7345

Allin, S., Northfield, C., Page, M. and Slawin, A. (1997) ‘A highly diastereoselective synthesis of tricyclic lactams and their application as novel N-acyl iminium ion precursors in the synthesis of isoindolinone derivativesTetrahedron Letters , 38 (20), pp. 3627-3630. ISSN 0040-4039

Hadfield, P., Galt, R., Sawyer, Y., Layland, N. and Page, M. (1997) ‘An unexpected Mitsunobu reaction. A direct route to the 2,5-diazabicyclo[2.2.1]heptan-3-one skeleton as a ?-lactam mimic of ?-lactam antibioticsJournal of the Chemical Society, Perkin Transactions 1 (4), pp. 503-509. ISSN 1472-7781

1996

Baxter, N., Laws, A., Rigoreau, L. and Page, M. (1996) ‘The hydrolytic reactivity of B-sultamsJournal of the Chemical Society, Perkin Transactions 2 (11), p. 2245. ISSN 1472-779X

Laws, A. and Page, M. (1996) ‘The chemistry and structure-activity relationships of C3-quaternary ammonium cephem antibioticsJournal of Chemotherapy , 8, pp. 7-22. ISSN 1120-009X

1995

Page, M., Vilanova, B. and Layland, N. (1995) ‘pH Dependence of and kinetic solvent isotope effects on the methanolysis and hydrolysis of .beta.-lactams catalyzed by class C .beta.-lactamaseJournal of the American Chemical Society , 117 (49), pp. 12092-12095. ISSN 0002-7863

Layland, N., Laws, A., Vilanova, B. and Page, M. (1995) ‘Penicillin 3-aldehyde is a good substrate and not an inhibitor of ?-lactamases A and CJournal of the Chemical Society, Perkin Transactions 2 (5), pp. 869-870. ISSN 1472-779X

Page, M., Laws, A., Slater, M. and Stone, J. (1995) ‘Reactivity of ?-lactams and phosphonamidates and reactions with ?-lactamasePure and Applied Chemistry , 67 (5), pp. 711-717. ISSN 0033-4545

1994

Barton, P., Laws, A. and Page, M. (1994) ‘Structure-activity relationships in the esterase-catalysed hydrolysis and transesterification of esters and lactonesJournal of the Chemical Society, Perkin Transactions 2 (9), pp. 2021-2029. ISSN 1472-779X

Laws, A., Stone, J. and Page, M. (1994) ‘Large rate enhancement for the hydrolysis of a four-membered ring phosphonamidateChemical Communications (10), pp. 1223-1224. ISSN 1359-7345

1993

Barton, P. and Page, M. (1993) ‘The esterase catalysed resolution of lactones and spirodilactoneJournal of the Chemical Society, Perkin Transactions 2 (12), pp. 2317-2318. ISSN 1472-779X

Laws, A., Page, M. and Slater, M. (1993) ‘The mechanism of reactions catalysed by the serine ?-lactamasesBioorganic & Medicinal Chemistry Letters , 3 (11), pp. 2317-2322. ISSN 0960-894X

Page, M (1993) ‘Reactions of Aldehydes and Ketones and their Derivatives’. In: Organic Reaction Mechanisms. : John Wiley & Sons. pp. 1-16. ISBN 9780471953371

Laws, A., Layland, N., Proctor, D. and Page, M. (1993) ‘The roles of the carboxy group in ?-lactam antibiotics and lysine 234 in ?-lactamase IJournal of the Chemical Society, Perkin Transactions 2 (1), pp. 17-21. ISSN 1472-779X

Casey, L., Galt, R. and Page, M. (1993) ‘The mechanisms of hydrolysis of the ?-lactam isatin and its derivativesJournal of the Chemical Society, Perkin Transactions 2 (1), pp. 23-28. ISSN 1472-779X

1992

Barton, P. and Page, M. (1992) ‘The resolution of racemic 1,2-diols by the esterase catalysed hydrolysis of the corresponding cyclic carbonateTetrahedron , 48 (36), pp. 7731-7734. ISSN 0040-4020

Page, M (1992) ‘Reactions of Aldehydes and Ketones and their Derivatives’. In: Organic Reaction Mechanisms. : John Wiley & Sons. pp. 1-15. ISBN 9780471942245

Page, M (1992) ‘The mechanisms of reactions of(beta)lactams’. In: The chemistry of Beta lactams. London: Blackie Academic and Professional. pp. 129-147. ISBN 9780751400618

Page, M (1992) ‘Structure-activity relationships : chemical’. In: The chemistry of (beta) lactams. London: Blackie Academic and Professional. pp. 79-100. ISBN 9780751400618

1991

Davis, A., Proctor, P. and Page, M. (1991) ‘Alcohol-catalysed hydrolysis of benzylpenicillinJournal of the Chemical Society, Perkin Transactions 2 (8), pp. 1213-1217. ISSN 1472-779X

Davis, A., Layland, N., Page, M., Martin, F. and O'Ferrall, R. (1991) ‘Thiazolidine ring opening in penicillin derivatives. Part 2. Enamine formationJournal of the Chemical Society, Perkin Transactions 2 (8), pp. 1225-1229. ISSN 1472-779X

Davis, A., Jones, M. and Page, M. (1991) ‘Thiazolidine ring opening in penicillin derivatives. Part 1. Imine formationJournal of the Chemical Society, Perkin Transactions 2 (8), pp. 1219-1223. ISSN 1472-779X

Page, M (1991) ‘Reactions of Aldehydes and Ketones and their Derivatives’. In: Organic Reaction Mechanisms. : John Wiley & Sons. pp. 1-20. ISBN 9780471937944

Page, M (1991) ‘The Energetics of Intramolecular Reactions and Enzyme CatalysisPhilosophical Transactions of the Royal Society B: Biological Sciences , 332 (1263), pp. 149-156. ISSN 0962-8436

Jones, M. and Page, M. (1991) ‘An esterase with ?-lactamase activityChemical Communications (5), pp. 316-317. ISSN 1359-7345

1990

Davies, K. and Page, M. (1990) ‘Reaction rates and thermodynamic equilibration of tetrahedral intermediates: the alcoholysis of cephalosporinsChemical Communications (20), pp. 1448-1450. ISSN 1359-7345

Page, M (1990) ‘Reactions of Aldehydes and Ketones and their Derivatives’. In: Organic Reaction Mechanisms. : John Wiley & Sons. pp. 1-18. ISBN 9780471931034

Page, M., Webster, P. and Ghosez, L. (1990) ‘The hydrolysis of azetidinyl amidinium salts. Part 2. Substituent effects, buffer catalysis, and the reaction mechanismJournal of the Chemical Society, Perkin Transactions 2 (5), pp. 813-823. ISSN 1472-779X

Page, M., Webster, P. and Ghosez, L. (1990) ‘The hydrolysis of azetidinyl amidinium salts. Part 1. The unimportance of strain release in the four-membered ringJournal of the Chemical Society, Perkin Transactions 2 (5), pp. 805-811. ISSN 1472-779X

Page, M. and Laws, A. (1990) ‘Molecular recognition in beta lactamases’. In: Molecular mechanisms in bioorganic processes. : Royal Society of Chemistry. pp. 319-330. ISBN 9780851869469

1989

Laws, A. and Page, M. (1989) ‘The effect of the carboxy group on the chemical and ?-lactamase reactivity of ?-lactam antibioticsJournal of the Chemical Society, Perkin Transactions 2 (10), pp. 1577-1581. ISSN 1472-779X

Page, M (1989) ‘Reactions of Aldehydes and Ketones and their Derivatives’. In: Organic Reaction Mechanisms. : John Wiley & Sons. pp. 1-20. ISBN 9780471928256

Jones, M., Buckwell, S., Page, M. and Wrigglesworth, R. (1989) ‘A reversible inhibitor of ?-lactamase I from Bacillus cereus Chemical Communications (2), pp. 70-71. ISSN 1359-7345

1988

Buckwell, S., Page, M., Longridge, J. and Waley, S. (1988) ‘Hydrolysis of 3-substituted cephalosporins catalysed by ?-lactamases I and II from Bacillus cereus and by hydroxide ionJournal of the Chemical Society, Perkin Transactions 2 (10), pp. 1823-1827. ISSN 1472-779X

Buckwell, S., Page, M. and Longridge, J. (1988) ‘Hydrolysis of 6-alkyl penicillins catalysed by ?-lactamase I from Bacillus cereus and by hydroxide ionJournal of the Chemical Society, Perkin Transactions 2 (10), pp. 1809-1813. ISSN 1472-779X

Buckwell, S., Page, M., Waley, S. and Longridge, J. (1988) ‘Hydrolysis of 7-substituted cephalosporins catalysed by ?-lactamases I and II from Bacillus cereus and by hydroxide ionJournal of the Chemical Society, Perkin Transactions 2 (10), pp. 1815-1821. ISSN 1472-779X

Page, M (1988) ‘Reactions of Aldehydes and Ketones and their Derivatives’. In: Organic Reaction Mechanisms. : John Wiley & Sons. pp. 1-22. ISBN 9780471920298

Page, M (1988) ‘Energy differences and their relevance to enzyme and intramolecular catalysisJournal of Molecular Catalysis A: Chemical , 47, pp. 241-253. ISSN 1381-1169

Page, M., Webster, P., Ghosez, L. and Bogden, S. (1988) ‘The ease of C-N bond fission in azetidine derivativesActualite Chimique, L' , pp. 272-276. ISSN 0151-9093

1987

Page, M (1987) ‘The Mechanisms of Reactions of ?-Lactam Antibiotics’. In: Advances in Physical Organic Chemistry Volume 23. : Academic Press. pp. 165-270. ISBN 9780120335237

Sheldrick, B., Akrigg, D., Page, M. and Cox, G. (1987) ‘Structures of carbocyclic analogues of penicillin. 3. N-(Bicyclo[3.2.0]hept-2-ene-6-spiro-2'-dioxolane-7-yl)phthalimideActa Crystallographica Section C Crystal Structure Communications , 43 (3), pp. 595-597. ISSN 0108-2701

Page, M (1987) ‘Reactions of Aldehydes and Ketones and their Derivatives’. In: Organic Reaction Mechanisms. : John Wiley & Sons. pp. 1-27. ISBN 9780471920786

Sheldrick, B., Akrigg, D., Page, M. and Cox, G. (1987) ‘Structures of carbocyclic analogues of penicillin. 2. N-(3,4-Dihydroxy-7-oxobicyclo[3.2.0]hept-6-yl)succinimideActa Crystallographica Section C Crystal Structure Communications , 43 (3), pp. 594-595. ISSN 0108-2701

Page, M (1987) ‘Reactions of Aldehydes and Ketones and their Derivatives’. In: Organic Reaction Mechanisms. : John Wiley & Sons. pp. 1-27. ISBN 9780471920786

Page, M., Webster, P., Bogdan, S., Tremerie, B. and Ghosez, L. (1987) ‘Ease of C-N bond cleavage in four-membered ringsChemical Communications (5), pp. 318-319. ISSN 1359-7345

1986

Buckwell, S., Page, M. and Longridge, J. (1986) ‘Equilibria between enamine and B-unsaturated imine in cephalosporin hydrolysisChemical Communications (13), pp. 1039-1040. ISSN 1359-7345

Agathocleous, D., Cox, G. and Page, M. (1986) ‘Stereochemistry and ring opening of a carbocyclic analogue of a 1-oxapenamTetrahedron Letters , 27 (14), pp. 1631-1634. ISSN 0040-4039

Page, M., Render, D. and Bernath, G. (1986) ‘Stereochemical studies. Part 112. Geometrical dependence of intramolecular catalysis in the hydrolysis and aminolysis of aryl estersJournal of the Chemical Society, Perkin Transactions 2 (6), pp. 867-871. ISSN 1472-779X

Page, M (1986) ‘Reactions of Aldehydes and Ketones and their Derivatives’. In: Organic Reaction Mechanisms. : John Wiley & Sons. pp. 1-27. ISBN 9780471917298

1985

Sheldrick, B., Akrigg, D., Page, M. and Agathocleous, D. (1985) ‘Structure of a carbocyclic oxapenam analogueActa Crystallographica Section C Crystal Structure Communications , 41 (12), pp. 1816-1817. ISSN 0108-2701

Davis, A. and Page, M. (1985) ‘Opening of the thiazolidine ring of penicillin derivativesChemical Communications (23), pp. 1702-1704. ISSN 1359-7345

Sheldrick, B., Akrigg, D., Page, M. and Agathocleous, D. (1985) ‘Structure of a carbocyclic analogue of penicillinActa Crystallographica Section C Crystal Structure Communications , 41 (6), pp. 942-944. ISSN 0108-2701

1984

Davis, A., Page, M., Mason, S. and Watt, I. (1984) ‘The effective concentration of a hydride transfer reactionChemical Communications (24), pp. 1671-1672. ISSN 1359-7345

Sheldrick, B., Akrigg, D., Page, M. and Agathocleous, D. (1984) ‘N-{(1R*,5S*,7R*)-6-Oxobicyclo[3.2.0]hept-2-en-7-yl}phthalimide, C15H11NO3Acta Crystallographica Section C Crystal Structure Communications , 40 (7), pp. 1217-1219. ISSN 0108-2701

Page, M (1984) ‘Chapter 7 The mechanisms of chemical catalysis used by enzymes’. In: New Comprehensive Biochemistry. : Elsevier BV. pp. 229-269. ISBN 9780444805041

Page, M (1984) ‘Chapter 1 The energetics and specificity of enzyme—substrate interactions’. In: New Comprehensive Biochemistry. : Elsevier BV. pp. 1-54. ISBN 9780444805041

Page, M (1984) ‘Reactions of Aldehydes and Ketones and their Derivatives’. In: Organic Reaction Mechanisms. : John Wiley & Sons. pp. 1-32. ISBN 9780471907978

Page, M. and Crombie, D. (1984) ‘Reactions in macromolecular systems’. In: Macromolecular Chemistry. : Royal Society of Chemistry. pp. 351-374. ISBN 9780-851868769

Page, M. and Proctor, P. (1984) ‘Mechanism of .beta.-lactam ring opening in cephalosporinsJournal of the American Chemical Society , 106 (13), pp. 3820-3825. ISSN 0002-7863

Page, M (1984) ‘The mechanisms of reactions of .beta.-lactam antibioticsAccounts of Chemical Research , 17 (4), pp. 144-151. ISSN 0001-4842

1983

Page, M (1983) ‘Reactions of Aldehydes and Ketones and their Derivatives’. In: Organic Reaction Mechanisms. : John Wiley & Sons. pp. 1-32. ISBN 9780471905035

1982

Proctor, P., Gensmantel, N. and Page, M. (1982) ‘The chemical reactivity of penicillins and other b-lactam antibioticsJournal of the Chemical Society, Perkin Transactions 2 (9), pp. 1185-1192. ISSN 1472-779X

Crombie, D. and Page, M. (1982) ‘Reactions in macromolecular systems’. In: Macromolecular Chemistry. : Royal Society of Chemistry. pp. 322-346. ISBN 9780851868660

Page, M (1982) ‘Reactions of Aldehydes and Ketones and Their Derivatives’. In: Organic Reaction Mechanisms. : John Wiley & Sons. pp. 1-17. ISBN 9780471902027

Gensmantel, N. and Page, M. (1982) ‘The micelle-catalysed hydrolysis of benzylpenicillinJournal of the Chemical Society, Perkin Transactions 2 (2), pp. 147-153. ISSN 1472-779X

Gensmantel, N. and Page, M. (1982) ‘The effect of increasing the hydrophobicity of penicillin on its micelle-catalysed hydrolysisJournal of the Chemical Society, Perkin Transactions 2 (2), pp. 155-159. ISSN 1472-779X

1981

Page, M (1981) ‘Reactions of Aldehydes and Ketones and Their Derivatives’. In: Organic Reaction Mechanisms. : John Wiley & Sons. pp. 1-21. ISBN 9780471104599

1980

Gosney, A. and Page, M. (1980) ‘The mechanism of nitrosation of 4-nitrophenol with aqueous nitrous acidJournal of the Chemical Society, Perkin Transactions 2 (12), pp. 1783-1787. ISSN 1472-779X

Gensmantel, N., Proctor, P. and Page, M. (1980) ‘Metal-ion catalysed hydrolysis of some ?-lactam antibioticsJournal of the Chemical Society, Perkin Transactions 2 (11), pp. 1725-1732. ISSN 1472-779X

Page, M (1980) ‘Transition states, standard states and enzymic catalysisInternational Journal of Biochemistry , 11 (5), pp. 331-335. ISSN 1357-2725

Morris, J. and Page, M. (1980) ‘Intramolecular nucleophilic and general acid catalysis in the hydrolysis of an amide. Some comments on the mechanism of catalysis by serine proteasesJournal of the Chemical Society, Perkin Transactions 2 (7), pp. 1131-1136. ISSN 1472-779X

Morris, J. and Page, M. (1980) ‘Hydroxy-group participation in the hydrolysis of amides and its effective concentration in the absence of strain effectsJournal of the Chemical Society, Perkin Transactions 2 (4), pp. 679-684. ISSN 1472-779X

Morris, J. and Page, M. (1980) ‘Structure-reactivity relationships and the mechanism of general base catalysis in the hydrolysis of a hydroxy-amide. Concerted breakdown of a tetrahedral intermediateJournal of the Chemical Society, Perkin Transactions 2 (4), pp. 685-692. ISSN 1472-779X

Morris, J. and Page, M. (1980) ‘Intra- and inter-molecular catalysis in the aminolysis of benzylpenicillinJournal of the Chemical Society, Perkin Transactions 2 (1), pp. 212-219. ISSN 1472-779X

Morris, J. and Page, M. (1980) ‘Buffer catalysis in the hydrazinolysis of benzylpenicillinJournal of the Chemical Society, Perkin Transactions 2 (1), pp. 220-224. ISSN 1472-779X

1979

Page, M (1979) ‘The principles of enzymatic catalysisInternational Journal of Biochemistry , 10 (6), pp. 471-476. ISSN 1357-2725

Martin, A., Morris, J. and Page, M. (1979) ‘Intramolecular general acid catalysis in the aminolysis of benzylpenicillin. A preferred direction of nucleophilic attackChemical Communications (6), pp. 298-299. ISSN 1359-7345

Gensmantel, N. and Page, M. (1979) ‘The aminolysis of penicillin derivatives. Rate constants for the formation and breakdown of the tetrahedral addition intermediateJournal of the Chemical Society, Perkin Transactions 2 (2), pp. 137-142. ISSN 1472-779X

1978

Morris, J. and Page, M. (1978) ‘Intramolecular nucleophilic and general acid catalysis in the hydrolysis of an amideChemical Communications (14), pp. 591-591. ISSN 1359-7345

Gensmantel, N. and Page, M. (1978) ‘A tetrahedral intermediate in the aminolysis of benzylpenicillinChemical Communications (9), pp. 374-375. ISSN 1359-7345

Gensmantel, N., Gowling, E. and Page, M. (1978) ‘Metal ion catalysis in the aminolysis of penicillinJournal of the Chemical Society, Perkin Transactions 2 (4), pp. 335-342. ISSN 1472-779X

1977

Page, M (1977) ‘Entropy, Binding Energy, and Enzymic CatalysisAngewandte Chemie International Edition , 16 (7), pp. 449-459. ISSN 1433-7851

1976

Page, M (1976) ‘Binding energy and enzymic catalysisBiochemical and Biophysical Research Communications , 72 (2), pp. 456-461. ISSN 0006-291X

Martin, A., Morris, J. and Page, M. (1976) ‘Intra-and inter-molecular general base catalysis in the aminolysis of benzylpenicillinChemical Communications (13), pp. 495-496. ISSN 1359-7345

1975

Page, M (1975) ‘Reactions of Acids and their Derivatives’. In: Organic Reaction Mechanisms. : John Wiley & Sons. pp. 23-79. ISBN 9780471018643

1974

Page, M (1974) ‘Reactions of Acids and their Derivatives’. In: Organic Reaction Mechanisms. : John Wiley & Sons. pp. 23-67. ISBN 9780471126935

Jencks, W. and Page, M. (1974) ‘Orbital steering, entropy, and rate accelerationsBiochemical and Biophysical Research Communications , 57 (3), pp. 887-892. ISSN 0006-291X

Bell, R., Critchlow, J. and Page, M. (1974) ‘Ground state and transition state effects in the acylation of a-chymotrypsin in organic solvent-water mixturesJournal of the Chemical Society, Perkin Transactions 2 (1), pp. 66-70. ISSN 1472-779X

1973

Bell, R. and Page, M. (1973) ‘Intramolecular general acid catalysis in the halogenation of ketonesJournal of the Chemical Society, Perkin Transactions 2 (12), pp. 1681-1686. ISSN 1472-779X

Page, M (1973) ‘The energetics of neighbouring group participationChemical Society Review , 2 (3), pp. 295-323. ISSN 0306-0012

Page, M (1973) ‘Reactions of Acids and Their Derivatives’. In: Organic Reaction Mechanisms. : John Wiley & Sons. pp. 21-60. ISBN 9780471126904

1972

Page, M. and Jencks, W. (1972) ‘General base and acid catalysis in the hydrazinolysis of acetylimidazoleJournal of the American Chemical Society , 94 (25), pp. 8828-8838. ISSN 0002-7863

Page, M. and Jencks, W. (1972) ‘Intramolecular general base catalysis in the aminolysis of acetylimidazole and methyl formate by diaminesJournal of the American Chemical Society , 94 (25), pp. 8818-8827. ISSN 0002-7863

Page, M (1972) ‘Entropic rate accelerations and orbital steeringBiochemical and Biophysical Research Communications , 49 (4), pp. 940-944. ISSN 0006-291X

Capon, B. and Page, M. (1972) ‘Intramolecular nucleophilic assistance in the reactions of O,O'-benzylidene catecholsJournal of the Chemical Society, Perkin Transactions 2 (14), pp. 2057-2062. ISSN 1472-779X

Fox, J., Page, M., Satterthwait, A. and Jencks, W. (1972) ‘Nonlinear broensted relation for general acid-base catalysis of aminolysis reactionsJournal of the American Chemical Society , 94 (13), pp. 4729-4732. ISSN 0002-7863

Capon, B., Page, M. and Sankey, G. (1972) ‘The kinetics and mechanism of the hydrolysis of 2,3-(phenylmethylenedioxy)benzoic acid (OO?-benzylidene-2,3-dihydroxybenzoic acid)Journal of the Chemical Society, Perkin Transactions 2 (5), pp. 529-532. ISSN 1472-779X

Capon, B. and Page, M. (1972) ‘The kinetics and mechanism of the hydrolysis of 2,3-(phenylmethylenedioxy)benzene (Oo'-benzylidenecatechol) and benzaldehyde diphenyl acetalJournal of the Chemical Society, Perkin Transactions 2 (5), pp. 522-529. ISSN 1472-779X

Page, M. and Jencks, W. (1972) ‘Uncatalyzed aminolysis of acetylimidazole. Limiting product-like transition state for acyl transferJournal of the American Chemical Society , 94 (9), pp. 3263-3264. ISSN 0002-7863

1971

Page, M. and Jencks, W. (1971) ‘Entropic Contributions to Rate Accelerations in Enzymic and Intramolecular Reactions and the Chelate EffectNational Academy of Sciences. Proceedings , 68 (8), pp. 1678-1683. ISSN 0027-8424

Capon, B. and Page, M. (1971) ‘The kinetics and mechanism of the hydrolysis of esters of cis- and trans-2-hydroxycyclopentanecarboxylic acid and 3-hydroxybutyric acidJournal of the Chemical Society B, physical organic , pp. 741-744. ISSN 1472-779X

1970

Capon, B. and Page, M. (1970) ‘The mechanism of hydrolysis of 2,3-OO-benzylidene-norbornane-exo-2,-exo-3-diolsJournal of the Chemical Society D: Chemical Communications (21), pp. 1443-1444. ISSN 0577-6171

Research Degree Supervision

Areas of research supervision include:

  • Drug design - inhibitors of enzymes of interest to disease states.
  • The chemistry of β-lactam antibiotics and their derivatives. Overcoming bacterial resistance to antibiotics, particularly β-lactam antibiotics.
  • The mechanism of action of enzymes, particularly β-lactamases, esterases, proteases, lipases and nitrilases.
  • The use of enzymes in synthesis - enantioselective biotransformations.
  • Metal-ion catalysed reactions, mechanism and design of synthetically useful catalysts.
  • Mechanisms and kinetics of organic reactions
  • Mechanisms and kinetics of organic reactions in liquid ammonia
Last updated Thursday 6 March 2014
Thank you for your feedback.

Your feedback has been sent to the University Web/E-Marketing Team.



Excellent
Good
Satisfactory
Needs improvement

Excellent
Good
Satisfactory
Needs improvement

Excellent
Good
Satisfactory
Needs improvement

VAT registration number 516 3101 90

All rights reserved ©