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Portrait of Dr El Hassane Larhrib Dr El Hassane Larhrib

e.larhrib@hud.ac.uk | 01484 473051



Biography

Dr Larhrib was educated at the University of Sciences and Technology and the Faculty of Pharmacy, Lille, France where he obtained an MSc Biochem, DU Pharm, DESS Pharm. Tech. and a certificate in Pharm. Chemistry. He moved to the UK to do a PhD at Liverpool John Moores University, using high speed compaction simulation to study the mechanism of compaction of pharmaceutical powders under the supervision of Dr. James Wells and Prof. Mike Rubinstein. Following his PhD, Dr Larhrib worked for four years as Senior Research Fellow in particle engineering and aerosol formulation & design at the Department of Pharmacy, King’s College London. He then moved to Liverpool John Moores University as a Senior Lecturer in Pharmaceutics for five years before joining Solid Solution Limited in Liverpool. He was involved in cosmetic product development and manufacture. He moved to Medway School of Pharmacy before joining the University of Huddersfield as a Senior Lecturer in Pharmaceutics in July 2011.

Research & Scholarship

  • Mechanism of compaction of pharmaceutical powders.
  • Particle Engineering to enhance therapeutic value of medicines.
  • Pulmonary drug delivery: Formulation design to maximise drug delivery to the lungs.
  • Skin care product development using natural and certified organic ingredients

Publications and Other Research Outputs

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'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2012', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '10', 'event_dates' => undef, 'fulltimestamp' => '20120000', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '10', 'number' => undef, 'rev_number' => '10', 'edit_lock_user' => '6', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '0', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'El Hassan', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'Q1', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '11', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '2', 'datestamp_day' => '2', 'abstract' => 'The aim of this work was to investigate the mechanistic evaluation of physicochemical properties of new engineered lactose on aerosolisation performance of salbutamol sulphate (SS) delivered from dry powder inhaler (DPI). Different crystallised lactose particles were obtained from binary mixtures of butanol:acetone. The sieved fractions (63–90 ?m) of crystallised lactose were characterised in terms of size, shape, flowability, true density and aerosolisation performance (using multiple twin stage impinger (MSLI), Aerolizer® inhaler device, and salbutamol sulphate as a model drug). Compared to commercial lactose, crystallised lactose particles were less elongated, covered with fine lactose particles, and had a rougher surface morphology. The crystallised lactose powders had a considerably lower bulk and tap density and poorer flow when compared to commercial lactose. Engineered carrier with better flow showed improved drug content homogeneity, reduced amounts of drug “deposited” on the inhaler device and throat, and a smaller drug aerodynamic diameter upon inhalation. Aerodynamic diameter of salbutamol sulphate increased as lactose aerodynamic diameter decreased (linear, R2 = 0.9191) and/or as fine particle lactose content increased (linear, R2 = 0.8653). Improved drug aerosolisation performance in the case of crystallised lactose particles was attributed to lower drug–carrier adhesion forces due to a rougher surface and higher fine particle content. In conclusion, this work proved that using binary combinations of solvents in crystallisation medium is vital in modification of the physicochemical and micromeritic properties of carriers to achieve a desirable aerosolisation performance from DPI formulations. Among all lactose samples, lactose particles crystallised from pure butanol generated the highest overall DPI formulations desirability. 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'http://dx.doi.org/10.1039/9781849735148-00113', 'succeeds' => undef, 'datestamp_month' => '3', 'commentary' => undef, 'lastmod_day' => '28', 'publisher' => 'The Royal Society of Chemistry', 'pagerange' => '113-119', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2013', 'book_title' => 'Particulate Materials: Synthesis, Characterisation, Processing and Modelling', 'thesis_name' => undef, 'event_location' => undef, 'type' => 'book_section', 'publication' => undef, 'lastmod_second' => '12', 'place_of_pub' => 'London, UK', 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => undef, 'datestamp_hour' => '16', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Larhrib', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '44', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 1, 'rights' => undef, 'contributors_type' => undef, 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'status_changed_minute' => '42', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '28', 'datestamp_day' => '28', 'abstract' => 'Dry Powder Inhalers (DPIs) are the result of the development of two technologies: powder technology and device technology. Particle deposition in the respiratory tract is affected by many aerosol particle properties such as particle size, shape, density, charge, and hygroscopicity.1 In particular, particle size is of great importance as it is known that particleparticle interactions within DPI formulations are related to van der Waals forces. Therefore, particle size is the most important physical property and design variable of a DPI formulation. Several studies were reported on the effect of drug particle size on DPI performance, showing that the preferred drug particle size is between 1-5 ?m.2 However, in literature, the effect of carrier particle size distribution (PSD) on drug aerosolisation efficiency has received less attention and reported in dissimilar manner.3 Nevertheless, it should be noted that there is rare studies aimed to show the effect of carrier particle size as a single variable factor on DPI performance. In this study, the effect of lactose particle size distribution on budesonide adhesion, content uniformity and in vitro aerosolisation performance was investigated.', 'creators_id' => 'e.larhrib@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '9349', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '42', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => '10.1039/9781849735148-00113', 'volume' => undef, 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2012', 'status_changed_hour' => '16', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '15244' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1349169974', 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undef, 'pedagogic_type' => undef, 'date_month' => 8, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '15244', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2012', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '10', 'event_dates' => undef, 'fulltimestamp' => '20120800', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '9', 'number' => '8', 'rev_number' => '9', 'edit_lock_user' => '6', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '0', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'El Hassan', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'Q1', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '30', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '2', 'datestamp_day' => '2', 'abstract' => 'Purpose To co-crystallise mannitol and lactose with a view to obtaining crystals with more favourable morphological features than either lactose or mannitol alone, suitable for use as carriers in formulations for dry powder inhalers (DPIs) using simultaneous engineering of lactose-mannitol mixtures. Methods Mannitol and lactose individually and the two sugars with three different ratios were crystallised/co-crystallised using anti-solvent precipitation technique. Obtained crystals were sieved to separate 63–90 ?m size fractions and then characterised by size, shape, density and in vitro aerosolisation performance. Solid state of crystallized samples was studied using FT-IR, XRPD and DSC. Results At unequal ratios of mannitol to lactose, the elongated shape dominated in the crystallisation process. However, lactose exerted an opposite effect to that of mannitol by reducing elongation ratio and increasing the crystals’ width and thickness. Crystallised ?-lactose showed different anomers compared to commercial lactose (?-lactose monohydrate). Crystallised ?-mannitol showed different polymorphic form compared to commercial mannitol (?-mannitol). Crystallised mannitol:lactose showed up to 5 transitions corresponding to ?-mannitol, ?-lactose monohydrate, ?-lactose, 5?-/3?-lactose and 4?-/1?-lactose. In vitro deposition assessments showed that crystallised carriers produced more efficient delivery of salbutamol sulphate compared to formulations containing commercial grade carriers. Conclusion The simultaneous crystallization of lactose-mannitol can be used as a new approach to improve the performance of DPI formulations. 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'creators_name_given' => 'Ali', 'creators_id' => undef }, '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '17607', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Asare-Addo', 'eprintid' => '17607', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'Kofi', 'creators_id' => 'k.asare-addo@hud.ac.uk' }, '3' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Kaialy', 'eprintid' => '17607', 'creators_name_honourific' => '', 'pos' => '3', 'creators_name_given' => 'Waseem', 'creators_id' => undef }, '2' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Hajamohaideen', 'eprintid' => '17607', 'creators_name_honourific' => '', 'pos' => '2', 'creators_name_given' => 'Mohamed J.', 'creators_id' => undef }, '5' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Larhrib', 'eprintid' => '17607', 'creators_name_honourific' => '', 'pos' => '5', 'creators_name_given' => 'El Hassan', 'creators_id' => 'e.larhrib@hud.ac.uk' } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '5', 'editors_name_honourific' => undef, 'admin_note' => undef, 'event_title' => undef, 'date_type' => 'published', 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2013', 'fileinfo' => '', 'status_changed_second' => '48', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'Aqueous And Hydro-Alcoholic Media Effects On Polyols', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 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'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'El Hassan', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'RS', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '23', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '16', 'datestamp_day' => '16', 'abstract' => 'The ingestion of drug products with alcohol can have an adverse effect on drug levels in a patient's blood. The Food and Drug Agency (FDA) issued an alert in 2005 after hydromorphone was withdrawn from the market after clinical trials showed ingestion with alcohol to potentially result in lethal drug peak plasma concentrations. The potential impact of alcohol on extended release (ER) tablet matrices and the need to develop ER matrices robust to alcohol effects has then been of interest. This study investigated the compaction properties of polyols and their effect on drug release. Polyols (erythritol, xylitol, mannitol and maltitol) with increasing hydroxyl groups were used as diluents for HPMC matrices containing theophylline. Release profiles were determined in pH 1.2 and 6.8 dissolution media with hydro-alcoholic concentrations of 5-40%. Increases in the polyols’ hydroxyl groups brought about an increase in tablet strength and a decrease in the drug release rates. This is likely due to stronger bond formation with increasing hydroxyls. The impact of alcohol on drug release was studied further for maltitol formulations. Maltitol was resilient to the presence of ethanol (5-40% v/v) at pH 1.2 (f2 = 57-74) but not at pH 6.8 (f2 = 36-48). Drug release was not different above 5% alcohol concentration at pH 6.8. The results of this in vitro study suggest that ethanol concentrations as high as 40% do not substantially alter the drug release properties of theophylline from maltitol matrix tablets. However care and consideration should be given to choice of polyol or mixture of polyols in obtaining a desired drug release profile.', 'creators_id' => 'e.larhrib@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '116', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '23', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => 'doi:10.1016/j.colsurfb.2013.05.003', 'volume' => '111', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2013', 'status_changed_hour' => '13', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '18288' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1379858019', 'creatorlist' => { '1' => 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properties of dry-powder inhalers with novel engineered mannitol particles', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/01/82/88', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'none', 'lastmod_minute' => '59', 'refereed' => 'TRUE', 'contact_email' => undef, 'copyright_holders' => undef, 'date_day' => undef, 'gscholar_impact' => undef, 'official_url' => 'http://dx.doi.org/10.4155/TDE.13.64', 'succeeds' => undef, 'datestamp_month' => '9', 'commentary' => undef, 'lastmod_day' => '22', 'publisher' => 'Future science', 'pagerange' => '879-882', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2013', 'book_title' => undef, 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'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '13', 'number' => '8', 'rev_number' => '8', 'edit_lock_user' => '3494', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '0', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Hassan', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'Q1', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '59', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '22', 'datestamp_day' => '22', 'abstract' => 'Designing an ideal carrier for dry-powder inhaler formulation is still a challenge as there is no absolute conclusion on the ideal physicochemical properties, micromeritics and morphology for a carrier', 'creators_id' => 'e.larhrib@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '9349', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '59', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => '10.4155/TDE.13.64', 'volume' => '4', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2013', 'status_changed_hour' => '13', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '15246' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1349172930', 'creatorlist' => { '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Larhrib', 'eprintid' => '15246', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'El Hassan', 'creators_id' => 'e.larhrib@hud.ac.uk' }, '3' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Nokhodchi', 'eprintid' => '15246', 'creators_name_honourific' => '', 'pos' => '3', 'creators_name_given' => 'Ali', 'creators_id' => undef }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Kaialy', 'eprintid' => '15246', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'Waseem', 'creators_id' => undef }, '2' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Ticehurst', 'eprintid' => '15246', 'creators_name_honourific' => '', 'pos' => '2', 'creators_name_given' => 'Martyn', 'creators_id' => undef } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '10', 'editors_name_honourific' => undef, 'admin_note' => undef, 'event_title' => undef, 'date_type' => 'published', 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2012', 'fileinfo' => '/style/images/fileicons/application_pdf.png;/15246/1/Larhribcg300224w.pdf', 'status_changed_second' => '58', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'Influence of Batch Cooling Crystallization on Mannitol Physical Properties and Drug Dispersion from Dry Powder Inhalers', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/01/52/46', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'public', 'lastmod_minute' => '15', 'refereed' => 'TRUE', 'contact_email' => 'e.larhrib@hud.ac.uk', 'copyright_holders' => undef, 'date_day' => undef, 'gscholar_impact' => undef, 'official_url' => 'http://dx.doi.org/10.1021/cg300224w', 'succeeds' => undef, 'datestamp_month' => '10', 'commentary' => undef, 'lastmod_day' => '2', 'publisher' => 'ACS Publications', 'pagerange' => '3006-3017', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2012', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'Crystal Growth & Design', 'lastmod_second' => '47', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '1528-7483', 'datestamp_hour' => '9', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Larhrib', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '58', 'note' => 'Reprinted with permission from Cryst. Growth Des., 2012, 12 (6), pp 3006–3017 DOI: 10.1021/cg300224w Copyright 2012 American Chemical Society. ', 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 5, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '15246', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2012', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '10', 'event_dates' => undef, 'fulltimestamp' => '20120500', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '10', 'number' => '6', 'rev_number' => '12', 'edit_lock_user' => '6', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '0', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'El Hassan', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'Q1', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '46', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '2', 'datestamp_day' => '2', 'abstract' => 'This study provides, for the first time, an evaluation of the physicochemical properties of batch cooling crystallized mannitol particles combined with how these properties correlated with the inhalation performance from a dry powder inhaler (Aerolizer). The results showed that the type of polymorph changed from ?-form (commercial mannitol) to mixtures of ?- + ?-mannitol (cooling crystallized mannitol crystals). In comparison to mannitol particles, crystallized at a higher supersaturation degree, a lower degree of supersaturation favored the formation of mannitol crystals with a more regular and elongated habit, smoother surface, higher specific surface area, higher fine particle content, higher bulk density, and higher tap density. Cooling crystallized mannitol particles demonstrated considerably lower salbutamol sulfate–mannitol adhesion in comparison to commercial mannitol, with a linear reduction as surface roughness decreased and fines content increased. Also, mannitol crystals with smoother surfaces demonstrated a reduction in salbutamol sulfate content uniformity (expressed as %CV) within salbutamol sulfate–mannitol formulations. Despite the different physical properties, all mannitol products showed similar flow properties and similar emission of salbutamol sulfate upon inhalation. However, mannitol crystals grown from lower supersaturation (reduced roughness and increased fines) generated a finer aerodynamic size distribution and consequently deposited higher amounts of salbutamol sulfate on lower stages of the impactor. Regression analysis indicated linear relationships showing higher fine particle fraction of salbutamol sulfate in the case of mannitol particles having a more elongated shape, higher fines content, higher specific surface area, higher bulk density, and higher tap density. In conclusion, a cooling crystallization technique could be controlled to produce mannitol particles with controlled physical properties that could be used to influence aerosolization performance of a dry powder inhaler product. ', 'creators_id' => 'e.larhrib@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '6', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '46', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => 'doi:10.1021/cg300224w', 'volume' => '12', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2012', 'status_changed_hour' => '9', 'gscholar_cluster' => undef, 'producers_name_family' => undef } };

2013

Asare-Addo, K., Conway, B., Hajamohaideen, M., Kaialy, W., Nokhodchi, A. and Larhrib, E. (2013) ‘Aqueous And Hydro-Alcoholic Media Effects On PolyolsColloids and Surfaces B: Biointerfaces , 111, pp. 24-29. ISSN 0927-7765

Nokhodchi, A. and Larhrib, H. (2013) ‘Overcoming the undesirable properties of dry-powder inhalers with novel engineered mannitol particlesTherapeutic Delivery , 4 (8), pp. 879-882. ISSN 2041-5990

2012

Kaialy, W., Larhrib, E., Martin, G. and Nokhodchi, A. (2012) ‘The Effect of Engineered Mannitol-Lactose Mixture on Dry Powder Inhaler PerformancePharmaceutical Research , 29 (8), pp. 2139-2156. ISSN 0724-8741

Kaialy, W., Larhrib, E., Ticehurst, M. and Nokhodchi, A. (2012) ‘Influence of Batch Cooling Crystallization on Mannitol Physical Properties and Drug Dispersion from Dry Powder InhalersCrystal Growth & Design , 12 (6), pp. 3006-3017. ISSN 1528-7483

Kaialy, W., Larhrib, E. and Nokhodchi, A. (2012) ‘The effect of carrier particle size on adhesion, content uniformity and inhalation performance of budesonide using dry powder inhalers’. In: Particulate Materials: Synthesis, Characterisation, Processing and Modelling. London, UK: The Royal Society of Chemistry. pp. 113-119. ISBN 978-1-84973-514-8

Kaialy, W., Martin, G., Larhrib, E., Ticehurst, M., Kolosionek, E. and Nokhodchi, A. (2012) ‘The influence of physical properties and morphology of crystallised lactose on delivery of salbutamol sulphate from dry powder inhalersColloids and Surfaces B: Biointerfaces , 89, pp. 29-39. ISSN 09277765

Research Degree Supervision

Self funded PhD candidates are welcomed to apply in the following research areas:

  • Engineering drug co-crystals for pulmonary drug delivery. Physicochemical characterisation, formulation and drug delivery in-vitro.
  • Nano-Co-crystal engineering to improve the solubility and bioavailability of poorly water soluble drugs.
  • Engineering long time-of-flight carrier particles for improved drug deposition to the lungs.
  • Use of freeze fracturing technique developed in house to engineer low density, aerodynamic drug particles for inhalation.
  • Engineering spherical crystals of drugs and excipients for tablet direct compression.
  • Developing topical formulations containing a botanical complex for treating skin conditions: dermatitis, eczema, psoriasis and acne.

Applications are welcomed from potential students with an interest in skin delivery, particle engineering, formulation design and delivery in-vitro of inhaled products, mechanism of compaction of pharmaceutical powders.

Last updated Thursday 6 March 2014
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