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Dr P McHugh completed his PhD in Pharmacogenomics at the University of Otagos (New Zealand) Christchurch School of Medicine in 2006. He undertook Postdoctoral work in the University of Otagos Department of Pathology and subsequent work as a Research Fellow in the Universitys Carney Centre for Pharmacogenomics. For the past few years he has been working as a Research Scientist in the University of Baths Department of Biochemistry. In late 2011 he joined the University of Huddersfield as a Senior Research Fellow in the School of Applied Sciences Division of Pharmacy & Pharmaceutical Sciences focusing on several areas of research including CNS drug development and mental health neuroscience.
Dr McHugh research interests include;
1. The development of novel compounds for the treatment of neuropathic pain, neurodegenerative disorders & psychiatric disease.
2. The development of disease biomarkers.
3. The mechanism of action of CNS drugs.
4. The aetiology of neuropathic pain, neurodegenerative disorders & psychiatric disease.
McHugh, P., Wright, J., Williams, R. and Brown, D. (2012) ‘Prion Protein Expression Alters APP Cleavage without Interaction with BACE-1’ Neurochemistry International , 61 (5), pp. 672-680. ISSN 01970186
McHugh, P (2011) ‘The tetrahydrobiopterin pathway: a novel target for the treatment of depression’ Pharmacogenomics , 12 (12), pp. 1625-1627. ISSN 1462-2416
Davies, P., McHugh, P., Hammond, V., Marken, F. and Brown, D. (2011) ‘Contribution of Individual Histidines to Prion Protein Copper Binding’ Biochemistry , 50 (50), pp. 10781-10791. ISSN 0006-2960
McHugh, P., Joyce, P., Deng, X. and Kennedy, M. (2011) ‘A polymorphism of the GTP-cyclohydrolase I feedback regulator gene alters transcriptional activity and may affect response to SSRI antidepressants’ The Pharmacogenomics Journal , 11 (3), pp. 207-213. ISSN 1470-269X
McHugh, P., Wright, J. and Brown, D. (2011) ‘Transcriptional Regulation of the Beta-Synuclein 5?-Promoter Metal Response Element by Metal Transcription Factor-1’ PLoS ONE , 6 (2), p. 17354. ISSN 1932-6203
McHugh, P (2010) ‘Tetrahydrobiopterin Pathway may Provide Novel Molecular Targets for Acute and Long Term Efficacy of Mood-Regulating Drugs ’ Current Pharmacogenomics and Personalized Medicine , 8 (3), pp. 174-181. ISSN 1875-6921
McHugh, P., Rogers, G., Glubb, D., Joyce, P. and Kennedy, M. (2010) ‘Proteomic analysis of rat hippocampus exposed to the antidepressant paroxetine’ Journal of Psychopharmacology , 24 (8), pp. 1243-1251. ISSN 0269-8811
Glubb, D., McHugh, P., Deng, X., Joyce, P. and Kennedy, M. (2010) ‘Association of a functional polymorphism in the adrenomedullin gene (ADM) with response to paroxetine’ The Pharmacogenomics Journal , 10 (2), pp. 126-133. ISSN 1470-269X
Wright, J., McHugh, P., Stockbridge, M., Lane, S., Kralovicova, S. and Brown, D. (2009) ‘Activation and repression of prion protein expression by key regions of intron 1’ Cellular and Molecular Life Sciences , 66 (23), pp. 3809-3820. ISSN 1420-682X
Joyce, P., McHugh, P., Light, K., Rowe, S., Miller, A. and Kennedy, M. (2009) ‘Relationships Between Angry-Impulsive Personality Traits and Genetic Polymorphisms of the Dopamine Transporter’ Biological Psychiatry , 66 (8), pp. 717-721. ISSN 0006-3223
McHugh, P., Joyce, P. and Kennedy, M. (2009) ‘Polymorphisms of sepiapterin reductase gene alter promoter activity and may influence risk of bipolar disorder’ Pharmacogenetics and Genomics , 19 (5), pp. 330-337. ISSN 1744-6872
McHugh, P., Rogers, G., Glubb, D., Allington, M., Hughes, M., Joyce, P. and Kennedy, M. (2008) ‘Downregulation ofCcnd1 and Hes6in rat hippocampus after chronic exposure to the antidepressant paroxetine’ Acta Neuropsychiatrica , 20 (6), pp. 307-313. ISSN 0924-2708
McHugh, P., Rogers, G., Loudon, B., Glubb, D., Joyce, P. and Kennedy, M. (2008) ‘Proteomic analysis of embryonic stem cellderived neural cells exposed to the antidepressant paroxetine’ Journal of Neuroscience Research , 86 (2), pp. 306-316. ISSN 0360-4012
McHugh, P., Joyce, P. and Kennedy, M. (2006) ‘The proteomics of antidepressant drug response’ American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics , 141B (7), pp. 787-788. ISSN 1552-4841
Joyce, P., McHugh, P., Kennedy, M., McKenzie, J., Sullivan, P., Mulder, R., Luty, S., Carter, J., Frampton, C., Robert Cloninger, C. and Miller, A. (2006) ‘A dopamine transporter polymorphism is a risk factor for borderline personality disorder in depressed patients’ Psychological Medicine , 36 (06), p. 807. ISSN 0033-2917
Harris, T., Gomas, K., Weir, F., Holyoake, A., McHugh, P., Wu, M., Sin, Y., Sin, I. and Sin, F. (2006) ‘Molecular analysis of polymerase gamma gene and mitochondrial polymorphism in fertile and subfertile men’ International Journal of Andrology , 29 (3), pp. 421-433. ISSN 0105-6263
Bland, M., McHugh, P., Joyce, P. and Kennedy, M. (2004) ‘Polymorphism analysis of serotonergic transcription factors’ American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics , 130B (1), p. 158. ISSN 1552-4841
McHugh, P., Rogers, G., Joyce, P. and Kennedy, M. (2004) ‘Embryonic stem cell-derived neurons : a model for antidepressant pharmacogenomics’ American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics , 130B (1), p. 158. ISSN 1552-4841
Armstrong, K., McHugh, P., Chinn, W., Frampton, E. and Walsh, P. (2003) ‘Tussock moth species arriving on imported used vehicles determined by DNA analysis ’ New Zealand Plant Protection , 56, pp. 16-20. ISSN 1175-9003
Holyoake, A., McHugh, P., Wu, M., O'Carroll, S., Benny, P., Sin, I. and Sin, F. (2002) ‘Research of single mitochondrial nucleotide substitutions in male infertility should consider human mitochondrial haplogroups - Reply’ International Journal of Andrology , 25 (6), pp. 374-374. ISSN 0105-6263
McHugh, P., Rogers, G., Cameron, V., Begg, E., Joyce, P. and Kennedy, M. (2002) ‘Pharmacogenomics of antidepressant drug responses’ American Journal of Medical Genetics. Part A , 114 (7), p. 881. ISSN 1552-4825
Holyoake, A., McHugh, P., Wu, M., O'Carroll, S., Benny, P., Sin, I. and Sin, F. (2001) ‘High incidence of single nucleotide substitutions in the mitochondrial genome is associated with poor semen parameters in men’ International Journal of Andrology , 24 (3), pp. 175-182. ISSN 0105-6263
Sin, F., Holyoake, A., McHugh, P., Wu, M., O'Carroll, S., Benny, P. and Sin, I. (2001) ‘High Frequencies of Nucleotide Substitutions in mtDNA in Subfertile Men ’. In: Andrology in the 21st Century : Proceedings of the VIIth International. : Medimond Medical . pp. 385-389. ISBN 9780970668011
Experience in techniques such as cell culture, PCR, cloning, QPCR, Western analysis, promoter assays, as well as a general knowledge of molecular biology would be an advantage to pursue post-graduate study in the above projects
If you are interested in working with Dr McHugh please e-mail your CV with a covering letter to email@example.com.