Dr Lindsay Hardingl.p.harding@hud.ac.uk | 01484 472434
My research interests are in the area of analytical chemistry and I also run the School's NMR and mass spectrometry facilities. I have over 50 papers in various areas of analytical chemistry and collaborate with partners both across the UK and internationally.
I teach mass spectrometry, NMR and chromatography to second and final year undergraduates and am also the Second Year Tutor for Chemistry students.
My main research interests are in the synthesis and characterisation of novel coordination complexes.
Current projects include:
Bullock, S., Harding, L., Moore, M., Mills, A., Piela, S., Rice, C., Towns-Andrews, E. and Whitehead, M. (2013) ‘Synthesis of Ligands Containing N-oxide Donor Atoms and Their Assembly into Metallosupramolecular Structures.’ Dalton Transactions . ISSN 1477-9226
Bullock, S., Hallett, A., Harding, L., Higginson, J., Piela, S., Pope, S. and Rice, C. (2012) ‘Luminescent rhenium fac-tricarbonyl-containing complexes of androgenic oxo-steroids’ Dalton Transactions . ISSN 14779226
Ahmed, A., Harding, L. and Chrystyn, H. (2012) ‘Urinary pharmacokinetic methodology to determine the relative lung availability of inhaled beclometasone’ British Journal of Clinical Pharmacology , 74 (3), pp. 456-464. ISSN 1365-2125
Henkelis, J., Barnett, S., Harding, L. and Hardie, M. (2012) ‘Coordination polymers utilizing N-oxide functionalised host ligands’ Inorganic Chemistry , 51 (20), pp. 10657-10674. ISSN 0020-1669
Cox, N., Harding, L., Jones, J., Pope, S., Rice, C. and Adams, H. (2012) ‘Probing solution behaviour of metallosupramolecular complexes using pyrene fluorescence’ Dalton Transactions , 41 (5), pp. 1568-1573. ISSN 14779226
Sutton, C., Harding, L., Hardie, M., Riis-Johannessen, T. and Rice, C. (2012) ‘Allosteric Effects in a Ditopic Ligand Containing Bipyridine and Tetra-aza-crown Donor Units’ Chemistry - A European Journal , 18 (12), pp. 3464-3467. ISSN 0947-6539
Henkelis, J., Ronson, T., Harding, L. and Hardie, M. (2011) ‘M3L2 metallo-cryptophanes: [2]catenane and simple cages’ Chemical Communications , 47 (23), pp. 6560-6562. ISSN 13597345
Clegg, O., Fennessy, R., Harding, L., Rice, C., Riis-Johannessen, T. and Fletcher, N. (2011) ‘Diastereoselective assembly of pentanuclear circular helicates’ Dalton Transactions , 40 (45), pp. 12381-12387. ISSN 1477-9226
Little, M., Halcrow, M., Harding, L. and Hardie, M. (2010) ‘Ag(I) organometallic coordination polymers and capsule with tris-allyl cyclotriveratrylene derivatives’ Inorganic Chemistry , 49 (20), pp. 9486-9496. ISSN 00201669
Allen, K., Faulkner, R., Harding, L., Rice, C., Riis-Johannessen, T., Voss, M. and Whitehead, M. (2010) ‘Head-To-Tail and Heteroleptic Pentanuclear Circular Helicates’ Angewandte Chemie International Edition , 49 (37), pp. 6655-6658. ISSN 1433-7851
Bain, L., Bullock, S., Harding, L., Riis-Johannessen, T., Midgley, G., Rice, C. and Whitehead, M. (2010) ‘Controlling the formation of metallosupramolecular assemblies by metal ionic radii’ Chemical Communications , 46 (20), pp. 3496-3498. ISSN 1359-7345
Andrews, M., Jones, J., Harding, L. and Pope, S. (2010) ‘Luminescent probes based on water-soluble, dual-emissive lanthanide complexes: metal ion-induced modulation of near-IR emission’ Chemical Communications . ISSN 1359-7345
Andrews, M., Amoroso, A., Harding, L. and Pope, S. (2010) ‘Responsive, di-metallic lanthanide complexes of a piperazine-bridged bis-macrocyclic ligand: modulation of visible luminescence and proton relaxivity’ Dalton Transactions , 39 (14), pp. 3407-3411. ISSN 14779226
Ronson, T., Carruthers, C., Fisher, J., Brotin, T., Harding, L., Rizkallah, P. and Hardie, M. (2010) ‘Tripodal 4-Pyridyl-Derived Host Ligands and Their Metallo-Supramolecular Chemistry: Stella Octangula and Bowl-Shaped Assemblies’ Inorganic Chemistry , 49 (2), pp. 675-685. ISSN 00201669
Carruthers, C., Fisher, J., Harding, L. and Hardie, M. (2010) ‘Host–guest influence on metallo-supramolecular assemblies with a cyclotriveratrylene-type ligand’ Dalton Transactions , 39 (2), pp. 355-357. ISSN 14779226
Bullock, S., Felton, C., Fennessy, R., Harding, L., Andrews, M., Pope, S., Rice, C. and Riis-Johannessen, T. (2009) ‘Coumarin-based luminescent ligand that forms helicates with dicationic metal ions’ Dalton Transactions , 47, pp. 10570-10573. ISSN 14779226
Lu, J., Turner, D., Harding, L. and Batten, S. (2009) ‘Heteroligand Molecular “Stirrups” Using Conformationally Flexible Ditopic Pyridyl?Pyrazolyl Ligands’ Inorganic Chemistry , 48 (16), pp. 7525-7527. ISSN 00201669
Lu, J., Turner, D., Harding, L., Byrne, L., Baker, M. and Batten, S. (2009) ‘Octapi Interactions: Self-Assembly of a Pd-Based [2]Catenane Driven by Eightfold ? Interactions’ Journal of the American Chemical Society , 131 (30), pp. 10372-10373. ISSN 1520-5126
Bullock, S., Gillie, L., Harding, L., Rice, C., Riis-Johannessen, T. and Whitehead, M. (2009) ‘Isomeric pyridyl-thiazole donor units for metal ion recognition in bi- and tri-metallic helicates’ Chemical Communications (32), pp. 4856-4858. ISSN 1359-7345
Ronson, T., Fisher, J., Harding, L., Rizkallah, P., Warren, J. and Hardie, M. (2009) ‘Stellated polyhedral assembly of a topologically complicated Pd4L4 ‘Solomon cube’’ Nature Chemistry , 1 (3), pp. 212-216. ISSN 17554330
Felton, C., Harding, L., Jones, J., Kariuki, B., Pope, S. and Rice, C. (2008) ‘A wavelength and lifetime responsive cryptate-containing fluorescent probe for zinc ions in water’ Chemical Communications (46), pp. 6185-6187. ISSN 1359-7345
Carruthers, C., Ronson, T., Sumby, C., Westcott, A., Harding, L., Prior, T., Rizkallah, P. and Hardie, M. (2008) ‘The Dimeric “Hand-Shake” Motif in Complexes and Metallo-Supramolecular Assemblies of Cyclotriveratrylene-Based Ligands’ Chemistry - A European Journal , 14 (33), pp. 10286-10296. ISSN 09476539
Tidmarsh, I., Faust, T., Adams, H., Harding, L., Russo, L., Clegg, W. and Ward, M. (2008) ‘Octanuclear Cubic Coordination Cages’ Journal of the American Chemical Society , 130 (45), pp. 15167-15175. ISSN 1520-5126
Andrews, M., Laye, R., Harding, L. and Pope, S. (2008) ‘Quinoxaline sensitised lanthanide ion luminescence: Syntheses, spectroscopy and X-ray crystal structure of Na{1,4,7-tris[(N-diethyl)carbamoylmethyl]-1,4,7,10-tetraazacyclododecane-10-(2-methylquinoxaline)}I3 C7H8’ Polyhedron , 27 (11), pp. 2365-2371. ISSN 02775387
Al-Rasbi, N., Tidmarsh, I., Argent, S., Adams, H., Harding, L. and Ward, M. (2008) ‘Mixed-Ligand Molecular Paneling: Dodecanuclear Cuboctahedral Coordination Cages Based on a Combination of Edge-Bridging and Face-Capping Ligands’ Journal of the American Chemical Society , 130 (35), pp. 11641-11649. ISSN 1520-5126
Westcott, A., Fisher, J., Harding, L., Rizkallah, P. and Hardie, M. (2008) ‘Self-Assembly of a 3-D Triply Interlocked Chiral [2]Catenane’ Journal of the American Chemical Society , 130 (10), pp. 2950-2951. ISSN 1520-5126
Westcott, A., Fisher, J., Harding, L. and Hardie, M. (2008) ‘Flattened trigonal bipyramidal coordination assembly with trans geometry’ CrystEngComm , 10 (3), pp. 276-278. ISSN 1466-8033
Clayton, H., Harding, L., Irvine, J., Jeffery, J., Riis-Johannessen, T., Laws, A., Rice, C. and Whitehead, M. (2008) ‘Metal-specific allosteric activation and deactivation of a diamine’ Chemical Communications (1), p. 108. ISSN 1364-548X
Mullice, L., Laye, R., Harding, L. and Buurma, N. (2008) ‘Rhenium complexes of chromophore-appended dipicolylamine ligands: syntheses, spectroscopic properties, DNA binding and X-ray crystal structure’ New Journal of Chemistry , 32 (12), pp. 2140-2149. ISSN 1144-0546
Ronson, T., Fisher, J., Harding, L. and Hardie, M. (2007) ‘Star-Burst Prisms with Cyclotriveratrylene-Type Ligands: A [Pd6L8]12+ Stella Octangular Structure’ Angewandte Chemie International Edition , 46 (47), pp. 9086-9088. ISSN 14337851
Riis-Johannessen, T., Harding, L., Jeffery, J., Moon, R. and Rice, C. (2007) ‘Allosteric deprogramming of a trinuclear heterometallic helicate’ Dalton Transactions (16), pp. 1577-1587. ISSN 14779226
Ronson, T., Adams, H., Harding, L., Pope, S., Sykes, D., Faulkner, S. and Ward, M. (2007) ‘Polynuclear lanthanide complexes of a series of bridging ligands containing two tridentate N,N?,O-donor units: structures and luminescence properties’ Dalton Transactions (10), pp. 1006-1022. ISSN 14779226
Al-Rasbi, N., Adams, H., Harding, L. and Ward, M. (2007) ‘Coordination Behaviour of Bis-Terdentate N-Donor Ligands: Double- and single-stranded helicates, mesocates, and cyclic oligomers ’ European Journal of Inorganic Chemistry , 2007 (30), pp. 4770-4780. ISSN 1434-1948
Ronson, T., Adams, H., Harding, L., Harrington, R., Clegg, W. and Ward, M. (2007) ‘Synthesis and structures of cadmium(II) complexes of a series of multinucleating N/S donor ligands’ Polyhedron , 26 (12), pp. 2777-2785. ISSN 02775387
Jeffery, J., Rice, C., Harding, L., Baylies, C. and Riis-Johannessen, T. (2007) ‘Ligand Reprogramming in Dinuclear Helicate Complexes: A Consequence of Allosteric or Electrostatic Effects?’ Chemistry - A European Journal , 13 (18), pp. 5256-5271. ISSN 09476539
Baylies, C., Harding, L., Jeffery, J., Moon, R., Rice, C. and Riis-Johannessen, T. (2007) ‘Electrostatic control of the formation of heteroleptic transition metal helicates’ New Journal of Chemistry , 31 (8), pp. 1525-1529. ISSN 11440546
Argent, S., Adams, H., Riis-Johannessen, T., Jeffery, J., Harding, L., Mamula, O. and Ward, M. (2006) ‘Coordination Chemistry of Tetradentate N-Donor Ligands Containing Two Pyrazolyl-Pyridine Units Separated by a 1,8-Naphthyl Spacer: Dodecanuclear and Tetranuclear Coordination Cages and Cyclic Helicates’ Inorganic Chemistry , 45 (10), pp. 3905-3919. ISSN 0020-1669
Coldwell, J., Felton, C., Harding, L., Moon, R., Pope, S. and Rice, C. (2006) ‘Barium induced modulation of NIR emission in a neodymium cryptate complex’ Chemical Communications , 2006, pp. 5048-5050. ISSN 1364-548X
Argent, S., Adams, H., Harding, L. and Ward, M. (2006) ‘A closed molecular cube and an open book: two different products from assembly of the same metal salt and bridging ligand ’ Dalton Transactions , 2006 (4), pp. 542-544. ISSN 1477-9226
Argent, S., Adams, H., Riis-Johannessen, T., Jeffery, J., Harding, L., Clegg, W., Harrington, R. and Ward, M. (2006) ‘Complexes of Ag(I), Hg(I) and Hg(II) with multidentate pyrazolyl-pyridine ligands: from mononuclear complexes to coordination polymers via helicates, a mesocate, a cage and a catenate’ Dalton Transactions , 2006 (42), pp. 4996-5013. ISSN 1477-9226
Bokolinis, G., Riis-Johannessen, T., Harding, L., Jeffery, J., McLay, N. and Rice, C. (2006) ‘This facile interconversion of dinuclear double helicates and side-by-side species: a reprogrammable ligand with potential sensor applications ’ Chemical Communications , pp. 1980-1982. ISSN 1364-548X
Argent, S., Adams, H., Riis-Johannessen, T., Jeffery, J., Harding, L. and Ward, M. (2005) ‘High-nuclearity homoleptic and heteroleptic coordination cages based on tetra-capped truncated tetrahedral and cuboctahedral metal frameworks ’ Journal of the American Chemical Society , 128 (1), pp. 72-73. ISSN 1520-5126
Riis-Johannessen, T., Jeffery, J., Robson, A., Rice, C. and Harding, L. (2005) ‘Solution and solid-state complexes of the potentially tetradentate pyridyl-thiazole ligand 6,6?-bis(4-methylthiazol-2-yl)-2,2?-bipyridine with Co, Ni, Cu, Cd, Hg, Cu and Ag’ Inorganica Chimica Acta , 358 (9), pp. 2781-2798. ISSN 0020-1693
Argent, S., Adams, H., Harding, L., Riis-Johannessen, T., Jeffery, J. and Ward, M. (2005) ‘Homo- and heteropolynuclear helicates with a ‘2 + 3 + 2’-dentate compartmental ligand’ New Journal of Chemistry , 29 (7), pp. 904-911. ISSN 1144-0546
Argent, S., Riis-Johannessen, T., Jeffery, J., Harding, L. and Ward, M. (2005) ‘Diastereoselective formation and optical activity of an M4L6 cage complex’ Chemical Communications (37), pp. 4647-4649. ISSN 1359-7345
Harding, L., Marshall, V., Hernandez, Y., Gu, Y., Maqsood, M., McLay, N. and Laws, A. (2005) ‘Structural characterisation of the highly branched exopolysaccharide produced by Lactobacillus delbrueckii subsp. Bulgaricus NCFB2074’ Carbohydrate Research , 340 (6), pp. 1107-1111. ISSN 0008-6215
Tsang, W., Ahmed, N., Hinchliffe, P., Wood, J., Harding, L., Laws, A. and Page, M. (2005) ‘Different transition-state structures for the reactions of ?-lactams and analogous ?-sultams with serine ?-lactamases ’ Journal of the American Chemical Society , 127 (49), pp. 17556-17564. ISSN 1520-5126
Tsang, W., Ahmed, N., Harding, L., Hemming, K., Laws, A. and Page, M. (2005) ‘Acylation versus sulfonylation in the inhibition of elastase by 3-oxo-beta-sultams ’ Journal of the American Chemical Society , 127 (25), pp. 8946-8947. ISSN 1520-5126
Baylies, C., Riis-Johannessen, T., Harding, L., Jeffery, J., Moon, R., Rice, C. and Whitehead, M. (2005) ‘Allosteric-Controlled Metal Specificity of a Ditopic Ligand’ Angewandte Chemie International Edition , 44 (42), pp. 6909-6912. ISSN 1433-7851
Baylies, C., Harding, L., Jeffery, J., Riis-Johannessen, T. and Rice, C. (2004) ‘Allosteric and electrostatic reprogramming of a ditopic ligand’ Angewandte Chemie International Edition , 43 (34), pp. 4515-4518. ISSN 14337851
Harding, L., Jeffery, J., Riis-Johannessen, T., Rice, C. and Zeng, Z. (2004) ‘Anion control of the formation of geometric isomers in a triple helical array ’ Dalton Transactions (16), pp. 2396-2397. ISSN 14779226
Paul, R., Argent, S., Jeffery, J., Harding, L., Lynam, J. and Ward, M. (2004) ‘Structures and anion-binding properties of M4L6 tetrahedral cage complexes with large central cavities’ Dalton Transactions (21), pp. 3453-3458. ISSN 14779226
Harding, L., Jeffery, J., Riis-Johannessen, T., Rice, C. and Zeng, Z. (2004) ‘Anion control of ligand self-recognition in a triple helical array ’ Chemical Communications (6), pp. 654-655. ISSN 1364-548X
Page, M., Hinchliffe, P., Wood, J., Harding, L. and Laws, A. (2003) ‘Novel mechanism of inhibiting b-lactamases by sulfonylation using b-sultams ’ Bioorganic & Medicinal Chemistry Letters , 13 (24), pp. 4489-4492. ISSN 0960-894X
Paul, R., Bell, Z., Jeffery, J., Harding, L., McCleverty, J. and Ward, M. (2003) ‘Complexes of a bis-bidentate ligand with d10 ions: a mononuclear complex with Ag(I), and a tetrahedral cage complex with Zn(II) which encapsulates a fluoroborate anion’ Polyhedron , 22 (5), pp. 781-787. ISSN 02775387
Rice, C., Baylies, C., Harding, L., Jeffery, J., Paul, R. and Ward`, M. (2003) ‘Cadmium-containing pyridyl–thiazole complexes: crystal structures and solution behaviour of mononuclear, dinuclear double helicate and dinuclear triple helicate complexes’ Polyhedron , 22 (5), pp. 755-762. ISSN 02775387
Harding, L., Marshall, V., Elvin, M., Gu, Y. and Laws, A. (2003) ‘Structural characterisation of a perdeuteriomethylated exoploysaccharide by NMR spectroscopy: characterisation of the novel exopolysaccharide produced by Lactobacillus delbrueckii subsp. Bulgaricus EU23’ Carbohydrate Research , 338 (1), pp. 61-67. ISSN 0008-6215
Bell, Z., Harding, L. and Ward, M. (2003) ‘Self-assembly of a molecular M8L12 cube having S6 symmetryElectronic supplementary information (ESI) available: Fig. S1 and S2. See http://www.rsc.org/suppdata/cc/b3/b307172n/’ Chemical Communications (19), pp. 2432-2433. ISSN 1359-7345
Rice, C., Baylies, C., Harding, L., Jeffery, J. and Paul, R. (2001) ‘Pyridyl-thiazole multidentate ligands: metal-specific recognition of a combination of ligands from a mixture’ Journal of the Chemical Society Dalton Transactions (20), pp. 3039-3044. ISSN 1472-7773
I currently have two PhD students and a placement student working in my group.
