Dr Paul Humphreys
firstname.lastname@example.org | 01484 472771
I am a practical microbiologist with over 25 years experience working at the interface between research and industry. I have two independent research themes: firstly disinfection and infection control and secondly radioactive waste disposal. In the case of disinfection and infection control I manage an industry focussed research and consultancy group the Hygiene and Disinfection Centre which has assisted a wide range of companies to take their products from the lab bench to the marketplace. For more information regarding the Hygiene and Disinfection Centre please visit our web site.
In the case of radioactive waste disposal I have a longstanding profile as a national and international expert in gas generation and the impact of microbiology on the performance of radioactive waste disposal facilities. Much of my current research is focused on the fate, transport and biosphere impacts of Carbon-14 and I am PI for the C14-BIG project a joint NDA/EPSRC grant on the disposal of reactor graphite and associated Carbon-14.For more information on the C14-BIG project please visit the project Website.
In conjunction with the carbohydrate research group (CRG) I also have a range of research projects on the generation and biodegradation of complexants such as iso-saccharinic acids. The CRG has a unique suite of analytical techniques for the analysis of cellulose, it's degradation and subsequent degradation products which underpins our research in this area.
Research & Scholarship
I have a range of research interests in applied and environmental microbiology. These include: Development and testing of bactericidal, sporicidal and fungicidal products for medical, industrial and domestic markets Anaerobic degradation of pollutants and polymers and currently have research ongoing on anaerobic cellulolytic fungi and the degradation of amide wastes. Fate and transport of metal pollutants through the biosphere and the role of microbes in facilitating and attenuating this transport. Contaminated land remediation including phytoremediation.
Publications and Other Research Outputs
Alhudhud, M., Humphreys, P. and Laws, A. (2014) ‘Development of A Growth Medium Suitable for Exopolysaccharide Production and Structural Characterisation by Bifidobacteria animalis ssp. lactis’ Journal of Microbiological Methods , 100, pp. 93-98. ISSN 0167-7012
Humphreys, P., Davies, C. and Rout, S. (2014) ‘An evaluation of the infection control potential of a UV clinical podiatry unit’ Journal of Foot and Ankle Research , 7 (17). ISSN 1757-1146
Patten, D., Leivers, S., Chadha, M., Maqsood, M., Humphreys, P., Laws , A. and Collett, A. (2014) ‘The structure and immunomodulatory activity on intestinal epithelial cells of the EPSs isolated from Lactobacillus helveticus sp. Rosyjski and Lactobacillus acidophilus sp. 5e2.’ Carbohydrate Research , 384, pp. 119-127. ISSN 00086215
Denton, A., Topping, A. and Humphreys, P. (2014) ‘Managing Clostridium difficile infection in hospitalised patients’ Nursing Standard , 28 (33), pp. 37-43. ISSN 0029-6570
Alyazouri, A., Jewsbury, R., Hassan, A., Humphreys, P. and Al-Sayah, M. (2014) ‘Phytoextraction of Cr(VI) from soil using Portulaca oleracea ’ Toxicological & Environmental Chemistry . ISSN 1029-0486
Alyazouri, A., Jewsbury, R., Tayim, H., Humphreys, P. and Al-Sayah, M. (2013) ‘Applicability of heavy-metal phytoextraction in United Arab Emirates: an investigation of candidate species ’ Soil and Sediment Contamination: An International Journal . ISSN 1549-7887
Humphreys, P. and Pilling, S. (2013) ‘The surface disinfection efficiency of sporicidal products ’. In: IPS 2013, 30th September - 2nd October 2013, London, UK
Humphreys, P. and Nightingale , A. (2013) ‘Combining sporicidal products with ultrasonic cleaning ’. In: IPS 2013, 30th September - 2nd October 2013, London, UK
Humphreys, P., Finan, P., Rout, S., Hewitt, J., Thistlethwaite, P., Barnes, S. and Pilling, S. (2013) ‘A systematic evaluation of a peracetic-acid-based high performance disinfectant’ Journal of Infection Prevention , 14 (4), pp. 126-131. ISSN 1757-1774
Humphreys, P., Finan, P., Rout, S., Hewitt, J., Thistlethwaite, P., Barnes, S. and Pilling, S. (2013) ‘A systematic evaluation of a peracetic-acid-based high performance disinfectant’ Journal of Infection Prevention . ISSN 1757-1774
Almond, M., Shaw, P., Humphreys, P., Chadha, M., Niemelä, K. and Laws, A. (2012) ‘Behavior of xyloisosaccharinic acid and xyloisosaccharino-1,4-lactone in aqueous solutions at varying pHs’ Carbohydrate Research , 363, pp. 51-57. ISSN 00086215
White, S., Topping, A., Humphreys, P., Rout, S. and Williamson, H. (2012) ‘The cross-contamination potential of mobile telephones’ Journal of Research in Nursing , 17 (6), pp. 582-595. ISSN 1744-9871
Humphreys, P (2012) The Potential Role of Fungi and Algae in the Atmospheric Corrosion of Waste Packages in Interim Storage and During the Operational Period of a GDF Oxfordshire, UK: Nuclear Decommissioning Authority
Humphreys, P., Hook , J. and Rout, S. (2012) ‘Evaluation of the cleaning efficiency of microfibre cloths processed via an ozonated laundry system’ Journal of Infection Prevention , 13 (4), pp. 104-108. ISSN 1757-1774
Humphreys, P (2012) ‘A robust method for the synthesis and isolation of ?-gluco-isosaccharinic acid ((2R,4S)-2,4,5-trihydroxy-2-(hydroxymethyl)pentanoic acid) from cellulose and measurement of its aqueous pKa’ Carbohydrate Research , 349, pp. 6-11. ISSN 00086215
Finan, P. and Humphreys, P. (2012) ‘Diff-X: A High Performance Alternative to Chlorine Based Disinfectants’. In: IPS 2012, 1st - 3rd October 2012, Liverpool, UK
Avis, J., West, A., Walsh, R., Calder, R., Suckling, P., Humphreys, P. and King, F. (2011) ‘Detailed Modelling for the Postclosure Safety Assessment of OPGs DGR.’. In: Waste Management, Decommissioning and Environmental Restoration for Canadas Nuclear Activities , Sep 11 - Sep 14 2011, Ontario, Canada , p. 27
King , F., Humphreys, P. and Metcalfe, R. (2011) A Review of the Information Available to Assess the Risk of Microbiologically Influenced Corrosion in Waste Packages Nuclear Decommissioning Authority (NDA)
Humphreys, P (2011) ‘Testing Standards for Sporicides’ Journal of Hospital Infection , 77 (3), pp. 193-198. ISSN 0195-6701
Avis, J., Calder, N., Humphreys, P., King, F., Suckling, P. and Walsh, R. (2011) Postclosure Safety Assessment: Gas Modelling Canada: NWMO, Ontario, Canada
Walke, R., Humphreys, P., King, F., Little, R., Metcalfe, R., Penfold, J., Towler, G., Walsh, R. and Wilson, J. (2011) Postclosure Safety Assessment: Data Canada: NWMO, Ontario, Canada
Little, R., Humphreys, P., King, F., Metcalfe, R., Penfold, J., Suckling, P., Towler, G., Walke, R. and Wilson , J. (2011) Postclosure Safety Assessment: System and its Evolution Canada: NWMO, Ontario, Canada
Suckling, P., Avis, J., Humphreys, P. and King, F. (2011) T2GGM Version 2: Gas Generation and Transport Code Canada: NWMO, Ontario, Canada
Smart, N. and Humphreys, P. (2011) Information on Potential Sources and Sinks for Hydrogen in UK HLW and SF Geological Disposal Facility NDA RWMD
Little, R., Avis, J., Garisto, N., Humphreys, P., King, F., Metcalfe, R., Penfold, J., Ramlakan, A., Suckling, P. and Towler, G. (2011) Postclosure Safety Assessment Canada: NWMO, Ontario, Canada.
Humphreys, P., Laws, A. and Dawson, J. (2010) A Review of Cellulose Degradation and the Fate of Degradation Products Under Repository Conditions Cumbria, UK: Nuclear Decommissioning Authority (NDA)
Humphreys, P., West, J. and Metcalfe, R. (2010) Microbial Effects on Repository Performance UK: UK NDA
Suckling, P., Calder, N., Humphreys, P., Fraser, K. and Leung, H. (2009) ‘The development and use of T2GGM: a gas modelling code for the postclosure safety assessment of opg's proposed l&ilw deep geologic repository, Canada’. In: 2009 Proceedings of the ASME 12th International Conference on Environmental Remediation and Radioactive Waste Management-CD-ROM. New York, USA: ASME. pp. 1-10. ISBN 978079183865X
Walke, R., Bath, A., Savage, D., Towler, G., Walsh, R., Bond, A., Calder, N., Humphreys, P., King, F., Little, R., Metcalfe, R., Penfold, J. and Rees, J. (2009) Postclosure safety assessment (V1): data Nuclear Waste Management Organization
Calder, N., Avis, J., Humphreys, P., King, F., Suckling, P. and Walsh, R. (2009) Postclosure safety assessment (V1): gas modelling Nuclear Waste Management Organization
Little, R., Avis, J., Savage, D., Suckling, P., Towler, G., Walke, R., Walsh, R., Calder, N., Garisto, N., Humphreys, P., King, F., Limer, L., Metcalfe, R., Penfold, J. and Rees, J. (2009) Postclosure safety assessment (V1): report Nuclear Waste Management Organization
Little, R., Bath, A., Humphreys, P., King, F., Metcalfe, R., Penfold, J., Savage, D., Towler, G. and Walke, R. (2009) Postclosure Safety Assessment (V1): System and Its Evolution Nuclear Waste Management Organization
Metcalfe, R., Watson, S., Rees, J., Humphreys, P. and King, F. (2008) Gas generation and migration from a deep geological repository for radioactive waste. A review of Nirex/NDAs work Penrith, Cumbria: NWAT, Environment Agency
Lockhart, R., Van Dyke, M., Beadle, I., Humphreys, P. and McCarthy, A. (2006) ‘Molecular biological detection of anaerobic gut fungi (Neocallimastigales) from landfill sites ’ Applied and Environmental Microbiology , 72 (8), pp. 5659-5661. ISSN 0099-2240
Dutton, M. and Humphreys, P. (2005) ‘Assessing the potential of short rotation coppice (SRC) for cleanup of radionuclide contaminated sites ’ International Journal of Phytoremediation , 7 (4), pp. 279-293. ISSN 1549-7879
Beadle, I., Boult, S., Graham, J., Hand, V., Humphreys, P., Trivedi, D. and Warwick, P. (2004) ‘Near-field/far-field interface of a near-surface low level radioactive waste site’ Materials Research Society Proceedings (835). ISSN 0272-9172
Grundy, C., Humphreys, P. and Strong, R. (2003) ‘Safe management of the contaminated land inventory, Sellafield, UK ’ Nuclear Energy , 42 (5), pp. 279-283. ISSN 0140-4067
Beadle, I., Humphreys, P., Pettit, C. and Small, J. (2001) ‘Integrating microbiology into the Drigg Post-closure radiological safety assessment’ Materials Research Society Proceedings (665). ISSN 0272-9172
Small, J., Randall, M., Abraitis, P. and Humphreys, P. (2000) ‘Modelling the Ion exchange properties of geological materials and implications for radionuclide mobility’. In: Ion Exchange at the Millennium: Proceedings of IEX 2000. London, UK: World Scientific Books. pp. 124-132. ISBN 9781860942327
Small, J., Humphreys, P., Johnstone, T., Plant, R., Randall, M. and Trivedi, D. (2000) ‘Results of an aqueous source term model for a radiological risk assessment of the Drigg LLW site’ Materials Research Society Proceedings (608). ISSN 0272-9172
Binks, P., Fairhurst, A., Smalley, D., Thomson, D., Trivedi, T., Howarth, D., Humphreys, P., Johnstone, T., Jones, M., Kelly, E., Lee, A., McGarry, R. and Randall, M. (1997) ‘An integrated testing programme for a near field radionuclide migration code’ Materials Research Society Proceedings , 506, pp. 613-620. ISSN 0272-9172
Research Degree Supervision
Anaerobic Degradation of cellulose and other polymeric organic materials
The degradation of polymeric materials is an important aspect of anaerobic microbiology since it contributes to biogas generation, animal nutrition and the environmental fate of man made materials. I currently have a number of ongoing research projects investigating the anaerobic degradation of cellulose and plastic additives and expect to continue to carry out research in these areas.
Development and testing of biocidal products
The development of novel biocidal products aimed at emerging infections and spore forming bacteria such as C. difficile are of particular interest to my research group.
Degradation of Radioactive Wastes
Many radioactive wastes are amenable to microbial degradation. This degradation is often associated with gas generation and the production of metabolites which may influence radionuclide mobility. The modelling and investigation of the degradation of organic radioactive wastes is an area of active research.