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Portrait of Dr Alan Smith Dr Alan Smith

a.m.smith@hud.ac.uk | 01484 472305



Biography

Dr Smith graduated from Salford University (Biochemical Science) in 1997 before gaining his PhD from Cranfield University developing polysaccharide substitutes for gelatin in the production of pharmaceutical capsules under the supervision of Prof. Ed Morris. Following his PhD Dr Smith worked for 2 years as a formulation scientist within the pharmaceutical industry before taking up a position as a polysaccharide chemist at Industrial Research Limited, Wellington, New Zealand. On his return to the UK Dr. Smith has worked as a post doctoral research fellow at the University of Birmingham (School of Dentistry) and Aston University (School of Pharmacy) developing 3D cell scaffolds and polysaccharide based drug delivery systems. In 2008 he joined the tissue regeneration and interface laboratory within Chemical Engineering at the University of Birmingham where he continued to develop his research on biopolymers for tissue engineering and drug delivery applications before being appointed as a Senior Lecturer in Pharmaceutics at the University of Huddersfield in March 2011.

Research & Scholarship

Dr Smiths’s research focuses on pharmaceutical and medical applications of biopolymers. Biopolymers are a versatile class of materials which exhibit easily tailorable properties that are advantageous in developing bio-responsive drug delivery systems and functional cell culture substrates.

Cell Encapsulation and Delivery

Polysaccharides hydrogels provide an extremely mild and simple route to 3D cell immobilisation providing the cells with an environment that is similar to natural extracellular matrix. In collaboration with the University of Birmingham Dr Smith is developing these hydrogels to enable the culture of multiple cell types within a single 3D structure. He is also interested in how the mechanical properties of hydrogels change in physiological and cell culture conditions and how this impacts on the phenotype of encapsulated cells. In addition to this, he is also investigating how the extent of diffusion of molecules through different hydrogels effect tissue development.

Bioadhesion

The ability to retain a drug or cells at the site of action is an important consideration for many localised applications such as wound healing and ocular drug delivery. Biopolymers in particular, can interact with physiological secretions via physical interactions allowing sustained delivery of therapeutic molecules. Currently, Dr Smith is investigating how modification of various biopolymers can enhance bioadhesion and increase drug retention time.

Dosage form development

Within this research theme Dr Smith is interested in developing modified release formulations for oral delivery by utilizing the physiological responsive nature of biopolymers. In particular, developing novel enteric pharmaceutical capsules (Patent No. WO/2008/119943) and enteric oral liquid formulations.

Publications and Other Research Outputs

2014

Abodinar, A., Smith, A. and Morris, G. (2014) ‘A novel method to estimate the stiffness of carbohydrate polyelectrolyte polymers based on the ionic strength dependence of zeta potentialCarbohydrate Polymers , 112, pp. 6-9. ISSN 0144-8617

Ghori, M., Ginting, G., Smith, A. and Conway, B. (2014) ‘Simultaneous quantification of drug release and erosion from hypromellose hydrophilic matricesInternational Journal of Pharmaceutics , 465 (1-2), pp. 405-412. ISSN 0378-5173

Morris, G., Smith, A. and Kontogiorgos, V. (2014) ‘Editorial: Special Issue of Food Hydrocolloids: Bridging the Divide Food Hydrocolloids . ISSN 0268-005X

Smith, A., Fleming, L., Wudebwe, U., Bowen, J. and Grover, L. (2014) ‘Development of a synovial fluid analogue with bio-relevant rheology for wear testing of orthopaedic implantsJournal of the Mechanical Behavior of Biomedical Materials . ISSN 17516161

Ghori, M., Alba, K., Smith, A., Conway, B. and Kontogiorgos, V. (2014) ‘Okra Extracts In Pharmaceutical And Food ApplicationsFood Hydrocolloids . ISSN 0268005X

2013

Asare-Addo, K., Mahdi, M. and Smith, A. (2013) ‘Development of modified release paediatric liquids’. In: 5th EuPFI Conference, 18th-19th Spain 2013, Barcelona, Spain , pp. 31-32

2012

Smith, A., Hunt, N., Shelton, R., Birdi, G. and Grover, L. (2012) ‘Alginate hydrogel has a negative impact on in vitro collagen 1 deposition by fibroblastsBiomacromolecules , 13 (2), pp. 4032-4038. ISSN 1525-7797

Jamshidi, P., Ma, P., Khosrowyar, K., Smith, A. and Grover, L. (2012) ‘Tailoring gel modulus using dispersed nanocrystalline hydroxyapatiteJournal of Experimental Nanoscience , 7 (6), pp. 652-661. ISSN 1745–8080

Grover, L. and Smith, A. (2012) ‘Hydrocolloids and Medicinal Chemistry Applications. In Handbook of Biopolymers and Biodegradable Plastics’. In: Handbook of Biopolymers and Biodegradable Plastics. : Elsevier. pp. 365-384. ISBN 978-1-4557-2834-3

Birdi, G., Bridson, R., Smith, A., Bohari, S. and Grover, L. (2012) ‘Modification of alginate degradation properties using orthosilicic acidJournal of the Mechanical Behavior of Biomedical Materials , 6, pp. 181-187. ISSN 1751-6161

2011

Smith, A (2011) ‘Degradation of polysaccharide hydrogels seeded with bone marrow stromal cells Journal of the Mechanical Behavior of Biomedical Materials , 4 (7), pp. 1157-1166. ISSN 1751-6161

Buselli, E., Smith, A., Grover, L., Levi, A., Allman, R., Mattoli, V., Menciassi, A. and Beccai, L. (2011) ‘Development and characterization of a bio-hybrid skin-like stretchable electrodeMicroelectronic Engineering , 88 (8), pp. 1676-1680. ISSN 0167-9317

Smith, A (2011) ‘Inorganic Reinforcement of Alginate Hydrogel’. In: 2011 Materials Research Society Spring Meeting & Exhibit, 25th-29th April 2011, San Francisco, California

Smith, A. and Miri, T. (2011) ‘Alginates in Foods’. In: Practical food rheology: an interpretive approach. : Wiley. pp. 113-132. ISBN 9781444391060

2010

Hunt, N., Smith, A., Gbureck, U., Shelton, R. and Grover, L. (2010) ‘Encapsulation of fibroblasts causes accelerated alginate hydrogel degradationActa Biomaterialia , 6 (9), pp. 3649-3656. ISSN 1742-7061

Perrie, Y. and Smith, A.(2010) Enteric Pharmaceutical Capsules. US20100113620.

Mehrban, N., Hunt, N., Smith, A. and Grover, L. (2010) ‘A comparative study of iota carrageenan, kappa carrageenan and alginate hydrogels as tissue engineering scaffolds’. In: Gums and stabilisers for the food industry . : Royal Society of Chemistry. pp. 407-413. ISBN 9781847558312

Smith, A., Jaime-Fonseca, M., Grover, L. and Bakalis, S. (2010) ‘Alginate-Loaded Liposomes Can Protect Encapsulated Alkaline Phosphatase Functionality When Exposed to Gastric pHJournal of Agricultural and Food Chemistry , 58 (8), pp. 4719-4724. ISSN 0021-8561

AlHusban, F., ElShaer, A., Kansara, J., Smith, A., Grover, L., Perrie, Y. and Mohammed, A. (2010) ‘Investigation of Formulation and Process of Lyophilised Orally Disintegrating Tablet (ODT) Using Novel Amino Acid CombinationPharmaceutics , 2 (1), pp. 1-17. ISSN 1999-4923

Smith, A., Ingham, A., Grover, L. and Perrie, Y. (2010) ‘Polymer film formulations for the preparation of enteric pharmaceutical capsulesJournal of Pharmacy and Pharmacology , 62 (2), pp. 167-172. ISSN 0022-3573

2009

Mehrban, N., Smith, A. and Grover, L. (2009) ‘Evaluation of iota-carrageenan as a Potential Tissue Engineering Scaffold’. In: 8th World Congress of Chemical Engineering (WCCE8), August 23 to 27, 2009, Montréal, Canada

Grover, L. and Smith, A. (2009) ‘Hydrocolloids and Medicinal Chemistry Applications’. In: Modern Biopolymer Science: Bridging the Divide between Fundamental Treatise and Industrial Application . : Elsevier. pp. 595-618. ISBN 9780123741950

Chandrasekhar, R., Hassan, Z., AlHusban, F., Smith, A. and Mohammed, A. (2009) ‘The role of formulation excipients in the development of lyophilised fast-disintegrating tabletsEuropean Journal of Pharmaceutics and Biopharmaceutics , 72 (1), pp. 119-129. ISSN 0939-6411

Smith, A., Grover, L., Jaime-Fonseca, M., Yahya, F. and Bakalis, S. (2009) ‘Encapsulation and Stability of bioactive proteins in gel loaded liposomes’. In: 5th International Symposium on Food Rheology and Structure, 2009, ETH Zurich

2008

Clark, S., Cross, M., Smith, A., Court, P., Vipond, J., Nadian, A., Hewison, R., Batchelor, H., Perrie, Y., Williams, A., Aldwell, F. and Chambers, M. (2008) ‘Assessment of different formulations of oral Mycobacterium bovis Bacille Calmette-Guérin (BCG) vaccine in rodent models for immunogenicity and protection against aerosol challenge with M. bovisVaccine , 26 (46), pp. 5791-5797. ISSN 0264-410X

Smith, A., Jarved, O., Batchelor, H. and Perrie, Y. (2008) ‘Bacille Calmette–Gue´ rin (BCG)-loaded alginate beads as a potential oral tuberculosis vaccine for wildlifeJournal of Pharmacy and Pharmacology , 60 (S1). ISSN 0022-3573

Harris, J., Smith, A., Campbell-Lynch, S. and Shelton, R. (2008) ‘Dramatic changes in bulk deformation behaviour of gellan gum on cross-linking with mixed cations’. In: Gums and Stabilisers for the Food Industry . : Royal Society of Chemistry. pp. 79-86. ISBN 9780854044610

2007

Smith, A., Shelton, R., Perrie, Y. and Harris, J. (2007) ‘An Initial Evaluation of Gellan Gum as a Material for Tissue Engineering ApplicationsJournal of Biomaterials Applications , 22 (3), pp. 241-254. ISSN 0885-3282

Smith, A., Basra, A., Batchelor, H. and Perrie, Y. (2007) ‘Alginate Beads as Potential Oral Vaccine Delivery Platforms: Effect of Coating Journal of Pharmacy and Pharmacology , 59 (s1), p. A55. ISSN 0022-3573

Agoub, A., Smith, A., Giannouli, P., Richardson, R. and Morris, E. (2007) ‘“Melt-in-the-mouth” gels from mixtures of xanthan and konjac glucomannan under acidic conditions: A rheological and calorimetric study of the mechanism of synergistic gelationCarbohydrate Polymers , 69 (4), pp. 713-724. ISSN 0144-8617

Smith, A., Harris, J., Shelton, R. and Perrie, Y. (2007) ‘3D culture of bone-derived cells immobilised in alginate following light-triggered gelationJournal of Controlled Release , 119 (1), pp. 94-101. ISSN 0168-3659

2006

Smith, A., Harris, J., Shelton, R. and Perrie, Y. (2006) ‘3D Culture of bone-derived cells following light triggered gelation of alginate by Ca2+ release from photosensitive liposomesJournal of Pharmacy and Pharmacology , 58 (S1), p. A51. ISSN 0022-3573

2005

Smith, A., Shelton, R., Harris, J. and Perrie, Y. (2005) ‘Formation of alginate hydrogel scaffolds for tissue engineering by light activated release of calcium from photosensitive liposomesJournal of Pharmacy and Pharmacology , 57 (S1), p. S42. ISSN 0022-3573

Research Degree Supervision

Opportunities for self funded PhD studies are available in the following research areas

  • Injectable cell culture substrates for tissue regeneration
  • Development of modified release oral liquid formulations for pediatrics
  • Developing bioresponsive hydrogels for tissue engineering applications

Applications are welcome from potential students with an interest in formulation development or the physicochemical properties of macromolecules.

Last updated Thursday 6 March 2014
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