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In the last 10 years I gained considerable experience in pharmacological research at the University of Bradford. I independently and collaboratively supervised PhD programmes and undergraduate projects. I worked as a postdoctoral research assistant (4 years) and then as a career development lecturer in the School of Pharmacy, University of Bradford. My main work focused on gastrointestinal disturbance induced by motion, cancer chemotherapeutics agents and other drugs. My task was receptor characterisation and sensitivity assessment (for the major neurotransmitters) under normal physiological and pathological conditions. Linked to this work was a growing interest in bacterial effects on gastrointestinal motility. Consultations with microbiologists and a thorough literature research revealed little pharmacological data on Enteroaggregative E-coli-induced diarrhoea. Thus, I initiated a pilot study in Bradford to examine the effects of a new strain of E-coli, EAEC, on the intestine with an ultimate aim to develop a new vaccine candidate. In July 2008, I was offered a Senior Lectureship in Pharmacology in Huddersfield.
I have had collaborations with industry such as GlaxoSmithKline and GW pharmaceuticals and have filled 2 patents on the effects of cannabinoids on emesis. I have ongoing collaboration with the GW pharmaceuticals with an aim to identify anticancer properties of non-psychoactive cannaboniods.
My research interests focus on how disease processes or abnormalities modify the function of the gastrointestinal tract and also the mechanisms of actions of drugs affecting this system. There is a special interest in establishing the precise involvement and interaction between central and peripheral serotonergic, cannabinoids, neurokinin and other peptidergic systems relevant to significant therapeutic advances in gastrointestinal disorders such as irritable bowel syndrome (IBS) and/or inflammatory bowel disease (IBD).
I have also been involved in a research collaboration with the GW Pharmaceuticals to investigate the anti-cancer effects of non-psychoactive cannabinoids on a variety of tumour cells. Further research are under way to also investigate the anti-inflammatory actions of phytocannabinoids and other herbal medicine.
In summary my Research Interests are:
Javid, F., Bulmer, D., Broad, J., Aziz, Q., Dukes, G. and Sanger, G. (2013) ‘Anti-emetic and emetic effects of erythromycin in Suncus murinus: role of vagal nerve activation, gastric motility stimulation and motilin receptors’ European Journal of Pharmacology , 699 (1-3), pp. 48-54. ISSN 0014-2999
Bolognini, D., Rock, E., Cluny, N., Cascio, M., Limebeer, C., Duncan, M., Stott, C., Javid, F., Parker , L. and Pertwee , R. (2012) ‘Cannabidiolic acid enhances 5-HT1A receptor activation and prevents vomiting in Suncus murinus and nausea-like behaviour in rats with greater potency and selectivity than cannabidiol’ British Journal of Pharmacology . ISSN 0007-1188
Afshinjavid, S., Phillips, R. and Javid, F. (2012) ‘The effect of GWP42006, a cannabinoid extract on MCF-7 human breast carcinoma cells’ pA2 Online , 10 (3), p. 496. ISSN 1741-1149
Afshinjavid, S., Cluny, N., Okeke, I. and Javid, F. (2012) ‘The effect of Enteroaggregative escherichia coli (eaec) on 5-Hydroxytryptamine (5-HT), carbachol and electrical field stimulation (EFS)-induced contraction in the rat ileum ’ pA2 Online , 10 (3), p. 350. ISSN 1741-1149
Batista Lobo, S., Denyer, M., Britland, S. and Javid, F. (2011) ‘The Involvement of the Serotonergic Transmission System in Neonatal and Adult Rat Ileum Contractility Varies with Age’ Pharmacology , 88 (3-4), pp. 225-232. ISSN 0031-7012
Cluny, N., Naylor, R., Whittle, B. and Javid, F. (2011) ‘The effects of cannabidiolic acid and cannabidiol on contractility of the gastrointestinal tract of Suncus murinus’ Archives of Pharmacal Research , 34 (9), pp. 1509-1517. ISSN 0253-6269
Javid, F., Afshinjavid, S., Phillips, R., Stott, C. and Ayerakwa, L. (2011) ‘The effect of CBD(BDS) botanical cannabinoid extraction on MCF-7 human breast carcinoma cells.’. In: 21st Annual Symposium of the International Cannabinoid Research Society 2011. Pheasant Run, St Charles Illinois, USA: International Cannabinoid Research Society. p. 120. ISBN 978-0-9786040-6-6
Farajian-Mashradi, F., Naylor, R. and Javid, F. (2010) ‘The effect of fluoxetine on electrical field stimulation-induced responses in the isolated rat small intestine’ Methods and Findings in Experimental and Clinical Pharmacology , 32 (9), pp. 645-656. ISSN 0379-0355
Javid, F (2010) ‘The effects of 5-HT and electrical field stimulation (EFS) in the bladder of suncus murinus’. In: WorldPharma, July 17th-22nd, Copenhagen
Lobo, S., Denyer, M. and Javid, F. (2010) ‘Intestinal model of Inflammation in primary cells’. In: Inflammation conference, 27-30th January 2010, Luxembourg
Soon, C., Youseffi, M., Blagden, N., Lobo, S., Javid, F. and Denyer, M. (2009) ‘Characterisation and biocompatibility study of nematic and cholesteric liquid crystals’. In: Medical Physics and Biomedical Engineering World Congress 2009, Sept 7-12, 2009, Munich, Germany
Khaghani, S., Denyer, M., Youseffi, M., Lobo, S. and Javid, F. (2009) ‘Effect of transforming growth factor-beta (TGF-?1) in biological regulation of primary chondrocyte’. In: 15th International Biomedical Science and Technology Symposium, 16 - 19 August 2009, Cyprus
Khaghani, S., Denyer, M., Youseffi, M., Lobo, S. and Javid, F. (2009) ‘Purification of Primary Chondrocyte Cells extracted from knee joint of Sprague-Dawley rats’. In: The Anatomical Society Winter Meeting, 6th-8th January 2009, Oxford, UK
Javid, F. and McCurrie, J. (2008) Clinical Physiology and Pharmacology: The Essentials . London, UK: Wiley Blackwell . ISBN 978-0-470-51852-6
Lobo, S., Denyer, M., Gopalan, R. and Javid, F. (2008) ‘Technique for cryopreservation of intestinal smooth muscle cells’ Cryobiology , 57 (2), pp. 186-189. ISSN 00112240
Cluny, N., Naylor, R., Whittle, B. and Javid, F. (2008) ‘The Effects of Cannabidiol and Tetrahydrocannabinol on Motion-Induced Emesis in Suncus murinus’ Basic and Clinical Pharmacology and Toxicology , 103 (2), pp. 150-156. ISSN 17427835
Jamil, M., Sefat, F., Denyer, M., Khaghani, S., Batista Lobo, S., Javid, F., Youseffi, M., Britland, S., Liu, S., See, C. and Somekh, M. (2008) ‘Cell imaging with the widefield surface plasmon microscope’. In: 4th Kuala Lumpur International Conference on Biomedical Engineering 2008. Berlin: Springer. pp. 528-531. ISBN 1680-0737
Batista Lobo, S., Denyer, M., Britland, S. and Javid, F. (2007) ‘Development of an intestinal cell culture model to obtain smooth muscle cells and myenteric neurones’ Journal of Anatomy , 211 (6), pp. 819-829. ISSN 00218782
Javid, F (2006) ‘The effect of the 5-HT1A receptor agonist, 8-OH-DPAT, on motion-induced emesis in Suncus murinus ’ Pharmacology Biochemistry and Behavior , 85 (4), pp. 820-826. ISSN 00913057
Javid, F (2002) ‘The effect of serotonin and serotonin receptor antagonists on motion sickness in Suncus murinus’ Pharmacology Biochemistry and Behavior , 73 (4), pp. 979-989. ISSN 00913057
Javid, F (2001) ‘Opioid receptor involvement in the adaptation to motion sickness in Suncus murinus’ Pharmacology Biochemistry and Behavior , 68 (4), pp. 761-767. ISSN 00913057
Javid, F (1999) ‘Characterisation of 5-HT2 receptor subtypes in the Suncus murinus intestine’ European Journal of Pharmacology , 381 (2-3), pp. 161-169. ISSN 00142999
Javid, F (1999) ‘Variables of Movement Amplitude and Frequency in the Development of Motion Sickness in Suncus murinus’ Pharmacology Biochemistry and Behavior , 64 (1), pp. 115-122. ISSN 00913057
Javid, F. and Naylor, R. (1999) ‘Characterization of the 5-hydroxytryptamine receptors mediating contraction in the intestine of Suncus murinus’ British Journal of Pharmacology , 127 (8), pp. 1867-1875. ISSN 0007-1188
To investigate the mechanism of action of pathogens such as Enteroaggregative Escherichia coli (EAEC) and C.difficile on the gastrointestinal tract. Would Cannabinoids provide a solution?
The proposed project is designed to study the neuronal circuitry and the neurotransmitters involved in EAEC or C.difficil-induced diarrhoea within the enteric nervous system in rodents and human tissues. The objectives will be achieved by continuing with conventional pharmacological studies together with molecular and biochemical studies into the mechanisms and treatment of disturbed pattern of gastrointestinal motility. Such studies will also focus on investigating the role of CB receptors in inflammatory responses of gastrointestinal tract. Such studies will be designed to investigate the mechanism of actions of non-psychoactive cannabinoids such as CBD, CBDA and THCA, and perhaps some other synthetic agonists in normal and diseased epithelial cells.