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Portrait of Dr Olumayokun Olajide Dr Olumayokun Olajide

o.a.olajide@hud.ac.uk | 01484 472735



Biography

Dr Olajide received his Ph.D. in Pharmacology from the University of Ibadan in Nigeria where he investigated anti-inflammatory properties of natural products. He was a Humboldt Postdoctoral Research Fellow at the Center for Drug Research (Pharmaceutical Biology), Department of Pharmacy, University of Munich, Germany where he studied cellular and molecular pharmacology of anti-inflammatory natural products, focusing on Nuclear Factor-kappa B (NF-κB) signalling. Part of his postdoctoral work was carried out in the Neurochemistry Research Laboratory, Department of Psychiatry, University of Freiburg Medical School where he conducted research on cellular and molecular pharmacology of anti-neuroinflammatory natural products.

Dr Olajide started his academic career as a Lecturer in Pharmacology in the Faculty of Pharmacy, Obafemi Awolowo University, Nigeria. He later moved to the College of Medicine, University of Ibadan, Nigeria as a Lecturer in Pharmacology. Dr Olajide had a brief stint in industry where he was involved in drug development and clinical research; he helped in developing new drugs for type 2 diabetes and atopic dermatitis. Prior to moving to Huddersfield, he was Senior Lecturer in Pharmaceutical Sciences at London Metropolitan University. Dr Olajide is on the editorial board of Evidence Based Complementary and Alternative Medicine (eCAM).

Research & Scholarship

Nuclear Factor-kappa B (NF-κB) Signalling in the Activated Microglia

Microglial NF-κB signalling pathway is critical to neuroinflammation as it is responsible for the transcriptional regulation of genes which contribute to damage and death of adjacent neurons in neurodegenerative disorders such as Alzheimer’s disease. Targeting NF-κB signalling in neuroinflammation is therefore an important strategy in identifying novel small molecules for delaying the onset and/or progression of diseases like AD. Research in my group investigates natural and novel synthetic compounds which inhibit neuroinflammation by targeting NF-κB and associated pathways involving the mitogen activated protein kinases (MAPKs) and PI3K/Akt.

Neuroprotection by Natural and Synthetic Steroids

Menopause is associated with sharp declines in the levels of circulating oestrogens. This hormonal change has been linked to impairment in brain functions relevant to dementia and cognitive aging. An accumulation of evidence suggests that oestrogens are neuroprotective. However, there are significant cancer risks associated with these hormones. Consequently, a promising translational tool could be the development of selective oestrogen receptor modulators (SERMs). In collaboration with medicinal chemists, we are currently employing structure-activity relationships to synthesise, optimise and investigate novel neuroprotective SERMs with much lower risks of cancer.

AMPK and Nrf2 Signalling in Neuroinflammation

Adenosine monophosphate-activated protein kinase (AMPK) is a critical sensor of cellular energy balance. However, new evidence shows that this kinase exhibits neuroprotective potentials. AMPK activation has been shown to cause marked inhibition on lipopolysaccharide (LPS)-mediated neuroinflammation in the microglia. Consequently, pharmacological activation of AMPK could be an important strategy in blocking the detrimental effects of neuroinflammation on neurons. The nuclear factor E2-related factor 2/heme oxygenase-1 (Nrf2/HO-1) antioxidant cytoprotective mechanism has been linked to AMPK signalling. Activation of Nrf2/HO-1 has also been shown to inhibit NF-κB, and ultimately neuroinflammation. Using pharmacological antagonists and RNA interference (RNAi), we are investigating the roles of AMPK/Nrf2 in anti-neuroinflammatory activity of selected compounds.

Neuroinflammation in Cerebral Malaria (CM)

Malaria is a wide spread infectious disease that is responsible for 2-3 million deaths annually. The most severe neurological complication of acute Plasmodium falciparum malaria is cerebral malaria (CM). In CM, the formation of a metabolic waste, hemozoin (HZ) has been shown to induce inflammation and morphological changes in microvascular endothelium, leading to an increase in blood brain barrier (BBB) permeability, neuroinflammation and neurological sequelae in survivors. Consequently, adjunctive therapies which target neuroinflammation are needed. We are currently investigating the impact of HZ on multiple signalling pathways in the microglia. We expect that this research will identify novel targets for discovering new drugs for adjunctive treatment of CM.

Publications and Other Research Outputs

2015

Velagapudi, R., Baco, G., Khela, S., Okorji , U. and Olajide, O. (2015) ‘Pomegranate inhibits neuroinflammation and amyloidogenesis in IL-1? stimulated SK-N-SH cells European Journal of Nutrition . ISSN 1436-6207

2014

Velagapudi, R., Aderogba, M. and Olajide, O. (2014) ‘Tiliroside, a dietary glycosidic flavonoid inhibits TRAF-6/NF-kB/p38-mediated neuroinflammation in activated BV2 microgliaBiochimica et Biophysica Acta (BBA) - General Subjects , 1840 (12), pp. 3311-3319. ISSN 03044165

Olajide, O., Kumar, A., Velagapudi, R., Okorji , U. and Fiebich, B. (2014) ‘Punicalagin inhibits neuroinflammation in LPS-activated rat primary microglia Molecular Nutrition and Food Research . ISSN 1613-4133

Okorji , U. and Olajide, O. (2014) ‘A semi-synthetic derivative of artemisinin, artesunate inhibits prostaglandin E2 production in LPS/IFN?-activated BV2 microgliaBioorganic and Medicinal Chemistry , 22 (17), pp. 4726-4734. ISSN 0968-0896

Velagapudi, R., Olajide, O. and Aderogba, M. (2014) ‘Tiliroside Produced Anti-Neuroinflammatory Effects Through Interference With NF-?B And MAPK Signalling In LPS+ IFN-? Stimulated BV-2 Microglia.pA2 Online . ISSN 1741-1149

Olajide, O., Velagapudi, R., Okorji , U., Sarker, S. and Fiebich, B. (2014) ‘Picralima nitida seeds suppress PGE2 production by interfering with multiple signalling pathways in IL 1?-stimulated SK-N-SH neuronal cellsJournal of ethnopharmacology , 152 (2), pp. 377-383. ISSN 0378-8741

Olajide, O. and Wright, C. (2014) ‘Cryptolepine induced apoptosis in TNFalpha-stimulated A549 lung carcinoma cells through NF-kappaB signalling pathwaypA2 Online . ISSN 1741-1149

Okorji , U. and Olajide, O. (2014) ‘Artesunate inhibits prostaglandin E2 (PGE2) production in LPS + IFN-? activated BV-2 microglia cellspA2 Online , 11 (3). ISSN 1741-1157

2013

Olajide, O. and Fiebich, B. (2013) ‘Traditional African Medicine as a source of biologically active substances inhibiting neuroinflammationPlanta Medica , 79 (13), p. 1112. ISSN 0032-0943

Olajide, O., Bhatia, H., de Oliveira, A., Wright, C. and Fiebich, B. (2013) ‘Inhibition of neuroinflammation in LPS-activated microglia by cryptolepine Evidence-Based Complementary and Alternative Medicine , 2013, pp. 1-10. ISSN 1741-427X

Olajide, O., Bhatia, H., Oliveira , A., Wright, C. and Fiebich, B. (2013) ‘Anti-neuroinflammatory properties of synthetic cryptolepine in human neuroblastoma cells: possible involvement of NF-kappaB and p38 MAPK inhibitionEuropean Journal of Medicinal Chemistry , 63, pp. 333-339. ISSN 0223-5234

Olajide, O., Aderogba, M. and Fiebich, B. (2013) ‘Mechanisms of Anti-inflammatory Property of Anacardium occidentale Stem Bark: Inhibition of NF-kappaB and MAPK Signaling in the MicrogliaJournal of ethnopharmacology , 145 (1), pp. 42-49. ISSN 0378-8741

Olajide, O. and Fiebich, B. (2013) ‘Pomegranate suppresses PGE2 production and COX- 2 expression in IL-1?-stimulated SK-N-SH neuronal cells: implications for Alzheimer’s disease.Planta Medica , 79, p. 1266. ISSN 0032-0943

2012

Olajide, O., Aderogba, M., Okorji , U. and Fiebich, B. (2012) ‘Bridelia ferruginea Produces Anti-neuroinflammatory Activity through Inhibition of Nuclear Factor-kappa B and p38 MAPK SignallingEvidence-Based Complementary and Alternative Medicine , 2012, pp. 1-8. ISSN 1741-427X

Olajide, O (2012) ‘Anti-neuroinflammatory and Anti-amyloidogenic Properties of Punicalagin in LPS-Activated Rat Primary Microglia’. In: BPS Winter Meeting, 18th - 20th December 2012, London, UK

2010

Olajide, O., Pinheiro de Oliveira, A., Unekwe, J., Wright, C. and Fiebich, B. (2010) ‘Cryptolepis sanguinolenta (Lindl.) Schltr. root extract inhibits prostaglandin production in IL-1b stimulated SK-N-SH neuronal cellsPlanta Medica , 76 (12), p. 601. ISSN 0032-0943

2009

Olajide, O., Ajayi, A. and Wright, C. (2009) ‘Anti-inflammatory properties of cryptolepine.Phytotherapy research , 23 (10), pp. 1421-1425. ISSN 1099-1573

Olajide, O (2009) ‘Inhibitory Effects of St. John's Wort on Inflammation: Ignored Potential of a Popular HerbJournal of Dietary Supplements , 6 (1), pp. 28-32. ISSN 1939-0211

2008

Awe, E., Adeloye, A., Idowu, T., Olajide, O. and Makinde, J. (2008) ‘Antinociceptive effect of Russelia equisetiformis leave extracts: Identification of its active constituents Phytomedicine , 15 (4), pp. 301-305. ISSN 0944-7113

Bhatia, H., Candelario-Jalil, E., de Oliveira, A., Olajide, O., Martínez-Sánchez, G. and Fiebich, B. (2008) ‘Mangiferin inhibits cyclooxygenase-2 expression and prostaglandin E2 production in activated rat microglial cells.Archives of biochemistry and biophysics , 477 (2), pp. 253-258. ISSN 1096-0384

2007

Olajide, O., Wright, C. and Fiebich, B. (2007) ‘Effects of Cryptolepis sanguinoleta root extract in lipopolysaccharide – stimulated human primary monocytesPlanta Medica , 73 (09), p. 077. ISSN 0032-0943

Olajide, O., Heiss, E., Schachner, D., Wright, C., Vollmar, A. and Dirsch, V. (2007) ‘Synthetic cryptolepine inhibits DNA binding of NF-kappaB.Bioorganic & medicinal chemistry , 15 (1), pp. 43-49. ISSN 0968-0896

2004

Olajide, O., Ogunleye, B. and Erinle, T. (2004) ‘Anti-inflammatory properties of Amaranthus Spinosus Leaf ExtractPharmaceutical Biology , 42 (7), pp. 521-525. ISSN 1388-0209

Awe, E., Makinde, J., Olajide, O. and Wakeel, O. (2004) ‘Evaluation of the anti-inflammatory and analgesic properties of the extract of Russelia equisetiformis (Schlecht & Cham) Scrophulariacae.Inflammopharmacology , 12 (4), pp. 399-405. ISSN 0925-4692

Olajide, O., Aderogba, M., Adedapo, A. and Makinde, J. (2004) ‘Effects of Anacardium occidentale stem bark extract on in vivo inflammatory models.Journal of ethnopharmacology , 95 (2-3), pp. 139-42. ISSN 0378-8741

Olajide, O., Echianu, C., Adedapo, A. and Makinde, J. (2004) ‘Anti-inflammatory studies on Adenanthera pavonina seed extract.Inflammopharmacology , 12 (2), pp. 196-202. ISSN 0925-4692

2003

Olajide, O., Okpako, D. and Makinde, J. (2003) ‘Anti-inflammatory properties of Bridelia ferruginea stem bark. Inhibition of lipopolysaccaride-induced septic shock and vascular permeability.Journal of ethnopharmacology , 88 (2-3), pp. 221-224. ISSN 0378-8741

Olajide, O., Makinde, J. and Okpako, D. (2003) ‘Evaluation of the anti-inflammatory property of the extract of Combretum micranthum G. Don (Combretaceae).Inflammopharmacology , 11 (3), pp. 293-298. ISSN 0925-4692

2002

Morebise, O., Fafunso, M., Makinde, J., Olajide, O. and Awe, E. (2002) ‘Antiinflammatory property of the leaves of Gongronema latifolium.Phytotherapy research : PTR , 16 (S1), pp. 75-77. ISSN 0951-418X

2001

Morebise, O., Awe, E., Makinde, J. and Olajide, O. (2001) ‘Evaluation of the anti-inflammatory and analgesic properties of Chasmanthera dependens leaf methanol extract.Fitoterapia , 72 (5), pp. 497-502. ISSN 0367-326X

Olajide, O. and Alada, A. (2001) ‘Studies on the anti-inflammatory properties of Entada abyssinica.Fitoterapia , 72 (5), pp. 492-496. ISSN 0367-326X

2000

Olajide, O., Makinde, J., Okpako, D. and Awe, S. (2000) ‘Studies on the anti-inflammatory and related pharmacological properties of the aqueous extract of Bridelia ferruginea stem bark.Journal of ethnopharmacology , 71 (1-2), pp. 153-60. ISSN 0378-8741

Olajide, O., Awe, S., Makinde, J., Ekhelar, A., Olusola, A., Morebise, O. and Okpako, D. (2000) ‘Studies on the anti-inflammatory, antipyretic and analgesic properties of Alstonia boonei stem bark.Journal of ethnopharmacology , 71 (1-2), pp. 179-186. ISSN 0378-8741

1999

Olajide, O., Awe, S., Makinde, J. and Morebise, O. (1999) ‘Evaluation of the anti-diabetic property of Morinda lucida leaves in streptozotocin-diabetic rats.The Journal of pharmacy and pharmacology , 51 (11), pp. 1321-1324. ISSN 0022-3573

Olajide, O., Makinde, J. and Awe, S. (1999) ‘Effects of the aqueous extract of Bridelia ferruginea stem bark on carrageenan-induced oedema and granuloma tissue formation in rats and mice.Journal of ethnopharmacology , 66 (1), pp. 113-117. ISSN 0378-8741

Olajide, O (1999) ‘Investigation of the effects of selected medicinal plants on experimental thrombosis.Phytotherapy research , 13 (3), pp. 231-2. ISSN 1099-1573

Research Degree Supervision

  1. Pharmacological inhibition of NF-B signalling in the activated microglia by novel compounds
  2. Neuroprotection by natural and synthetic Steroids
  3. Drugs and compounds which activate microglial and neuronal AMPK/Nrf2
  4. Neuroinflammation in cerebral malaria
Last updated Thursday 6 March 2014
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