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Portrait of Dr Lindsay Harding Dr Lindsay Harding

l.p.harding@hud.ac.uk | 01484 472434



Biography

My research interests are in the area of analytical chemistry and I also run the School's NMR and mass spectrometry facilities. I have over 50 papers in various areas of analytical chemistry and collaborate with partners both across the UK and internationally.

I teach mass spectrometry, NMR and chromatography to second and final year undergraduates and am also the Second Year Tutor for Chemistry students.

Research & Scholarship

My main research interests are in the synthesis and characterisation of novel coordination complexes.

Current projects include:

  • Synthesis of novel coordination complexes incorporating molecules of biological interest
  • Use of chemoenzymatic synthesis to prepare building blocks for coordination complexes
  • Characterisation of metallosupramolecular species in the solution state

Publications and Other Research Outputs

2013

Clegg, O., Harding, L., Miller, J. and Rice, C. (2013) ‘Tricarbonylchlorido(6'7'-dihydro-5’H-spiro[cyclopentane-1,6'-dipyrido-[3,2-d:2',3'-f][1,3]diazepine]-?2N1,N11)-rhenium(I)Acta Crystallographica Section E , 69 (10), p. m526. ISSN 1600-5368

Cooke, D., Cross, J., Fennessy, R., Harding, L., Rice, C. and Slater, C. (2013) ‘Steric control of the formation of dinuclear double helicate and dinuclear meso-helicate assembliesChemical Communications , 49 (71), pp. 7785-7787. ISSN 1359-7345

Bullock, S., Harding, L., Moore, M., Mills, A., Piela, S., Rice, C., Towns-Andrews, E. and Whitehead, M. (2013) ‘Synthesis of Ligands Containing N-oxide Donor Atoms and Their Assembly into Metallosupramolecular Structures.Dalton Transactions . ISSN 1477-9226

2012

Bullock, S., Hallett, A., Harding, L., Higginson, J., Piela, S., Pope, S. and Rice, C. (2012) ‘Luminescent rhenium fac-tricarbonyl-containing complexes of androgenic oxo-steroidsDalton Transactions . ISSN 14779226

Ahmed, A., Harding, L. and Chrystyn, H. (2012) ‘Urinary pharmacokinetic methodology to determine the relative lung availability of inhaled beclometasoneBritish Journal of Clinical Pharmacology , 74 (3), pp. 456-464. ISSN 1365-2125

Henkelis, J., Barnett, S., Harding, L. and Hardie, M. (2012) ‘Coordination polymers utilizing N-oxide functionalised host ligandsInorganic Chemistry , 51 (20), pp. 10657-10674. ISSN 0020-1669

Cox, N., Harding, L., Jones, J., Pope, S., Rice, C. and Adams, H. (2012) ‘Probing solution behaviour of metallosupramolecular complexes using pyrene fluorescenceDalton Transactions , 41 (5), pp. 1568-1573. ISSN 14779226

Sutton, C., Harding, L., Hardie, M., Riis-Johannessen, T. and Rice, C. (2012) ‘Allosteric Effects in a Ditopic Ligand Containing Bipyridine and Tetra-aza-crown Donor UnitsChemistry - A European Journal , 18 (12), pp. 3464-3467. ISSN 0947-6539

2011

Henkelis, J., Ronson, T., Harding, L. and Hardie, M. (2011) ‘M3L2 metallo-cryptophanes: [2]catenane and simple cagesChemical Communications , 47 (23), pp. 6560-6562. ISSN 13597345

Clegg, O., Fennessy, R., Harding, L., Rice, C., Riis-Johannessen, T. and Fletcher, N. (2011) ‘Diastereoselective assembly of pentanuclear circular helicatesDalton Transactions , 40 (45), pp. 12381-12387. ISSN 1477-9226

2010

Little, M., Halcrow, M., Harding, L. and Hardie, M. (2010) ‘Ag(I) organometallic coordination polymers and capsule with tris-allyl cyclotriveratrylene derivativesInorganic Chemistry , 49 (20), pp. 9486-9496. ISSN 00201669

Allen, K., Faulkner, R., Harding, L., Rice, C., Riis-Johannessen, T., Voss, M. and Whitehead, M. (2010) ‘Head-To-Tail and Heteroleptic Pentanuclear Circular HelicatesAngewandte Chemie International Edition , 49 (37), pp. 6655-6658. ISSN 1433-7851

Bain, L., Bullock, S., Harding, L., Riis-Johannessen, T., Midgley, G., Rice, C. and Whitehead, M. (2010) ‘Controlling the formation of metallosupramolecular assemblies by metal ionic radiiChemical Communications , 46 (20), pp. 3496-3498. ISSN 1359-7345

Andrews, M., Jones, J., Harding, L. and Pope, S. (2010) ‘Luminescent probes based on water-soluble, dual-emissive lanthanide complexes: metal ion-induced modulation of near-IR emissionChemical Communications . ISSN 1359-7345

Andrews, M., Amoroso, A., Harding, L. and Pope, S. (2010) ‘Responsive, di-metallic lanthanide complexes of a piperazine-bridged bis-macrocyclic ligand: modulation of visible luminescence and proton relaxivityDalton Transactions , 39 (14), pp. 3407-3411. ISSN 14779226

Ronson, T., Carruthers, C., Fisher, J., Brotin, T., Harding, L., Rizkallah, P. and Hardie, M. (2010) ‘Tripodal 4-Pyridyl-Derived Host Ligands and Their Metallo-Supramolecular Chemistry: Stella Octangula and Bowl-Shaped AssembliesInorganic Chemistry , 49 (2), pp. 675-685. ISSN 00201669

Carruthers, C., Fisher, J., Harding, L. and Hardie, M. (2010) ‘Host–guest influence on metallo-supramolecular assemblies with a cyclotriveratrylene-type ligandDalton Transactions , 39 (2), pp. 355-357. ISSN 14779226

2009

Bullock, S., Felton, C., Fennessy, R., Harding, L., Andrews, M., Pope, S., Rice, C. and Riis-Johannessen, T. (2009) ‘Coumarin-based luminescent ligand that forms helicates with dicationic metal ionsDalton Transactions , 47, pp. 10570-10573. ISSN 14779226

Lu, J., Turner, D., Harding, L. and Batten, S. (2009) ‘Heteroligand Molecular “Stirrups” Using Conformationally Flexible Ditopic Pyridyl?Pyrazolyl LigandsInorganic Chemistry , 48 (16), pp. 7525-7527. ISSN 00201669

Lu, J., Turner, D., Harding, L., Byrne, L., Baker, M. and Batten, S. (2009) ‘Octapi Interactions: Self-Assembly of a Pd-Based [2]Catenane Driven by Eightfold ? InteractionsJournal of the American Chemical Society , 131 (30), pp. 10372-10373. ISSN 1520-5126

Bullock, S., Gillie, L., Harding, L., Rice, C., Riis-Johannessen, T. and Whitehead, M. (2009) ‘Isomeric pyridyl-thiazole donor units for metal ion recognition in bi- and tri-metallic helicatesChemical Communications , 2009 (32), pp. 4856-4858. ISSN 1359-7345

Ronson, T., Fisher, J., Harding, L., Rizkallah, P., Warren, J. and Hardie, M. (2009) ‘Stellated polyhedral assembly of a topologically complicated Pd4L4 ‘Solomon cube’Nature Chemistry , 1 (3), pp. 212-216. ISSN 17554330

2008

Felton, C., Harding, L., Jones, J., Kariuki, B., Pope, S. and Rice, C. (2008) ‘A wavelength and lifetime responsive cryptate-containing fluorescent probe for zinc ions in waterChemical Communications (46), pp. 6185-6187. ISSN 1359-7345

Carruthers, C., Ronson, T., Sumby, C., Westcott, A., Harding, L., Prior, T., Rizkallah, P. and Hardie, M. (2008) ‘The Dimeric “Hand-Shake” Motif in Complexes and Metallo-Supramolecular Assemblies of Cyclotriveratrylene-Based LigandsChemistry - A European Journal , 14 (33), pp. 10286-10296. ISSN 09476539

Tidmarsh, I., Faust, T., Adams, H., Harding, L., Russo, L., Clegg, W. and Ward, M. (2008) ‘Octanuclear Cubic Coordination CagesJournal of the American Chemical Society , 130 (45), pp. 15167-15175. ISSN 1520-5126

Andrews, M., Laye, R., Harding, L. and Pope, S. (2008) ‘Quinoxaline sensitised lanthanide ion luminescence: Syntheses, spectroscopy and X-ray crystal structure of Na{1,4,7-tris[(N-diethyl)carbamoylmethyl]-1,4,7,10-tetraazacyclododecane-10-(2-methylquinoxaline)}I3 C7H8Polyhedron , 27 (11), pp. 2365-2371. ISSN 02775387

Al-Rasbi, N., Tidmarsh, I., Argent, S., Adams, H., Harding, L. and Ward, M. (2008) ‘Mixed-Ligand Molecular Paneling: Dodecanuclear Cuboctahedral Coordination Cages Based on a Combination of Edge-Bridging and Face-Capping LigandsJournal of the American Chemical Society , 130 (35), pp. 11641-11649. ISSN 1520-5126

Westcott, A., Fisher, J., Harding, L., Rizkallah, P. and Hardie, M. (2008) ‘Self-Assembly of a 3-D Triply Interlocked Chiral [2]CatenaneJournal of the American Chemical Society , 130 (10), pp. 2950-2951. ISSN 1520-5126

Westcott, A., Fisher, J., Harding, L. and Hardie, M. (2008) ‘Flattened trigonal bipyramidal coordination assembly with trans geometryCrystEngComm , 10 (3), pp. 276-278. ISSN 1466-8033

Clayton, H., Harding, L., Irvine, J., Jeffery, J., Riis-Johannessen, T., Laws, A., Rice, C. and Whitehead, M. (2008) ‘Metal-specific allosteric activation and deactivation of a diamineChemical Communications (1), p. 108. ISSN 1364-548X

Mullice, L., Laye, R., Harding, L. and Buurma, N. (2008) ‘Rhenium complexes of chromophore-appended dipicolylamine ligands: syntheses, spectroscopic properties, DNA binding and X-ray crystal structureNew Journal of Chemistry , 32 (12), pp. 2140-2149. ISSN 1144-0546

2007

Ronson, T., Fisher, J., Harding, L. and Hardie, M. (2007) ‘Star-Burst Prisms with Cyclotriveratrylene-Type Ligands: A [Pd6L8]12+ Stella Octangular StructureAngewandte Chemie International Edition , 46 (47), pp. 9086-9088. ISSN 14337851

Riis-Johannessen, T., Harding, L., Jeffery, J., Moon, R. and Rice, C. (2007) ‘Allosteric deprogramming of a trinuclear heterometallic helicateDalton Transactions (16), pp. 1577-1587. ISSN 14779226

Ronson, T., Adams, H., Harding, L., Pope, S., Sykes, D., Faulkner, S. and Ward, M. (2007) ‘Polynuclear lanthanide complexes of a series of bridging ligands containing two tridentate N,N?,O-donor units: structures and luminescence propertiesDalton Transactions (10), pp. 1006-1022. ISSN 14779226

Al-Rasbi, N., Adams, H., Harding, L. and Ward, M. (2007) ‘Coordination Behaviour of Bis-Terdentate N-Donor Ligands: Double- and single-stranded helicates, mesocates, and cyclic oligomers European Journal of Inorganic Chemistry , 2007 (30), pp. 4770-4780. ISSN 1434-1948

Ronson, T., Adams, H., Harding, L., Harrington, R., Clegg, W. and Ward, M. (2007) ‘Synthesis and structures of cadmium(II) complexes of a series of multinucleating N/S donor ligandsPolyhedron , 26 (12), pp. 2777-2785. ISSN 02775387

Jeffery, J., Rice, C., Harding, L., Baylies, C. and Riis-Johannessen, T. (2007) ‘Ligand Reprogramming in Dinuclear Helicate Complexes: A Consequence of Allosteric or Electrostatic Effects?Chemistry - A European Journal , 13 (18), pp. 5256-5271. ISSN 09476539

Baylies, C., Harding, L., Jeffery, J., Moon, R., Rice, C. and Riis-Johannessen, T. (2007) ‘Electrostatic control of the formation of heteroleptic transition metal helicatesNew Journal of Chemistry , 31 (8), pp. 1525-1529. ISSN 11440546

2006

Argent, S., Adams, H., Riis-Johannessen, T., Jeffery, J., Harding, L., Mamula, O. and Ward, M. (2006) ‘Coordination Chemistry of Tetradentate N-Donor Ligands Containing Two Pyrazolyl-Pyridine Units Separated by a 1,8-Naphthyl Spacer: Dodecanuclear and Tetranuclear Coordination Cages and Cyclic HelicatesInorganic Chemistry , 45 (10), pp. 3905-3919. ISSN 0020-1669

Coldwell, J., Felton, C., Harding, L., Moon, R., Pope, S. and Rice, C. (2006) ‘Barium induced modulation of NIR emission in a neodymium cryptate complexChemical Communications , 2006, pp. 5048-5050. ISSN 1364-548X

Argent, S., Adams, H., Harding, L. and Ward, M. (2006) ‘A closed molecular cube and an open book: two different products from assembly of the same metal salt and bridging ligand Dalton Transactions , 2006 (4), pp. 542-544. ISSN 1477-9226

Argent, S., Adams, H., Riis-Johannessen, T., Jeffery, J., Harding, L., Clegg, W., Harrington, R. and Ward, M. (2006) ‘Complexes of Ag(I), Hg(I) and Hg(II) with multidentate pyrazolyl-pyridine ligands: from mononuclear complexes to coordination polymers via helicates, a mesocate, a cage and a catenateDalton Transactions , 2006 (42), pp. 4996-5013. ISSN 1477-9226

Bokolinis, G., Riis-Johannessen, T., Harding, L., Jeffery, J., McLay, N. and Rice, C. (2006) ‘This facile interconversion of dinuclear double helicates and side-by-side species: a reprogrammable ligand with potential sensor applications Chemical Communications , pp. 1980-1982. ISSN 1364-548X

2005

Argent, S., Adams, H., Riis-Johannessen, T., Jeffery, J., Harding, L. and Ward, M. (2005) ‘High-nuclearity homoleptic and heteroleptic coordination cages based on tetra-capped truncated tetrahedral and cuboctahedral metal frameworks Journal of the American Chemical Society , 128 (1), pp. 72-73. ISSN 1520-5126

Riis-Johannessen, T., Jeffery, J., Robson, A., Rice, C. and Harding, L. (2005) ‘Solution and solid-state complexes of the potentially tetradentate pyridyl-thiazole ligand 6,6?-bis(4-methylthiazol-2-yl)-2,2?-bipyridine with Co, Ni, Cu, Cd, Hg, Cu and AgInorganica Chimica Acta , 358 (9), pp. 2781-2798. ISSN 0020-1693

Argent, S., Adams, H., Harding, L., Riis-Johannessen, T., Jeffery, J. and Ward, M. (2005) ‘Homo- and heteropolynuclear helicates with a ‘2 + 3 + 2’-dentate compartmental ligandNew Journal of Chemistry , 29 (7), pp. 904-911. ISSN 1144-0546

Argent, S., Riis-Johannessen, T., Jeffery, J., Harding, L. and Ward, M. (2005) ‘Diastereoselective formation and optical activity of an M4L6 cage complexChemical Communications (37), pp. 4647-4649. ISSN 1359-7345

Harding, L., Marshall, V., Hernandez, Y., Gu, Y., Maqsood, M., McLay, N. and Laws, A. (2005) ‘Structural characterisation of the highly branched exopolysaccharide produced by Lactobacillus delbrueckii subsp. Bulgaricus NCFB2074Carbohydrate Research , 340 (6), pp. 1107-1111. ISSN 0008-6215

Tsang, W., Ahmed, N., Hinchliffe, P., Wood, J., Harding, L., Laws, A. and Page, M. (2005) ‘Different transition-state structures for the reactions of ?-lactams and analogous ?-sultams with serine ?-lactamases Journal of the American Chemical Society , 127 (49), pp. 17556-17564. ISSN 1520-5126

Tsang, W., Ahmed, N., Harding, L., Hemming, K., Laws, A. and Page, M. (2005) ‘Acylation versus sulfonylation in the inhibition of elastase by 3-oxo-beta-sultams Journal of the American Chemical Society , 127 (25), pp. 8946-8947. ISSN 1520-5126

Baylies, C., Riis-Johannessen, T., Harding, L., Jeffery, J., Moon, R., Rice, C. and Whitehead, M. (2005) ‘Allosteric-Controlled Metal Specificity of a Ditopic LigandAngewandte Chemie International Edition , 44 (42), pp. 6909-6912. ISSN 1433-7851

2004

Baylies, C., Harding, L., Jeffery, J., Riis-Johannessen, T. and Rice, C. (2004) ‘Allosteric and electrostatic reprogramming of a ditopic ligandAngewandte Chemie International Edition , 43 (34), pp. 4515-4518. ISSN 14337851

Harding, L., Jeffery, J., Riis-Johannessen, T., Rice, C. and Zeng, Z. (2004) ‘Anion control of the formation of geometric isomers in a triple helical array Dalton Transactions (16), pp. 2396-2397. ISSN 14779226

Paul, R., Argent, S., Jeffery, J., Harding, L., Lynam, J. and Ward, M. (2004) ‘Structures and anion-binding properties of M4L6 tetrahedral cage complexes with large central cavitiesDalton Transactions (21), pp. 3453-3458. ISSN 14779226

Harding, L., Jeffery, J., Riis-Johannessen, T., Rice, C. and Zeng, Z. (2004) ‘Anion control of ligand self-recognition in a triple helical array Chemical Communications (6), pp. 654-655. ISSN 1364-548X

2003

Page, M., Hinchliffe, P., Wood, J., Harding, L. and Laws, A. (2003) ‘Novel mechanism of inhibiting b-lactamases by sulfonylation using b-sultams Bioorganic & Medicinal Chemistry Letters , 13 (24), pp. 4489-4492. ISSN 0960-894X

Paul, R., Bell, Z., Jeffery, J., Harding, L., McCleverty, J. and Ward, M. (2003) ‘Complexes of a bis-bidentate ligand with d10 ions: a mononuclear complex with Ag(I), and a tetrahedral cage complex with Zn(II) which encapsulates a fluoroborate anionPolyhedron , 22 (5), pp. 781-787. ISSN 02775387

Rice, C., Baylies, C., Harding, L., Jeffery, J., Paul, R. and Ward`, M. (2003) ‘Cadmium-containing pyridyl–thiazole complexes: crystal structures and solution behaviour of mononuclear, dinuclear double helicate and dinuclear triple helicate complexesPolyhedron , 22 (5), pp. 755-762. ISSN 02775387

Harding, L., Marshall, V., Elvin, M., Gu, Y. and Laws, A. (2003) ‘Structural characterisation of a perdeuteriomethylated exoploysaccharide by NMR spectroscopy: characterisation of the novel exopolysaccharide produced by Lactobacillus delbrueckii subsp. Bulgaricus EU23Carbohydrate Research , 338 (1), pp. 61-67. ISSN 0008-6215

Bell, Z., Harding, L. and Ward, M. (2003) ‘Self-assembly of a molecular M8L12 cube having S6 symmetryElectronic supplementary information (ESI) available: Fig. S1 and S2. See http://www.rsc.org/suppdata/cc/b3/b307172n/Chemical Communications (19), pp. 2432-2433. ISSN 1359-7345

2001

Rice, C., Baylies, C., Harding, L., Jeffery, J. and Paul, R. (2001) ‘Pyridyl-thiazole multidentate ligands: metal-specific recognition of a combination of ligands from a mixtureJournal of the Chemical Society Dalton Transactions (20), pp. 3039-3044. ISSN 1472-7773

Research Degree Supervision

I currently have two PhD students and a placement student working in my group.

Current group members

  • Rizwana Sadiq, PhD student: Synthesis of coordination complexes incorporating biologically-relevant molecules
  • Joshua Higginson, PhD student (with Prof. Craig Rice): Preparation of functional metallosupramolecular complexes
  • Roger Thornton, placement student

Former group members

  • Dr Amira Ahmed, (co-supervised with Prof. Henry Chrystyn)
    Br. J. Clin. Pharmacol., (2012), 74, 456–464
  • Dr Nicola Cox
    Dalton Trans., (2012), 41, 1568-1573
  • Robert Faulkner, placement student (2009-10)
    Angew. Chem. Int. Ed., (2010), 49, 6655-6658
  • Oliver Clegg, placement student (2010-11)
    Dalton Trans., (2011), 40, 12381-12387
  • Bill Rogerson, placement student (2011-12)
  • James Townend, placement student (2011-12)
  • • John Miller, placement student (2012-13), Acta Cryst. (2013), E69, m526, Acta Cryst. (2013), E69, m527
Last updated Thursday 6 March 2014
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