Professor Michael Pagem.i.page@hud.ac.uk | 01484 472534
Mike Page studied Chemistry at the now University of Brighton in 1967 and completed his PhD at the universities of Leicester and Glasgow in 1970. He worked as a postdoctoral research fellow with Professor W P Jencks in the United States between 1970 and 1972 and then with Professor R P Bell in 1972-1973. He was then appointed Lecturer at the now University of Huddersfield where he has been Senior Lecturer, Principal Lecturer, Reader and then Professor in 1985. Mike was Head of the Department of Chemical and Biological Sciences from 1985 until 1997 and Dean of the School of Applied Sciences from 1989 to 2003. He also acted as Dean of Research from 1987-2003. He went on to become the University’s Deputy Vice-Chancellor with responsibility for planning, resources and research, from which he retired in 2009. He was awarded the honorary emeritus professorship by the University the following year and became the first recipient of a new award, Doctor of the University to add to his existing two DSc awards. Since then, Mike has remained an active researcher and is Director of the research unit IPOS. He was recently asked to take up the position of Acting Dean of the School of Applied Sciences as an interim appointment.
Mike Page has been a member of BBSRC and EPSRC committees, including BioMolecular Sciences, Molecular Recognition, chemistry and organic chemistry. He has represented the UK on international committees such as European Union committees and IUPAC. He was Chairman of the Committee of Heads of Polytechnic Chemistry Departments and a member of the CNAA Chemistry Board. He was Chairman of the Royal Society of Chemistry (RSC) Qualifications and Education Board and a member of the Council and a member of several other RSC committees. He is currently Chair of the RSC Disciplinary Committee and member of the Chemistry Biology Interface Division committee. He was a member of the HEFCE Research Assessment Exercise panel for Chemistry in 1992 and was a member of the HEFCE pilot teaching assessment of chemistry. He has been Chairman of the RSC Organic Reaction Mechanisms Group and a member of the Editorial Boards of Chemical Communications, JCS Perkin 2, Natural Products, Biochemical Journal and J. Phys. Org. Chem.
He was awarded the RSC Perkin Transactions 150th Anniversary Prize 1991; RSC Organic Reaction Mechanisms 2003 and SCI R&D for Society Award 2010. Mike Page has published over 200 research papers and supervised over 50 PhD students. He has edited books on The Chemistry of Enzyme Action (Elsevier 1984), Enzyme Mechanisms (Roy. Soc. Chem. 1987) and The Chemistry of β-Lactam Antibiotics (Blackie 1992). He recently co-authored, with Andrew Williams, a postgraduate book on Organic and BioOrganic Mechanisms (Longman 1997). Mike has given many international plenary lectures and contributed many papers at symposia world-wide.
Mike has worked closely with industry, particularly the pharmaceutical sector and has had colloborative research projects with AstraZeneca, GlaxoSmithKline, Avecia, Syngenta, James Robinson, British Biotech, ICI Pharm., Fisons, PanTherix, Proteus and NPilPharma.
His main areas of research interest are:
These areas of research are inter-related by the theme of the mechanisms of reactions.
Ji, P., Atherton, J. and Page, M. (2012) ‘Copper catalysed azide–alkyne cycloaddition (CuAAC) in liquid ammonia’ Organic & Biomolecular Chemistry , 10 (39), pp. 7965-7969. ISSN 1477-0520
Ji, P., Atherton, J. and Page, M. (2012) ‘Copper(I)-Catalyzed Amination of Aryl Halides in Liquid Ammonia’ The Journal of Organic Chemistry , 77 (17), pp. 7471-7478. ISSN 0022-3263
Fink, A. and Page, M. (2012) ‘The mechanisms of catalysis by ?-lactamases ’. In: ?-Lactamases. New York, USA: Nova Science. pp. 161-198. ISBN 978-1-61324-638-2
Powles, N., Atherton, J. and Page, M. (2012) ‘Reactive intermediates in the H-phosphonate synthesis of oligonucleotides’ Organic and Biomolecular Chemistry , 10 (30), pp. 5940-5947. ISSN 1477-0539
Ji, P., Atherton, J. and Page, M. (2012) ‘Organic reactivity in liquid ammonia’ Organic & Biomolecular Chemistry , 10 (30), pp. 5732-5739. ISSN 1477-0520
Ji, P., Powles, N., Atherton, J. and Page, M. (2011) ‘Ionization of Carbon Acids in Liquid Ammonia’ Organic Letters , 13 (22), pp. 6118-6121. ISSN 1523-7060
Ji, P., Atherton, J. and Page, M. (2011) ‘The Kinetics and Mechanisms of Aromatic Nucleophilic Substitution Reactions in Liquid Ammonia’ The Journal of Organic Chemistry , 76 (9), pp. 3286-3295. ISSN 00223263
Ward, R., Lallemand, F., de Witte, P., Crichton, R., Piette, J., Tipton, K., Hemmings, K., Pitard, A., Page, M. and Corte, L. (2011) ‘Anti-inflammatory actions of a taurine analogue, ethane ?-sultam, in phagocytic cells, in vivo and in vitro’ Biochemical Pharmacology , 81 (6), pp. 743-751. ISSN 0006-2952
Ji, P., Atherton, J. and Page, M. (2011) ‘Liquid Ammonia as a Dipolar Aprotic Solvent for Aliphatic Nucleophilic Substitution Reactions’ The Journal of Organic Chemistry , 76 (5), pp. 1425-1435. ISSN 00223263
Ward, R., Lallemand, F., Taylor, D., Dexter, D., de Witte, P., Chrichton, R., Piette, J., Tipton, K., Hemming, K., Pitard, A., Page, M. and Corte, L. (2011) ‘Anti-inflammatory actions of a taurine analogue - ethane beta-sultam’ Biochemical Pharmacology , 81 (6), pp. 743-751. ISSN 0006-2952
Page, M (2010) ‘Structure and reactivity of ?-lactams’. In: Amino Acids, Peptides and Proteins in Organic Chemistry: Building Blocks, Catalysis and Coupling Chemistry . London, UK: Wiley. pp. 169-200. ISBN 978-3-527-32102-5
Ji, P., Atherton, J. and Page, M. (2010) ‘The kinetics and mechanisms of organic reactions in liquid ammonia’ Faraday Discussions , 145, pp. 15-25. ISSN 1359-6640
Russell, M., Laws, A., Atherton, J. and Page, M. (2009) ‘The kinetics and mechanism of the acid-catalysed detritylation of nucleotides in non-aqueous solution’ Organic and Biomolecular Chemistry , 7 (1), pp. 52-57. ISSN 1477-0539
Badarau, A. and Page, M. (2008) ‘Loss of enzyme activity during turnover of the Bacillus cereus ?-lactamase catalysed hydrolysis of ?-lactams due to loss of zinc ion’ JBIC Journal of Biological Inorganic Chemistry , 13 (6), pp. 919-928. ISSN 09498257
Russell, M., Laws, A., Atherton, J. and Page, M. (2008) ‘The mechanism of the phosphoramidite synthesis of polynucleotides’ Organic and Biomolecular Chemistry , 6 (18), pp. 3270-3275. ISSN 1477-0539
Tsang, W., Ahmed, N., Hemming, K. and Page, M. (2008) ‘An activated sulfonylating agent that undergoes general base-catalyzed hydrolysis by amines in preference to aminolysis’ The Journal of Organic Chemistry , 73 (12), pp. 4504-4512. ISSN 00223263
Mulchande, J., Guedes, R., Tsang, W., Page, M., Moreira, R. and Iley, J. (2008) ‘Azetidine-2,4-diones (4-Oxo-?-lactams) as Scaffolds for Designing Elastase Inhibitors’ Journal of Medicinal Chemistry , 51 (6), pp. 1783-1790. ISSN 0022-2623
Page, M. and Badarau, A. (2008) ‘The Mechanisms of Catalysis by Metallo ?-Lactamases’ Bioinorganic Chemistry and Applications , 2008, pp. 1-14. ISSN 1565-3633
Tsang, W., Ahmed, N., Hemming, K. and Page, M. (2007) ‘Reactivity and selectivity in the inhibition of elastase by 3-oxo-?-sultams and in their hydrolysis’ Organic and Biomolecular Chemistry , 5 (24), pp. 3993-4000. ISSN 1477-0539
Stirling, M., Blacker, J. and Page, M. (2007) ‘Chemoenzymatic dynamic kinetic resolution of secondary amines ’ Tetrahedron Letters , 48 (7), pp. 1247-1250. ISSN 0040-4039
Hanusek, J., Russell, M., Laws, A. and Page, M. (2007) ‘Evidence for the formation of isothiocyanate during sulphurisation of triphenyl phosphines using xanthane hydride ’ Tetrahedron Letters , 48 (3), pp. 417-419. ISSN 0040-4039
Tsang, W., Ahmed, N. and Page, M. (2007) ‘The aminolysis of N-Aroyl ?-Lactams occurs by a concerted mechanism ’ Organic and Biomolecular Chemistry , 5 (3), pp. 485-493. ISSN 1477-0539
Badarau, A., Damblon, C. and Page, M. (2007) ‘The activity of the dinuclear cobalt-?-lactamase from bacillus cereus in catalysing the hydrolysis of ?-lactams ’ Biochemical Journal , 401, pp. 197-203. ISSN 0264-6021
Hanusek, J., Russell, M., Laws, A., Jansa, P., Atherton, J., Fettes, K. and Page, M. (2007) ‘Mechanism of the sulphurisation of phosphines and phosphites using 3-amino-1,2,4-dithiazole-5-thione (Xanthane Hydride) ’ Organic and Biomolecular Chemistry , 5 (3), pp. 478-484. ISSN 1477-0539
Blacker, A., Stirling, M. and Page, M. (2007) ‘Catalytic racemisation of chiral amines and application in dynamic kinetic resolution’ Organic Process Research and Development , 11 (3), pp. 642-648. ISSN 1083-6160
Hemming, K., O'Gorman, P. and Page, M. (2006) ‘The synthesis of azabicyclo[4.2.1]nonenes by the addition of a cyclopropenone to 4-vinyl substituted 1-azetines-isomers of the homotropane nucleus’ Tetrahedron Letters , 47, pp. 425-428. ISSN 0040-4039
Badarau, A. and Page, M. (2006) ‘The variation of catalytic efficiency of bacillus cereus metallo- ?-lactamase with different active site metal ions ’ Biochemistry , 45 (35), pp. 10654-10666. ISSN 1520-4995
Badarau, A. and Page, M. (2006) ‘Enzyme deactivation due to metal-ion dissociation during turnover of the cobalt ?-lactamase catalysed hydrolysis of ?-lactams’ Biochemistry , 45 (35), pp. 11012-11020. ISSN 0006-2960
Page, M., Tsang, W. and Ahmed, N. (2006) ‘Comparison of the mechanisms of reactions of ?-Lactams and ?-Sultams including their reactions with some serine enzymes ’ Journal of Physical Organic Chemistry , 19 (8-9), pp. 446-451. ISSN 1099-1395
Tsang, W., Ahmed, N., Hemming, K. and Page, M. (2005) ‘Competitive endo- and exo-cyclic C-N fission in the hydrolysis of N-aroyl ?-lactams ’ Canadian Journal of Chemistry , 83 (9), pp. 1432-1439. ISSN 1480-3291
Llinas, A., Ahmed, N., Cordaro, M., Laws, A., Frere, J., Delmarcelle, M., Silvaggi, N., Kelly, J. and Page, M. (2005) ‘The inactivation of bacterial DD-peptidase by ?-sultams ’ Biochemistry , 44 (21), pp. 7738-7746. ISSN 1520-4995
Badarau, A., Llinas, A., Laws, A., Damblon, C. and Page, M. (2005) ‘Inhibitors of metallo-?-lactamase generated from ?-lactam antibiotics ’ Biochemistry , 44 (24), pp. 8578-8589. ISSN 1520-4995
Tsang, W., Ahmed, N., Harding, L., Hemming, K., Laws, A. and Page, M. (2005) ‘Acylation versus sulfonylation in the inhibition of elastase by 3-oxo-beta-sultams ’ Journal of the American Chemical Society , 127 (25), pp. 8946-8947. ISSN 1520-5126
Tsang, W., Ahmed, N., Hinchliffe, P., Wood, J., Harding, L., Laws, A. and Page, M. (2005) ‘Different transition-state structures for the reactions of ?-lactams and analogous ?-sultams with serine ?-lactamases ’ Journal of the American Chemical Society , 127 (49), pp. 17556-17564. ISSN 1520-5126
Llinas, A., Vilanova, B. and Page, M. (2004) ‘The thiol catalysed hydrolysis of cephalosporins and possible rate-limiting amine anion expulsion ’ Journal of Physical Organic Chemistry , 17 (6-7), pp. 521-528. ISSN 1099-1395
Tsang, W., Dhanda, A., Schofield, C., Frere, J., Galleni, M. and Page, M. (2004) ‘The inhibition of metallo-?-lactamase by thioxo-cephalosporin derivatives ’ Bioorganic & Medicinal Chemistry Letters , 14 (7), pp. 1737-1739. ISSN 0960-894X
Page, M (2004) ‘?-sultams-mechanism of reactions and use as inhibitors of serine proteases ’ Accounts of Chemical Research , 37 (5), pp. 297-303. ISSN 0001-4842
Llinas, A. and Page, M. (2004) ‘Intramolecular general acid catalysis in the aminolysis of ?-lactam antibiotics ’ Organic and Biomolecular Chemistry , 2, pp. 651-654. ISSN 1477-0539
Ahmed, N., Tsang, W. and Page, M. (2004) ‘Acyl vs Sulfonyl Transfer in N-Acyl ?-Sultams and 3-Oxo-? sultams ’ Organic Letters , 6 (2), pp. 201-203. ISSN 15237060
Tsang, W., Dhanda, A., Schofield, C. and Page, M. (2004) ‘Kinetics and mechanisms of hydrolysis and aminolysis of thioxocephalosporins’ The Journal of Organic Chemistry , 69 (2), pp. 339-344. ISSN 00223263
Page, M., Hinchliffe, P., Wood, J., Harding, L. and Laws, A. (2003) ‘Novel mechanism of inhibiting b-lactamases by sulfonylation using b-sultams ’ Bioorganic & Medicinal Chemistry Letters , 13 (24), pp. 4489-4492. ISSN 0960-894X
Page, M (2003) ‘Acyl vs sulfonyl transfer in N-acyl ?-sultams and 3-oxo-?-sultams ’ Organic Letters , 6 (2), pp. 201-203. ISSN 1523-7060
Page, M (2003) ‘Past times - the efficiency of enzyme catalysis’ Biochemist , 25 (4), pp. 52-53. ISSN 0954-982X
Hinchliffe, P., Wood, J., Davis, A., Austin, R., Beckett, R. and Page, M. (2003) ‘Structure-activity relationships in the inactivation of elastase by ?-sultam ’ Organic and Biomolecular Chemistry , 1 (1), pp. 67-80. ISSN 1477-0539
Wood, J. and Page, M. (2002) ‘The mechanisms of sulfonyl transfer in strained cyclic sulfonamides ’ Trends in Heterocyclic Chemistry , 8, pp. 19-34. ISSN 0972-432X
Page, M (2002) ‘Understanding metallo ?-lactamases ’ American Society for Microbiology News , 68 (5), pp. 217-221.
Wood, J., Hinchliffe, P., Laws, A. and Page, M. (2002) ‘Reactivity and the mechanism of reactions of ?-sultams with Nucleophiles’ Journal of the Chemical Society Perkins Transactions 2 , pp. 938-946. ISSN 1364-5471
Sykes, N., Macdonald, S. and Page, M. (2002) ‘Acylating agents as enzyme inhibitors and understanding their reactivity for drug design ’ Journal of Medicinal Chemistry , 45 (13), pp. 2850-2856. ISSN 0022-2623
Wood, J., Hinchliffe, P., Davis, A., Austin, R. and Page, M. (2002) ‘Hydrolysis of a sulfonamide by a novel elimination mechanism generated by carbanion formation in the leaving group ’ Chemical Communications , pp. 772-773. ISSN 1364-548X
Hadfield, P., Casey, L., Galt, R., Vilanova, B. and Page, M. (2002) ‘Imide and isatin derivatives as ?-lactam mimics of ?-lactam antibiotics ’ ARKIVOC , vi, pp. 125-144. ISSN 1424-6376
Seny, D., Prosperi-Meys, C., Bebrone, C., Rossolini, G., Page, M., Noel, P., Frere, J. and Galleni, M. (2002) ‘Mutational analysis of the two zinc binding sites of the Bacillus cereus 569/H/9 metallo-?-lactamase ’ Biochemical Journal , 363, pp. 687-696. ISSN 0264-6021
Beardsell, M., Hinchliffe, P., Wood, J., Wilmouth, R., Schofield, C. and Page, M. (2001) ‘ ?-sultams - a novel class of serine protease inhibitors ’ Chemical Communications , pp. 497-498. ISSN 1364-548X
Bounaga, S., Galleni, M., Laws, A. and Page, M. (2001) ‘Cysteinyl peptide Inhibitors of Bacillus cereus Zinc ?-Lactamase’ Bioorganic & Medicinal Chemistry Letters , 9 (2), pp. 503-507. ISSN 0960-894X
Hinchliffe, P., Wood, J., Davis, A., Austin, R., Beckett, P. and Page, M. (2001) ‘Unusual steric effects in sulfonyl transfer reactions ’ Perkin Transactions 2 , pp. 1503-1505. ISSN 1472-779X
Slater, M., Laws, A. and Page, M. (2001) ‘The relative catalytic efficiency of ?-lactamase catalysed acyl and phosphyl transfer ’ Bioorganic Chemistry , 29, pp. 77-95. ISSN 0045-2068
Allin, S., Vaidya, D., Page, M. and Slawin, A. (2000) ‘Highly diastereoselective synthesis of 2,3-dihydro-9bH- thiazolo[2,3-a]isoindolin-5-ones (00-2016CP) ’ A R K I V O C , 2000, pp. 151-157. ISSN 1551-7004
Breytenbach, J., van Dyk, S., van den Heever, I., Allin, S., Hodkinson, C., Northfield, C. and Page, M. (2000) ‘Synthesis and antimicrobial activity of some isoindolin-1-ones derivatives’ Bioorganic & Medicinal Chemistry Letters , 10 (15), pp. 1629-1635. ISSN 0960894X
Baxter, N., Rigoreau, L., Laws, A. and Page, M. (2000) ‘Reactivity and Mechanism in the Hydrolysis of ?-Sultams’ Journal of the American Chemical Society , 122 (14), pp. 3375-3380. ISSN 1520-5126
Llinás, A., Donoso, J., Vilanova, B., Frau, J., Munoz, F. and Page, M. (2000) ‘Thiol-catalysed hydrolysis of benzylpenicillin’ Journal of the Chemical Society Perkin Transactions 2 (7), pp. 1521-1525. ISSN 1472779X
Page, M. and Laws, A. (2000) ‘The Chemical Reactivity of ?-Lactams, ?-Sultams and ?-Phospholactams’ Tetrahedron , 56 (31), pp. 5631-5637. ISSN 0040-4020
Allin, S., Northfield, C., Page, M. and Slawin, A. (2000) ‘Approaches to the synthesis of non-racemic 3-substituted isoindolinone derivatives’ Journal of the Chemical Society Perkin Transactions 1 (11), pp. 1715-1721. ISSN 14727781
Allin, S., Vaidya, D., Page, M., Slawin, A. and Smith, T. (2000) ‘Highly diastereoselective synthesis and template manipulation of the thiazolo[2,3-a]isoindolin-1-one ring system’ Tetrahedron Letters , 41 (13), pp. 2219-2222. ISSN 0040-4039
Page, M (1999) ‘The Reactivity of b-Lactams, the Mechanism of Catalysis and the Inhibition of b-Lactamases’ Current Pharmaceutical Design , 5 (11), pp. 895-913. ISSN 1381-6128
Rhazi, N., Page, M. and Frere, J. (1999) ‘Peptidase activity of b-lactamases ’ Biochemical Journal , 341 (2), pp. 409-413. ISSN 0264-6021
Baxter, N., Laws, A., Rigoreau, L. and Page, M. (1999) ‘General acid catalysed hydrolysis of ?-sultams involves nucleophilic catalysis’ Chemical Communications (23), pp. 2401-2402. ISSN 1359-7345
Barker, C., Page, M., Korn, S. and Monteith, M. (1999) ‘Esterase catalysed enantioselective ring closure’ Chemical Communications (8), pp. 721-722. ISSN 1359-7345
Allin, S., Northfield, C., Page, M. and Slawin, A. (1999) ‘A new approach to the synthesis of non-racemic isoindolin-1-one derivatives’ Tetrahedron Letters , 40 (1), pp. 141-142. ISSN 0040-4039
Allin, S., Northfield, C., Page, M. and Slawin, A. (1999) ‘A highly diastereoselective synthesis of 3-substituted isoindolin-1-one dericatives’ Tetrahedron Letters , 40 (1), pp. 143-146. ISSN 0040-4039
Llinas, A., Vilanova, B., Frau, J., Munoz, F., Donoso, J. and Page, M. (1998) ‘Chemical Reactivity of Penicillins and Cephalosporins. Intramolecular Involvement of the Acyl-Amido Side Chain’ The Journal of Organic Chemistry , 63 (24), pp. 9052-9060. ISSN 0022-3263
Beard, T. and Page, M. (1998) ‘Enantioselective biotransformations using rhodococci ’ Antonie van Leeuwenhoek , 74 (1/3), pp. 99-106. ISSN 0003-6072
Allin, S., Northfield, C., Page, M. and Slawin, A. (1998) ‘A facile and highly stereoselective approach to a polycyclic isoindolinone ring system via an N-acyliminium ion cyclization reaction’ Tetrahedron Letters , 39 (27), pp. 4905-4908. ISSN 0040-4039
Page, M. and Laws, A. (1998) ‘The mechanism of catalysis and the inhibition of ?-lactamases’ Chemical Communications (16), pp. 1609-1617. ISSN 1359-7345
Bounaga, S., Laws, A., Galleni, M. and Page, M. (1998) ‘The mechanism of catalysis and the inhibition of the Bacillus cereus zinc-dependent b-lactamase ’ Biochemical Journal , 331 (3), pp. 703-711. ISSN 0264-6021
Heathcote, D., Atherton, J., De Boos, G. and Page, M. (1998) ‘Kinetics of ionisation of 3-phenylcoumaran-2-one and reprotonation of the resulting carbanion’ Journal of the Chemical Society, Perkin Transactions 2 (3), pp. 541-546. ISSN 1472-779X
Heathcote, D., De Boos, G., Atherton, J. and Page, M. (1998) ‘Mechanism of hydrolysis of coumaran-2-ones’ Journal of the Chemical Society, Perkin Transactions 2 (3), pp. 535-540. ISSN 1472-779X
Baxter, N. and Page, M. (1997) ‘Evidence for a trigonal bipyramidal intermediate during nucleophilic substitution at a sulfonyl centre and for a sulfonylium cation in the acid catalysed reaction’ Chemical Communications (21), pp. 2037-2038. ISSN 1359-7345
Allin, S., Northfield, C., Page, M. and Slawin, A. (1997) ‘A highly diastereoselective synthesis of tricyclic lactams and their application as novel N-acyl iminium ion precursors in the synthesis of isoindolinone derivatives’ Tetrahedron Letters , 38 (20), pp. 3627-3630. ISSN 0040-4039
Hadfield, P., Galt, R., Sawyer, Y., Layland, N. and Page, M. (1997) ‘An unexpected Mitsunobu reaction. A direct route to the 2,5-diazabicyclo[2.2.1]heptan-3-one skeleton as a ?-lactam mimic of ?-lactam antibiotics’ Journal of the Chemical Society, Perkin Transactions 1 (4), pp. 503-509. ISSN 1472-7781
Baxter, N., Laws, A., Rigoreau, L. and Page, M. (1996) ‘The hydrolytic reactivity of B-sultams’ Journal of the Chemical Society, Perkin Transactions 2 (11), p. 2245. ISSN 1472-779X
Laws, A. and Page, M. (1996) ‘The chemistry and structure-activity relationships of C3-quaternary ammonium cephem antibiotics’ Journal of Chemotherapy , 8, pp. 7-22. ISSN 1120-009X
Page, M., Vilanova, B. and Layland, N. (1995) ‘pH Dependence of and kinetic solvent isotope effects on the methanolysis and hydrolysis of .beta.-lactams catalyzed by class C .beta.-lactamase’ Journal of the American Chemical Society , 117 (49), pp. 12092-12095. ISSN 0002-7863
Layland, N., Laws, A., Vilanova, B. and Page, M. (1995) ‘Penicillin 3-aldehyde is a good substrate and not an inhibitor of ?-lactamases A and C’ Journal of the Chemical Society, Perkin Transactions 2 (5), pp. 869-870. ISSN 1472-779X
Page, M., Laws, A., Slater, M. and Stone, J. (1995) ‘Reactivity of ?-lactams and phosphonamidates and reactions with ?-lactamase’ Pure and Applied Chemistry , 67 (5), pp. 711-717. ISSN 0033-4545
Barton, P., Laws, A. and Page, M. (1994) ‘Structure-activity relationships in the esterase-catalysed hydrolysis and transesterification of esters and lactones’ Journal of the Chemical Society, Perkin Transactions 2 (9), pp. 2021-2029. ISSN 1472-779X
Laws, A., Stone, J. and Page, M. (1994) ‘Large rate enhancement for the hydrolysis of a four-membered ring phosphonamidate’ Chemical Communications (10), pp. 1223-1224. ISSN 1359-7345
Barton, P. and Page, M. (1993) ‘The esterase catalysed resolution of lactones and spirodilactone’ Journal of the Chemical Society, Perkin Transactions 2 (12), pp. 2317-2318. ISSN 1472-779X
Laws, A., Page, M. and Slater, M. (1993) ‘The mechanism of reactions catalysed by the serine ?-lactamases’ Bioorganic & Medicinal Chemistry Letters , 3 (11), pp. 2317-2322. ISSN 0960-894X
Page, M (1993) ‘Reactions of Aldehydes and Ketones and their Derivatives’. In: Organic Reaction Mechanisms. : John Wiley & Sons. pp. 1-16. ISBN 9780471953371
Laws, A., Layland, N., Proctor, D. and Page, M. (1993) ‘The roles of the carboxy group in ?-lactam antibiotics and lysine 234 in ?-lactamase I’ Journal of the Chemical Society, Perkin Transactions 2 (1), pp. 17-21. ISSN 1472-779X
Casey, L., Galt, R. and Page, M. (1993) ‘The mechanisms of hydrolysis of the ?-lactam isatin and its derivatives’ Journal of the Chemical Society, Perkin Transactions 2 (1), pp. 23-28. ISSN 1472-779X
Barton, P. and Page, M. (1992) ‘The resolution of racemic 1,2-diols by the esterase catalysed hydrolysis of the corresponding cyclic carbonate’ Tetrahedron , 48 (36), pp. 7731-7734. ISSN 0040-4020
Page, M (1992) ‘Reactions of Aldehydes and Ketones and their Derivatives’. In: Organic Reaction Mechanisms. : John Wiley & Sons. pp. 1-15. ISBN 9780471942245
Page, M (1992) ‘The mechanisms of reactions of(beta)lactams’. In: The chemistry of Beta lactams. London: Blackie Academic and Professional. pp. 129-147. ISBN 9780751400618
Page, M (1992) ‘Structure-activity relationships : chemical’. In: The chemistry of (beta) lactams. London: Blackie Academic and Professional. pp. 79-100. ISBN 9780751400618
Davis, A., Proctor, P. and Page, M. (1991) ‘Alcohol-catalysed hydrolysis of benzylpenicillin’ Journal of the Chemical Society, Perkin Transactions 2 (8), pp. 1213-1217. ISSN 1472-779X
Davis, A., Layland, N., Page, M., Martin, F. and O'Ferrall, R. (1991) ‘Thiazolidine ring opening in penicillin derivatives. Part 2. Enamine formation’ Journal of the Chemical Society, Perkin Transactions 2 (8), pp. 1225-1229. ISSN 1472-779X
Davis, A., Jones, M. and Page, M. (1991) ‘Thiazolidine ring opening in penicillin derivatives. Part 1. Imine formation’ Journal of the Chemical Society, Perkin Transactions 2 (8), pp. 1219-1223. ISSN 1472-779X
Page, M (1991) ‘Reactions of Aldehydes and Ketones and their Derivatives’. In: Organic Reaction Mechanisms. : John Wiley & Sons. pp. 1-20. ISBN 9780471937944
Page, M (1991) ‘The Energetics of Intramolecular Reactions and Enzyme Catalysis’ Philosophical Transactions of the Royal Society B: Biological Sciences , 332 (1263), pp. 149-156. ISSN 0962-8436
Jones, M. and Page, M. (1991) ‘An esterase with ?-lactamase activity’ Chemical Communications (5), pp. 316-317. ISSN 1359-7345
Davies, K. and Page, M. (1990) ‘Reaction rates and thermodynamic equilibration of tetrahedral intermediates: the alcoholysis of cephalosporins’ Chemical Communications (20), pp. 1448-1450. ISSN 1359-7345
Page, M (1990) ‘Reactions of Aldehydes and Ketones and their Derivatives’. In: Organic Reaction Mechanisms. : John Wiley & Sons. pp. 1-18. ISBN 9780471931034
Page, M., Webster, P. and Ghosez, L. (1990) ‘The hydrolysis of azetidinyl amidinium salts. Part 2. Substituent effects, buffer catalysis, and the reaction mechanism’ Journal of the Chemical Society, Perkin Transactions 2 (5), pp. 813-823. ISSN 1472-779X
Page, M., Webster, P. and Ghosez, L. (1990) ‘The hydrolysis of azetidinyl amidinium salts. Part 1. The unimportance of strain release in the four-membered ring’ Journal of the Chemical Society, Perkin Transactions 2 (5), pp. 805-811. ISSN 1472-779X
Page, M. and Laws, A. (1990) ‘Molecular recognition in beta lactamases’. In: Molecular mechanisms in bioorganic processes. : Royal Society of Chemistry. pp. 319-330. ISBN 9780851869469
Laws, A. and Page, M. (1989) ‘The effect of the carboxy group on the chemical and ?-lactamase reactivity of ?-lactam antibiotics’ Journal of the Chemical Society, Perkin Transactions 2 (10), pp. 1577-1581. ISSN 1472-779X
Page, M (1989) ‘Reactions of Aldehydes and Ketones and their Derivatives’. In: Organic Reaction Mechanisms. : John Wiley & Sons. pp. 1-20. ISBN 9780471928256
Jones, M., Buckwell, S., Page, M. and Wrigglesworth, R. (1989) ‘A reversible inhibitor of ?-lactamase I from Bacillus cereus ’ Chemical Communications (2), pp. 70-71. ISSN 1359-7345
Buckwell, S., Page, M., Longridge, J. and Waley, S. (1988) ‘Hydrolysis of 3-substituted cephalosporins catalysed by ?-lactamases I and II from Bacillus cereus and by hydroxide ion’ Journal of the Chemical Society, Perkin Transactions 2 (10), pp. 1823-1827. ISSN 1472-779X
Buckwell, S., Page, M. and Longridge, J. (1988) ‘Hydrolysis of 6-alkyl penicillins catalysed by ?-lactamase I from Bacillus cereus and by hydroxide ion’ Journal of the Chemical Society, Perkin Transactions 2 (10), pp. 1809-1813. ISSN 1472-779X
Buckwell, S., Page, M., Waley, S. and Longridge, J. (1988) ‘Hydrolysis of 7-substituted cephalosporins catalysed by ?-lactamases I and II from Bacillus cereus and by hydroxide ion’ Journal of the Chemical Society, Perkin Transactions 2 (10), pp. 1815-1821. ISSN 1472-779X
Page, M (1988) ‘Reactions of Aldehydes and Ketones and their Derivatives’. In: Organic Reaction Mechanisms. : John Wiley & Sons. pp. 1-22. ISBN 9780471920298
Page, M (1988) ‘Energy differences and their relevance to enzyme and intramolecular catalysis’ Journal of Molecular Catalysis A: Chemical , 47, pp. 241-253. ISSN 1381-1169
Page, M., Webster, P., Ghosez, L. and Bogden, S. (1988) ‘The ease of C-N bond fission in azetidine derivatives’ Actualite Chimique, L' , pp. 272-276. ISSN 0151-9093
Page, M (1987) ‘The Mechanisms of Reactions of ?-Lactam Antibiotics’. In: Advances in Physical Organic Chemistry Volume 23. : Academic Press. pp. 165-270. ISBN 9780120335237
Sheldrick, B., Akrigg, D., Page, M. and Cox, G. (1987) ‘Structures of carbocyclic analogues of penicillin. 3. N-(Bicyclo[3.2.0]hept-2-ene-6-spiro-2'-dioxolane-7-yl)phthalimide’ Acta Crystallographica Section C Crystal Structure Communications , 43 (3), pp. 595-597. ISSN 0108-2701
Page, M (1987) ‘Reactions of Aldehydes and Ketones and their Derivatives’. In: Organic Reaction Mechanisms. : John Wiley & Sons. pp. 1-27. ISBN 9780471920786
Sheldrick, B., Akrigg, D., Page, M. and Cox, G. (1987) ‘Structures of carbocyclic analogues of penicillin. 2. N-(3,4-Dihydroxy-7-oxobicyclo[3.2.0]hept-6-yl)succinimide’ Acta Crystallographica Section C Crystal Structure Communications , 43 (3), pp. 594-595. ISSN 0108-2701
Page, M (1987) ‘Reactions of Aldehydes and Ketones and their Derivatives’. In: Organic Reaction Mechanisms. : John Wiley & Sons. pp. 1-27. ISBN 9780471920786
Page, M., Webster, P., Bogdan, S., Tremerie, B. and Ghosez, L. (1987) ‘Ease of C-N bond cleavage in four-membered rings’ Chemical Communications (5), pp. 318-319. ISSN 1359-7345
Buckwell, S., Page, M. and Longridge, J. (1986) ‘Equilibria between enamine and B-unsaturated imine in cephalosporin hydrolysis’ Chemical Communications (13), pp. 1039-1040. ISSN 1359-7345
Agathocleous, D., Cox, G. and Page, M. (1986) ‘Stereochemistry and ring opening of a carbocyclic analogue of a 1-oxapenam’ Tetrahedron Letters , 27 (14), pp. 1631-1634. ISSN 0040-4039
Page, M., Render, D. and Bernath, G. (1986) ‘Stereochemical studies. Part 112. Geometrical dependence of intramolecular catalysis in the hydrolysis and aminolysis of aryl esters’ Journal of the Chemical Society, Perkin Transactions 2 (6), pp. 867-871. ISSN 1472-779X
Page, M (1986) ‘Reactions of Aldehydes and Ketones and their Derivatives’. In: Organic Reaction Mechanisms. : John Wiley & Sons. pp. 1-27. ISBN 9780471917298
Sheldrick, B., Akrigg, D., Page, M. and Agathocleous, D. (1985) ‘Structure of a carbocyclic oxapenam analogue’ Acta Crystallographica Section C Crystal Structure Communications , 41 (12), pp. 1816-1817. ISSN 0108-2701
Davis, A. and Page, M. (1985) ‘Opening of the thiazolidine ring of penicillin derivatives’ Chemical Communications (23), pp. 1702-1704. ISSN 1359-7345
Sheldrick, B., Akrigg, D., Page, M. and Agathocleous, D. (1985) ‘Structure of a carbocyclic analogue of penicillin’ Acta Crystallographica Section C Crystal Structure Communications , 41 (6), pp. 942-944. ISSN 0108-2701
Davis, A., Page, M., Mason, S. and Watt, I. (1984) ‘The effective concentration of a hydride transfer reaction’ Chemical Communications (24), pp. 1671-1672. ISSN 1359-7345
Sheldrick, B., Akrigg, D., Page, M. and Agathocleous, D. (1984) ‘N-{(1R*,5S*,7R*)-6-Oxobicyclo[3.2.0]hept-2-en-7-yl}phthalimide, C15H11NO3’ Acta Crystallographica Section C Crystal Structure Communications , 40 (7), pp. 1217-1219. ISSN 0108-2701
Page, M (1984) ‘Chapter 7 The mechanisms of chemical catalysis used by enzymes’. In: New Comprehensive Biochemistry. : Elsevier BV. pp. 229-269. ISBN 9780444805041
Page, M (1984) ‘Chapter 1 The energetics and specificity of enzyme—substrate interactions’. In: New Comprehensive Biochemistry. : Elsevier BV. pp. 1-54. ISBN 9780444805041
Page, M (1984) ‘Reactions of Aldehydes and Ketones and their Derivatives’. In: Organic Reaction Mechanisms. : John Wiley & Sons. pp. 1-32. ISBN 9780471907978
Page, M. and Crombie, D. (1984) ‘Reactions in macromolecular systems’. In: Macromolecular Chemistry. : Royal Society of Chemistry. pp. 351-374. ISBN 9780-851868769
Page, M. and Proctor, P. (1984) ‘Mechanism of .beta.-lactam ring opening in cephalosporins’ Journal of the American Chemical Society , 106 (13), pp. 3820-3825. ISSN 0002-7863
Page, M (1984) ‘The mechanisms of reactions of .beta.-lactam antibiotics’ Accounts of Chemical Research , 17 (4), pp. 144-151. ISSN 0001-4842
Page, M (1983) ‘Reactions of Aldehydes and Ketones and their Derivatives’. In: Organic Reaction Mechanisms. : John Wiley & Sons. pp. 1-32. ISBN 9780471905035
Proctor, P., Gensmantel, N. and Page, M. (1982) ‘The chemical reactivity of penicillins and other b-lactam antibiotics’ Journal of the Chemical Society, Perkin Transactions 2 (9), pp. 1185-1192. ISSN 1472-779X
Crombie, D. and Page, M. (1982) ‘Reactions in macromolecular systems’. In: Macromolecular Chemistry. : Royal Society of Chemistry. pp. 322-346. ISBN 9780851868660
Page, M (1982) ‘Reactions of Aldehydes and Ketones and Their Derivatives’. In: Organic Reaction Mechanisms. : John Wiley & Sons. pp. 1-17. ISBN 9780471902027
Gensmantel, N. and Page, M. (1982) ‘The micelle-catalysed hydrolysis of benzylpenicillin’ Journal of the Chemical Society, Perkin Transactions 2 (2), pp. 147-153. ISSN 1472-779X
Gensmantel, N. and Page, M. (1982) ‘The effect of increasing the hydrophobicity of penicillin on its micelle-catalysed hydrolysis’ Journal of the Chemical Society, Perkin Transactions 2 (2), pp. 155-159. ISSN 1472-779X
Page, M (1981) ‘Reactions of Aldehydes and Ketones and Their Derivatives’. In: Organic Reaction Mechanisms. : John Wiley & Sons. pp. 1-21. ISBN 9780471104599
Gosney, A. and Page, M. (1980) ‘The mechanism of nitrosation of 4-nitrophenol with aqueous nitrous acid’ Journal of the Chemical Society, Perkin Transactions 2 (12), pp. 1783-1787. ISSN 1472-779X
Gensmantel, N., Proctor, P. and Page, M. (1980) ‘Metal-ion catalysed hydrolysis of some ?-lactam antibiotics’ Journal of the Chemical Society, Perkin Transactions 2 (11), pp. 1725-1732. ISSN 1472-779X
Page, M (1980) ‘Transition states, standard states and enzymic catalysis’ International Journal of Biochemistry , 11 (5), pp. 331-335. ISSN 1357-2725
Morris, J. and Page, M. (1980) ‘Intramolecular nucleophilic and general acid catalysis in the hydrolysis of an amide. Some comments on the mechanism of catalysis by serine proteases’ Journal of the Chemical Society, Perkin Transactions 2 (7), pp. 1131-1136. ISSN 1472-779X
Morris, J. and Page, M. (1980) ‘Hydroxy-group participation in the hydrolysis of amides and its effective concentration in the absence of strain effects’ Journal of the Chemical Society, Perkin Transactions 2 (4), pp. 679-684. ISSN 1472-779X
Morris, J. and Page, M. (1980) ‘Structure-reactivity relationships and the mechanism of general base catalysis in the hydrolysis of a hydroxy-amide. Concerted breakdown of a tetrahedral intermediate’ Journal of the Chemical Society, Perkin Transactions 2 (4), pp. 685-692. ISSN 1472-779X
Morris, J. and Page, M. (1980) ‘Intra- and inter-molecular catalysis in the aminolysis of benzylpenicillin’ Journal of the Chemical Society, Perkin Transactions 2 (1), pp. 212-219. ISSN 1472-779X
Morris, J. and Page, M. (1980) ‘Buffer catalysis in the hydrazinolysis of benzylpenicillin’ Journal of the Chemical Society, Perkin Transactions 2 (1), pp. 220-224. ISSN 1472-779X
Page, M (1979) ‘The principles of enzymatic catalysis’ International Journal of Biochemistry , 10 (6), pp. 471-476. ISSN 1357-2725
Martin, A., Morris, J. and Page, M. (1979) ‘Intramolecular general acid catalysis in the aminolysis of benzylpenicillin. A preferred direction of nucleophilic attack’ Chemical Communications (6), pp. 298-299. ISSN 1359-7345
Gensmantel, N. and Page, M. (1979) ‘The aminolysis of penicillin derivatives. Rate constants for the formation and breakdown of the tetrahedral addition intermediate’ Journal of the Chemical Society, Perkin Transactions 2 (2), pp. 137-142. ISSN 1472-779X
Morris, J. and Page, M. (1978) ‘Intramolecular nucleophilic and general acid catalysis in the hydrolysis of an amide’ Chemical Communications (14), pp. 591-591. ISSN 1359-7345
Gensmantel, N. and Page, M. (1978) ‘A tetrahedral intermediate in the aminolysis of benzylpenicillin’ Chemical Communications (9), pp. 374-375. ISSN 1359-7345
Gensmantel, N., Gowling, E. and Page, M. (1978) ‘Metal ion catalysis in the aminolysis of penicillin’ Journal of the Chemical Society, Perkin Transactions 2 (4), pp. 335-342. ISSN 1472-779X
Page, M (1977) ‘Entropy, Binding Energy, and Enzymic Catalysis’ Angewandte Chemie International Edition , 16 (7), pp. 449-459. ISSN 1433-7851
Page, M (1976) ‘Binding energy and enzymic catalysis’ Biochemical and Biophysical Research Communications , 72 (2), pp. 456-461. ISSN 0006-291X
Martin, A., Morris, J. and Page, M. (1976) ‘Intra-and inter-molecular general base catalysis in the aminolysis of benzylpenicillin’ Chemical Communications (13), pp. 495-496. ISSN 1359-7345
Page, M (1975) ‘Reactions of Acids and their Derivatives’. In: Organic Reaction Mechanisms. : John Wiley & Sons. pp. 23-79. ISBN 9780471018643
Page, M (1974) ‘Reactions of Acids and their Derivatives’. In: Organic Reaction Mechanisms. : John Wiley & Sons. pp. 23-67. ISBN 9780471126935
Jencks, W. and Page, M. (1974) ‘Orbital steering, entropy, and rate accelerations’ Biochemical and Biophysical Research Communications , 57 (3), pp. 887-892. ISSN 0006-291X
Bell, R., Critchlow, J. and Page, M. (1974) ‘Ground state and transition state effects in the acylation of a-chymotrypsin in organic solvent-water mixtures’ Journal of the Chemical Society, Perkin Transactions 2 (1), pp. 66-70. ISSN 1472-779X
Bell, R. and Page, M. (1973) ‘Intramolecular general acid catalysis in the halogenation of ketones’ Journal of the Chemical Society, Perkin Transactions 2 (12), pp. 1681-1686. ISSN 1472-779X
Page, M (1973) ‘The energetics of neighbouring group participation’ Chemical Society Review , 2 (3), pp. 295-323. ISSN 0306-0012
Page, M (1973) ‘Reactions of Acids and Their Derivatives’. In: Organic Reaction Mechanisms. : John Wiley & Sons. pp. 21-60. ISBN 9780471126904
Page, M. and Jencks, W. (1972) ‘General base and acid catalysis in the hydrazinolysis of acetylimidazole’ Journal of the American Chemical Society , 94 (25), pp. 8828-8838. ISSN 0002-7863
Page, M. and Jencks, W. (1972) ‘Intramolecular general base catalysis in the aminolysis of acetylimidazole and methyl formate by diamines’ Journal of the American Chemical Society , 94 (25), pp. 8818-8827. ISSN 0002-7863
Page, M (1972) ‘Entropic rate accelerations and orbital steering’ Biochemical and Biophysical Research Communications , 49 (4), pp. 940-944. ISSN 0006-291X
Capon, B. and Page, M. (1972) ‘Intramolecular nucleophilic assistance in the reactions of O,O'-benzylidene catechols’ Journal of the Chemical Society, Perkin Transactions 2 (14), pp. 2057-2062. ISSN 1472-779X
Fox, J., Page, M., Satterthwait, A. and Jencks, W. (1972) ‘Nonlinear broensted relation for general acid-base catalysis of aminolysis reactions’ Journal of the American Chemical Society , 94 (13), pp. 4729-4732. ISSN 0002-7863
Capon, B., Page, M. and Sankey, G. (1972) ‘The kinetics and mechanism of the hydrolysis of 2,3-(phenylmethylenedioxy)benzoic acid (OO?-benzylidene-2,3-dihydroxybenzoic acid)’ Journal of the Chemical Society, Perkin Transactions 2 (5), pp. 529-532. ISSN 1472-779X
Capon, B. and Page, M. (1972) ‘The kinetics and mechanism of the hydrolysis of 2,3-(phenylmethylenedioxy)benzene (Oo'-benzylidenecatechol) and benzaldehyde diphenyl acetal’ Journal of the Chemical Society, Perkin Transactions 2 (5), pp. 522-529. ISSN 1472-779X
Page, M. and Jencks, W. (1972) ‘Uncatalyzed aminolysis of acetylimidazole. Limiting product-like transition state for acyl transfer’ Journal of the American Chemical Society , 94 (9), pp. 3263-3264. ISSN 0002-7863
Page, M. and Jencks, W. (1971) ‘Entropic Contributions to Rate Accelerations in Enzymic and Intramolecular Reactions and the Chelate Effect’ National Academy of Sciences. Proceedings , 68 (8), pp. 1678-1683. ISSN 0027-8424
Capon, B. and Page, M. (1971) ‘The kinetics and mechanism of the hydrolysis of esters of cis- and trans-2-hydroxycyclopentanecarboxylic acid and 3-hydroxybutyric acid’ Journal of the Chemical Society B, physical organic , pp. 741-744. ISSN 1472-779X
Capon, B. and Page, M. (1970) ‘The mechanism of hydrolysis of 2,3-OO-benzylidene-norbornane-exo-2,-exo-3-diols’ Journal of the Chemical Society D: Chemical Communications (21), pp. 1443-1444. ISSN 0577-6171
Areas of research supervision include:
