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Portrait of Professor Barbara Conway Professor Barbara Conway

b.r.conway@hud.ac.uk | 01484 472347



Biography

Barbara was appointed as Professor of Pharmaceutics at the University of Huddersfield in 2010. Following her first degree in Pharmacy at Queen’s University, Belfast, she registered as a pharmacist in 1990 and practised full-time in community pharmacy until joining Aston University in Birmingham in 1992 to undertake a Ph.D. Her PhD research project at Aston was in the pharmaceutics and drug delivery field, focusing on microencapsulation for delivery of biopharmaceuticals.

Following completion of her PhD studies in 1995, she was employed in various posts at Aston University, including lecturer and senior lecturer and was Director of the M.Pharm. programme prior to moving to the University of Huddersfield in 2010 as Professor of Pharmaceutics. During this time, she also became a Fellow of the Higher Education Academy and supervised projects on the application of e-learning technologies in Pharmacy. She was also a Medici Fellow, specialising in driving forward innovation within the university sector and hold several patents in the pharmaceutical area. She has supervised over 20 Ph.D. students and on-going research programmes focus on chrontherapeutic delivery and delivery of antimicrobials, novel excipients for drug delivery, the mechanical properties of pharmaceuticals and excipients and the development of chewing gum delivery systems.

She has a number of successful collaborations with other universities, NHS and pharmaceutical industry leading to publications and development of new products.

Research & Scholarship

Her research encompasses the improvement of traditional and development of novel drug formulations in relation to stability, bioavailability and patient compliance. A major barrier to introduction of new chemical entities onto the market as novel therapeutics is the design of efficient delivery systems for drugs that are poorly soluble, unstable, or are of low permeability. Research in the group focuses on application of pharmaceutics, with the aim of improving delivery of challenging molecules through biological membranes and barriers with particular emphasis on rational formulation design and the introduction of innovation.

Understanding the fundamental physical properties of delivery systems in relation to their performance is key and one research strand focuses on the characterising the relationship between solid state properties and the performance of pharmaceutical materials, for example the prediction of mechanical properties of salt forms of drugs based on their crystal structures with a view to improving processing.

Other research strands involve the development of formulations for oral, ophthalmic and transdermal drug delivery, the design of modified release systems, including the use of mucoadhesives, fast-dissolving and chewing gum formulations and the enhancement of solubility and dissolution for poorly soluble drugs. It is essential to address both physiological and physiochemical barriers to drug absorption with a view to developing improved formulation strategies in clinical practice, for example, effective delivery of antiseptics into the lower layers of the skin to improve asepsis.

Publications and Other Research Outputs

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It is associated with the development of serious gastroduodenal disease - including peptio ulcers, gastric lymphoma and acute chronic gastritis. It Is associated with the development of serious gastroduodenal disease - Including peptio ulcers, gastric lymphoma and acute chronic gastritis. Current recommended regimes are not wholly effective and patient compliance, side-effects and bacterial resistance can be problematic. Current recommended regimes are not Wholly effective and patient compliance, side effects and bacterial resistance can Be Problematic. Drug delivery to the site of residence in the gastric mucosa may improve efficacy of the current and emerging treatments. Drug delivery to the site of the residence in gastric mucosa May Improve Efficacy of the Current and Emerging treatments. Gastric retentive delivery systems potentially allow increased penetration of the mucus layer and therefore increased drug concentration at the site of action. Gastric retentive delivery systems INcreased Potentially allow penetration of the mucus layer and drug concentration Therefor INcreased at the site of action. Proposed gastric retentive systems for the enhancement of local drug delivery include floating systems, expandable or swellable systems and bioadhesive systems. Proposed gastric retentive systems for the enhancement of local drug delivery include floating systems, expandable or swellable systems and bioadhesive systems. Generally, problems with these formulations are lack of specificity, limited to mucus turnover or failure to persist in the stomach. Generally, formulations are thesis Problems with Lack of specificity, limited to mucus turnover or failure to persist in the stomach. Gastric mucoadhesive systems are hailed as a promising technology to address this issue, penetrating the mucus layer and prolonging activity at the mucus-epithelial interface. Gastric mucoadhesive systems are hailed as a Promising technology to address this issue, penetrating the mucus layer and Prolonging activity at the mucus-epithelial interface. This review appraises gastroretentive delivery strategies specifically with regard to their application as a delivery system to target Helicobacter. This review appraiser gastroretentive delivery strategies specifically with regard to their applications as a delivery system to target Helicobacter. As drug-resistant strains emerge, the development of a vaccine to eradicate and prevent reinfection is an attractive proposition. As drug-resistant Strains emerge, the development of a vaccine to Eradicate and Prevent reinfection ya une attractive proposal. Proposed prophylactic and therapeutic vaccines have been delivered using a number of mucosal routes using viral and non-viral vectors. Prophylactic and therapeutic vaccines Proposed Have Been Delivered using a number of mucosal routes using viral and non-viral vectors. The delivery form, inclusion of adjuvants, and delivery regime will influence the immune response generated. The delivery form, inclusion of adjuvants and delivery Will diet influence the immune response generated.', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '3483', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '26', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => undef, 'volume' => '11', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2005', 'status_changed_hour' => '8', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '8936' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1288869242', 'creatorlist' => { '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '8936', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '11', 'editors_name_honourific' => undef, 'admin_note' => undef, 'event_title' => undef, 'date_type' => 'published', 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2010', 'fileinfo' => '', 'status_changed_second' => '8', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'Recent Patents on Ocular Drug Delivery Systems ', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/00/89/36', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'none', 'lastmod_minute' => '28', 'refereed' => 'TRUE', 'contact_email' => undef, 'copyright_holders' => undef, 'date_day' => undef, 'gscholar_impact' => undef, 'official_url' => 'http://www.bentham.org/ddf/contabs/ddf2-1.htm#1', 'succeeds' => undef, 'datestamp_month' => '11', 'commentary' => undef, 'lastmod_day' => '4', 'publisher' => 'Bentham Science ', 'pagerange' => '1-8', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2010', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'Recent Patents on Drug Delivery & Formulation', 'lastmod_second' => '8', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '1872-2113', 'datestamp_hour' => '11', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '8', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 1, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '8936', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2010', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '11', 'event_dates' => undef, 'fulltimestamp' => '20080100', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '11', 'number' => '1', 'rev_number' => '6', 'edit_lock_user' => '3483', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '0', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'Q1', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '28', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '4', 'datestamp_day' => '4', 'abstract' => 'There are three main routes for delivery of drugs to the eye: topical, systemic and intra-ocular injection. Controlled delivery systems, such as ocular inserts, minitablets and disposable lenses, can be applied to the exterior surface of the eye for treatment of conditions affecting the anterior segment of the eye. Extended residence times following topical application have the potential to improve bioavailability of the administered drug and additionally a range of strategies has been tested to improve penetration including cyclodextrins, liposomes and nanoparticles. The first part of this review will focus on recent patent filings in this area. The second part of the review reports on drug delivery strategies for treatment of diseases of the posterior segment of the eye. The development of therapeutic agents that require repeated, long-term administration is a driver for the development of sustained-release drug delivery systems to result in less frequent dosing and less invasive techniques. This review article focuses on recently patented applications (from March 2004 to present) of drug delivery systems for ocular delivery', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '3483', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '28', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => undef, 'volume' => '2', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2008', 'status_changed_hour' => '11', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '11735' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1318933561', 'creatorlist' => { '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '11735', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Nep', 'eprintid' => '11735', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'Elijah I', 'creators_id' => undef } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '10', 'editors_name_honourific' => undef, 'admin_note' => 'Emailed permission SJT 18/10/11', 'event_title' => undef, 'date_type' => 'published', 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2011', 'fileinfo' => '/style/images/fileicons/application_pdf.png;/11735/1/ConwayGrewia1.pdf', 'status_changed_second' => '32', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'Grewia Gum 1: Some Mechanical and Swelling Properties of Compact and Film', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/01/17/35', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'restricted', 'lastmod_minute' => '44', 'refereed' => 'TRUE', 'contact_email' => undef, 'copyright_holders' => undef, 'date_day' => undef, 'gscholar_impact' => undef, 'official_url' => 'http://dx.doi.org/10.4314/tjpr.v10i4.3', 'succeeds' => undef, 'datestamp_month' => '10', 'commentary' => undef, 'lastmod_day' => '18', 'publisher' => 'Pharmacotherapy Group', 'pagerange' => '385-392', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2011', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'Tropical Journal of Pharmaceutical Research', 'lastmod_second' => '32', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '1596-5996', 'datestamp_hour' => '10', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '32', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 8, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '11735', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2011', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '10', 'event_dates' => undef, 'fulltimestamp' => '20110800', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '10', 'number' => '4', 'rev_number' => '8', 'edit_lock_user' => '6', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '0', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'Q1', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '44', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => '718', 'status_changed_day' => '18', 'datestamp_day' => '18', 'abstract' => 'Purpose: To study the mechanical and dynamic swelling properties of grewia gum, evaluate its compression behaviour and determine the effect of drying methods on its properties. Methods: Compacts (500 mg) of both freeze-dried and air-dried grewia gum were separately prepared by compression on a potassium bromide (KBr) press at different pressures and subjected to Heckel analysis. Swelling studies were performed using 200 mg compacts of the gum (freeze-dried or air-dried) compressed on a KBr press. The mechanical properties of the films of the gum prepared by casting 1 % dispersions of the gum were evaluated using Hounsfield tensiometer. The mechanical properties of grewia gum films were compared with films of pullulan and guar gum which were similarly prepared. The effect of temperature on the water uptake of the compacts was studied and the data subjected to Schott’s analysis. Results: Drying conditions had no effect on the yield pressure of the gum compacts as both air-dried and freeze-dried fractions had a yield pressure of 322.6 MPa. The plots based on Schott’s equation for the grewia gum samples showed that both samples (freeze-dried and air-dried) exhibited long swelling times. Grewia gum film had a tensile strength of 19.22±3.61 MPa which was similar to that of pullulan films (p > 0.05). It had an elastic modulus of 2.13±0.12 N/mm2 which was significantly lower (p < 0.05) than those of pullulan and guar gum with elastic moduli of 3.33±0.00 and 2.86±0.00 N/mm2, respectively. Conclusion: The type of drying method used does not have any effect on the degree of plasticity of grewia gum compacts. Grewia gum obtained by either drying method exhibited extended swelling duration. Matrix tablet formulations of the gum will likely swell slowly and promote sustained release of drug.', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '6', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '44', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => 'doi:10.4314/tjpr.v10i4.3', 'volume' => '10', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2011', 'status_changed_hour' => '10', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '8955' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1288948396', 'creatorlist' => { '1' => { 'creators_name_lineage' => '', 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undef, 'scopus_id' => undef, 'eprintid' => '8955', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2010', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '11', 'event_dates' => undef, 'fulltimestamp' => '20020900', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '9', 'number' => '9', 'rev_number' => '9', 'edit_lock_user' => '3483', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '1', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'QD', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '12', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '5', 'datestamp_day' => '5', 'abstract' => 'A novel dissolution method was developed, suitable for powder mixtures, based on the USP basket apparatus. The baskets were modified such that the powder mixtures were retained within the baskets and not dispersed, a potential difficulty that may arise when using conventional USP basket and paddle apparatus. The advantages of this method were that the components of the mixtures were maintained in close proximity, maximizing any drug:excipient interaction and leading to more linear dissolution profiles. Two weakly acidic model drugs, ibuprofen and acetaminophen, and a selection of pharmaceutical excipients, including potential dissolution-enhancing alkalizing agents, were chosen for investigation. Dissolution profiles were obtained for simple physical mixtures. The f1 fit factor values, calculated using pure drug as the reference material, demonstrated a trend in line with expectations, with several dissolution enhancers apparent for both drugs. Also, the dissolution rates were linear over substantial parts of the profiles. For both drugs, a rank order comparison between the f1 fit factor and calculated dissolution rate, obtained from the linear section of the dissolution profile, demonstrated a correlation using a significance level of P = 0.05. The method was proven to be suitable for discriminating between the effects of excipients on the dissolution of the model drugs. The method design produced dissolution profiles where the dissolution rate was linear for a substantial time, allowing determination of the dissolution rate without mathematical transformation of the data. This method may be suitable as a preliminary excipient-screening tool in the drug formulation development process. ', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '3483', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '12', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => 'doi:10.1081/DDC-120014581', 'volume' => '28', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2002', 'status_changed_hour' => '9', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '22120' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1413903904', 'creatorlist' => { '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '22120', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Hendry', 'eprintid' => '22120', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'Emma', 'creators_id' => undef }, '2' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Worthington', 'eprintid' => '22120', 'creators_name_honourific' => '', 'pos' => '2', 'creators_name_given' => 'Tony', 'creators_id' => 't.worthington@aston.ac.uk' } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '10', 'editors_name_honourific' => undef, 'admin_note' => undef, 'event_title' => undef, 'date_type' => 'published', 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2014', 'fileinfo' => '/style/images/fileicons/application_pdf.png;/22120/1/PMC3509563.pdf', 'status_changed_second' => '55', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'Antimicrobial efficacy of a novel eucalyptus oil, chlorhexidine digluconate and isopropyl alcohol biocide formulation.', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/02/21/20', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '1', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'public', 'lastmod_minute' => '5', 'refereed' => 'TRUE', 'contact_email' => 'b.r.conway@hud.ac.uk', 'copyright_holders' => undef, 'date_day' => 30, 'gscholar_impact' => undef, 'official_url' => 'http://dx.doi.org/10.3390/ijms131114016', 'succeeds' => undef, 'datestamp_month' => '10', 'commentary' => undef, 'lastmod_day' => '21', 'publisher' => 'MDIP', 'pagerange' => '14016-14025', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2014', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'International Journal of Molecular Sciences', 'lastmod_second' => '56', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '1422-0067', 'datestamp_hour' => '15', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '56', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 10, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '22120', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2014', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '10', 'event_dates' => undef, 'fulltimestamp' => '20121030', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '15', 'number' => '11', 'rev_number' => '8', 'edit_lock_user' => '6', 'series' => undef, 'creators_name_lineage' => '', 'pos' => undef, 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => undef, 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '5', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '21', 'datestamp_day' => '21', 'abstract' => 'Effective surface disinfection is a fundamental infection control strategy within healthcare. This study assessed the antimicrobial efficacy of novel biocide formulations comprising 5% and 2% eucalyptus oil (EO) combined with 2% chlorhexidine digluconate (CHG) and 70% isopropyl alcohol (IPA) contained within a wipe. The efficacy of this novel antimicrobial formulation to remove and eliminate methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli and Candida albicans from steel surfaces was investigated. Adpression studies of pre-contaminated wipes were also utilised to assess their potential to induce cross-contamination between hard surfaces. Furthermore, the bactericidal nature of the EO-formulation was established in addition to time-kill. The EO-containing formulations demonstrated bactericidal antimicrobial efficacy against all microorganisms and did not induce surface cross-contamination. There was no significant difference (p &lt; 0.05) between the 5% and 2% EO formulations in their ability to remove microorganisms from steel surfaces, however both significantly (p &lt; 0.05) removed more than the control formulations. Microbial biofilms were eliminated within 10 min (p &lt; 0.05) when exposed to the EO formulations. Our novel EO-formulation demonstrated rapid antimicrobial efficacy for potential disinfection and elimination of microbial biofilms from hard surfaces and may therefore be a useful adjunct to current infection control strategies currently employed within healthcare facilities.', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '21377', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '5', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => '10.3390/ijms131114016', 'volume' => '13', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2012', 'status_changed_hour' => '15', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '17947' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' 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'creators_name_family' => 'Rajabi-Siahboomi', 'eprintid' => '17947', 'creators_name_honourific' => '', 'pos' => '4', 'creators_name_given' => 'Ali R.', 'creators_id' => undef }, '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '17947', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Asare-Addo', 'eprintid' => '17947', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'Kofi', 'creators_id' => 'k.asare-addo@hud.ac.uk' }, '5' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Tetteh', 'eprintid' => '17947', 'creators_name_honourific' => '', 'pos' => '5', 'creators_name_given' => 'John', 'creators_id' => undef } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '7', 'editors_name_honourific' => undef, 'admin_note' => undef, 'event_title' => undef, 'date_type' => 'published', 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2013', 'fileinfo' => '/style/images/fileicons/application_pdf.png;/17947/1/Kofi%2Dfor_repository_database.pdf', 'status_changed_second' => '31', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'The effect of pH and ionic strength of dissolution media on in-vitro release of two model drugs of different solubilities from HPMC matrices', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/01/79/47', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'public', 'lastmod_minute' => '46', 'refereed' => 'TRUE', 'contact_email' => undef, 'copyright_holders' => undef, 'date_day' => undef, 'gscholar_impact' => undef, 'official_url' => 'http://dx.doi.org/10.1016/j.colsurfb.2013.06.034', 'succeeds' => undef, 'datestamp_month' => '7', 'commentary' => undef, 'lastmod_day' => '12', 'publisher' => 'Elsevier', 'pagerange' => '384-391', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2013', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'Colloids and Surfaces B: Biointerfaces', 'lastmod_second' => '2', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '0927-7765', 'datestamp_hour' => '14', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '31', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 11, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '17947', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2013', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '9', 'event_dates' => undef, 'fulltimestamp' => '20131100', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '10', 'number' => undef, 'rev_number' => '10', 'edit_lock_user' => '3494', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '0', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'Q1', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '52', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '12', 'datestamp_day' => '12', 'abstract' => 'The evaluation of the effects of different media ionic strengths and pH on the release of hydrochlorothiazide, a poorly soluble drug, and diltiazem hydrochloride, a cationic and soluble drug, from a gel forming hydrophilic polymeric matrix were the objectives of this study. The drug to polymer ratio of formulated tablets was 4:1. Hydrochlorothiazide or diltiazem HCl extended release (ER) matrices containing hypromellose (hydroxypropyl methylcellulose (HPMC)) were evaluated in media with a pH range of 1.2-7.5, using an automated USP type III, Bio-Dis dissolution apparatus. The ionic strength of the media was varied over a range of 0-0.4 M to simulate the gastrointestinal fed and fasted states and various physiological pH conditions. Sodium chloride was used for ionic regulation due to its ability to salt out polymers in the midrange of the lyotropic series. The results showed that the ionic strength had a profound effect on the drug release from the diltiazem HCl K100LV matrices. The K4M, K15M and K100M tablets however withstood the effects of media ionic strength and showed a decrease in drug release to occur with an increase in ionic strength. For example, drug release after the 1 hr mark for the K100M matrices in water was 36 %. Drug release in pH 1.2 after 1 hr was 30 %. An increase of the pH 1.2 ionic strength to 0.4 M saw a reduction of drug release to 26 %. This was the general trend for the K4M and K15M matrices as well. The similarity factor f2 was calculated using drug release in water as a reference. Despite similarity occurring for all the diltiazem HCl matrices in the pH 1.2 media (f2=64-72), increases of ionic strength at 0.2 M and 0.4 M brought about dissimilarity. The hydrochlorothiazide tablet matrices showed similarity at all the ionic strength tested for all polymers (f2= 56-81). The values of f2 however reduced with increasing ionic strengths. DSC hydration results explained the hydrochlorothiazide release from their HPMC matrices. There was an increase in bound water as ionic strengths increased. Texture analysis was employed to determine the gel strength and also to explain the drug release for the diltiazem hydrochloride. This methodology can be used as a valuable tool for predicting potential ionic effects related to in vivo fed and fasted states on drug release from hydrophilic ER matrices. Keywords: Ionic strength, HPMC polymeric matrix tablets, Similarity factor, Kinetics of drug release, Hydration, Diltiazem HCl, Hydrochlorothiazide. ', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '13069', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '52', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => 'doi:10.1016/j.colsurfb.2013.06.034', 'volume' => '111', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2013', 'status_changed_hour' => '14', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '13119' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1331828780', 'creatorlist' => { '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Timmins', 'eprintid' => '13119', 'creators_name_honourific' => '', 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'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'Impact of the counterion on the solubility and physicochemical properties of salts of carboxylic acid drugs', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/01/31/19', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'none', 'lastmod_minute' => '29', 'refereed' => 'TRUE', 'contact_email' => 'b.r.conway@hud.ac.uk', 'copyright_holders' => undef, 'date_day' => undef, 'gscholar_impact' => undef, 'official_url' => 'http://dx.doi.org/10.3109/03639045.2011.592530', 'succeeds' => undef, 'datestamp_month' => '3', 'commentary' => undef, 'lastmod_day' => '15', 'publisher' => 'Informa Healthcare', 'pagerange' => '93-103', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2012', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'Drug Development and Industrial Pharmacy', 'lastmod_second' => '22', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '0363-9045', 'datestamp_hour' => '16', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '22', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 1, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '13119', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2012', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '3', 'event_dates' => undef, 'fulltimestamp' => '20120100', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '16', 'number' => '1', 'rev_number' => '8', 'edit_lock_user' => '6', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '0', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'Q1', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '29', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '15', 'datestamp_day' => '15', 'abstract' => 'Aim: Salt formation is a widely used approach to improve the physicochemical and solid state properties of an active pharmaceutical ingredient. In order to better understand the relationships between the active drug, the selected counterion and the resultant salt form, crystalline salts were formed using four different carboxylic acid drugs and a closely related series of amine counterions. Thirty-six related crystalline salts were prepared, characterized and the relationship between solubility and dissolution behaviour and other properties of the salt and the counterion studied. Methods: Salts of four model acid drugs, gemfibrozil, flurbiprofen, ibuprofen and etodolac were prepared using the counterions butylamine, hexylamine, octylamine, benzylamine, cyclohexylamine, tert-butylamine, 2-amino-2-methylpropan-1-ol, 2-amino-2-methylpropan-1,3-diol andtris(hydroxymethyl)aminomethane. Salt formation was confirmed, the salts were characterized and their corresponding solubilities determined and rationalized with respect to the counterions’ properties. Results and conclusion: The properties of the salt highly dependent on the nature of the counterion and, although there is considerable variation, some general conclusion can be drawn. For the alkyl amines series, increasing chain length leads to a reduction in solubility across all the acidic drugs studied and a reduction in melting point, thus contradicting simplistic relationships between solubility and melting point. Small, compact counterions consistently produce crystalline salts with high melting point accompanied with a modest improvement in solubility and the nature of hydrogen bonding between the ions has a major impact on the solubility. ', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '6', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '29', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => 'doi:10.3109/03639045.2011.592530', 'volume' => '38', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2012', 'status_changed_hour' => '16', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '11513' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1326796755', 'creatorlist' => { '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '11513', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Adebisi', 'eprintid' => '11513', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'Adeola', 'creators_id' => undef } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '9', 'editors_name_honourific' => undef, 'admin_note' => 'Emailed author for PP SJT 20/9/11', 'event_title' => undef, 'date_type' => 'published', 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2011', 'fileinfo' => '/style/images/fileicons/application_pdf.png;/11513/1/ConwayGastropdf.pdf|/style/images/fileicons/application_msword.png;/11513/2/ConwayGastroretentive.docx', 'status_changed_second' => '31', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'Gastroretentive microparticles for drug delivery applications', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/01/15/13', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'restricted', 'lastmod_minute' => '41', 'refereed' => 'TRUE', 'contact_email' => 'b.r.conway@hud.ac.uk', 'copyright_holders' => undef, 'date_day' => undef, 'gscholar_impact' => undef, 'official_url' => 'http://dx.doi.org/10.3109/02652048.2011.590613', 'succeeds' => undef, 'datestamp_month' => '9', 'commentary' => undef, 'lastmod_day' => '17', 'publisher' => 'Informa Healthcare', 'pagerange' => '689-708', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2011', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'Journal of Microencapsulation', 'lastmod_second' => '7', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '0265-2048', 'datestamp_hour' => '11', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '31', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 8, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '11513', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2012', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '1', 'event_dates' => undef, 'fulltimestamp' => '20110800', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '10', 'number' => '8', 'rev_number' => '12', 'edit_lock_user' => '3483', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '0', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'Q1', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '7', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '20', 'datestamp_day' => '20', 'abstract' => 'Many strategies have been proposed to explore the possibility of exploiting gastroretention for drug delivery. Such systems would be useful for local delivery, for drugs that are poorly soluble at higher pH or primarily absorbed from the proximal small intestine. Generally, the requirements of such strategies are that the vehicle maintains controlled drug release and exhibits prolonged residence time in the stomach. Despite widespread reporting of technologies, many have an inherent drawback of variability in transit times. Microparticulate systems, capable of distributing widely through the gastrointestinal tract, can potentially minimise this variation. While being retained in the stomach, the drug content is released slowly at a desired rate, resulting in reduced fluctuations in drug levels. This review summarises the promising role of microencapsulation in this field, exploring both floating and mucoadhesive microparticles and their application in the treatment of Helicobacter pylori, highlighting the clinical potential of eradication of this widespread infection ', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '6', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '7', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => 'doi:10.3109/02652048.2011.590613', 'volume' => '28', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2011', 'status_changed_hour' => '11', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '11512' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1316515453', 'creatorlist' => { '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '11512', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Nep', 'eprintid' => '11512', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'Elijah I', 'creators_id' => undef } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '9', 'editors_name_honourific' => undef, 'admin_note' => 'OA but queried permission anyway SJT 20/9/11', 'event_title' => undef, 'date_type' => 'published', 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2011', 'fileinfo' => '/style/images/fileicons/application_pdf.png;/11512/1/ConwayEvaluation.pdf', 'status_changed_second' => '28', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'Evaluation of grewia polysaccharide gum as a suspending agent', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/01/15/12', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'public', 'lastmod_minute' => '53', 'refereed' => 'TRUE', 'contact_email' => undef, 'copyright_holders' => undef, 'date_day' => undef, 'gscholar_impact' => undef, 'official_url' => 'http://www.ijppsjournal.com/Vol3Issue2/2052.pdf', 'succeeds' => undef, 'datestamp_month' => '9', 'commentary' => undef, 'lastmod_day' => '20', 'publisher' => 'International Journal of Pharmacy and Pharmaceutical Sciences', 'pagerange' => '168-173', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2011', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'International Journal of Pharmacy and Pharmaceutical Sciences', 'lastmod_second' => '28', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '0975-1491', 'datestamp_hour' => '10', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '28', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 4, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '11512', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2011', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '9', 'event_dates' => undef, 'fulltimestamp' => '20110400', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '10', 'number' => '2', 'rev_number' => '8', 'edit_lock_user' => '6', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '0', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'Q1', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '53', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '20', 'datestamp_day' => '20', 'abstract' => 'Grewia polysaccharide gum was extracted from the inner stem bark of Grewia mollis, thereupon drying was achieved by air?drying (ADGG) or freeze?drying (FDGG). The suspending ability of grewia gum was compared to that of xanthan (XAN), sodium carboxymethylcellulose (SCMC) and acacia gum (ACA) in ibuprofen suspension. The physical stability of the ibuprofen suspension formulations, containing the suspending agents at a range of concentrations, was assessed by appearance and pourability, viscosity and rheology, sedimentation volume ratio, redispersibility, degree of flocculation, zeta potential and microbial load. The ADGG and FDGG?containing formulations exhibited pseudoplastic flow with a viscosity?imparting ability superior to ACA and SCMC?containing formulations, but not XAN, at all concentrations. ADGG?containing formulations (1.0 %w/v) remained fully suspended for over 42 days while all the other formulations sedimented within 24 hours except XAN?containing formulations. The FDGG and ADGG?containing formulations were more easily redispersed than SCMC?containing formulations and exhibited a higher degree of flocculation at 0.75 %w/v than ACA or SCMC?containing formulations. The zeta potential of XAN, ADGG or FDGG?containing suspension formulations were more negative than ?30 mV and therefore more stable than SCMC or ACA?containing suspension formulations (zeta potentials of < ?23 mV). All suspension formulations showed evidence of microbial growth on storage. ADGG or FDGG may provide a suitable alternative as suspending agent in pharmaceutical oral suspensions.', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '6', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '53', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => undef, 'volume' => '3', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2011', 'status_changed_hour' => '10', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '8943' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1288873352', 'creatorlist' => { '4' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Wang', 'eprintid' => '8943', 'creators_name_honourific' => '', 'pos' => '4', 'creators_name_given' => 'Y', 'creators_id' => undef }, '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Wang', 'eprintid' => '8943', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'G', 'creators_id' => undef }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Suppasansatorn', 'eprintid' => '8943', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'Panassaya', 'creators_id' => undef }, '3' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Wang', 'eprintid' => '8943', 'creators_name_honourific' => '', 'pos' => '3', 'creators_name_given' => 'W', 'creators_id' => undef }, '2' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '8943', 'creators_name_honourific' => '', 'pos' => '2', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '11', 'editors_name_honourific' => undef, 'admin_note' => undef, 'event_title' => undef, 'date_type' => 'published', 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2010', 'fileinfo' => '', 'status_changed_second' => '4', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'Skin delivery potency and antitumor activities of temozolomide ester prodrugs', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/00/89/43', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'none', 'lastmod_minute' => '27', 'refereed' => 'TRUE', 'contact_email' => undef, 'copyright_holders' => undef, 'date_day' => undef, 'gscholar_impact' => undef, 'official_url' => 'http://dx.doi.org/10.1016/j.canlet.2005.11.029', 'succeeds' => undef, 'datestamp_month' => '11', 'commentary' => undef, 'lastmod_day' => '4', 'publisher' => 'Elsevier Ireland ', 'pagerange' => '42-52', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2010', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'Cancer Letters', 'lastmod_second' => '4', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '0304-3835', 'datestamp_hour' => '12', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '4', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 1, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '8943', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2010', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '11', 'event_dates' => undef, 'fulltimestamp' => '20060100', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '12', 'number' => '1', 'rev_number' => '8', 'edit_lock_user' => '3483', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '0', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'Q1', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '27', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '4', 'datestamp_day' => '4', 'abstract' => 'Clinical trials have shown temozolomide to be an effective agent for treatment of malignant melanoma. In order to investigate its suitability for delivery via the skin, a series of temozolomide esters was synthesized as prodrugs. In vitro assays demonstrated temozolomide, temozolomide acid and the hexyl ester equi-effective against selected cancer cell lines. The susceptibility of the esters to enzyme hydrolysis and their effectiveness for application to the skin were investigated. The esters effectively diffuse through rat skin and the hexyl ester demonstrated profound potency for penetrating through skin. Topical application of 5% (w/v) hexyl ester in DMSO solution on a mouse model demonstrated a significant inhibition of tumor growth. These results suggest that temozolomide esters could be an effective alternative to temozolomide in the treatment of skin cancer.', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '3483', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '27', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => 'doi:10.1016/j.canlet.2005.11.029', 'volume' => '244', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2006', 'status_changed_hour' => '12', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '22093' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1413459071', 'creatorlist' => { '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '22093', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Kakadia', 'eprintid' => '22093', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'Pratibha G.', 'creators_id' => undef } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '10', 'editors_name_honourific' => undef, 'admin_note' => 'Emailed permission 16/10/14', 'event_title' => undef, 'date_type' => 'published', 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2014', 'fileinfo' => '/style/images/fileicons/application_pdf.png;/22093/1/ConwaySolid.pdf', 'status_changed_second' => '11', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'Solid Lipid Nanoparticles: A Potential Approach for Dermal Drug Delivery', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/02/20/93', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'restricted', 'lastmod_minute' => '39', 'refereed' => 'TRUE', 'contact_email' => 'b.r.conway@hud.ac.uk', 'copyright_holders' => undef, 'date_day' => undef, 'gscholar_impact' => undef, 'official_url' => 'http://www.sciepub.com/portal/downloads?doi=10.12691/ajps-2-5A-1&filename=ajps-2-5A-1.pdf', 'succeeds' => undef, 'datestamp_month' => '10', 'commentary' => undef, 'lastmod_day' => '16', 'publisher' => 'Science and Education Publishing', 'pagerange' => undef, 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2014', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'American Journal of Pharmacological Sciences', 'lastmod_second' => '11', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => undef, 'datestamp_hour' => '11', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '11', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 10, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '22093', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2014', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '10', 'event_dates' => undef, 'fulltimestamp' => '20141000', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '11', 'number' => '5A', 'rev_number' => '8', 'edit_lock_user' => '6', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '0', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'QD', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '39', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '16', 'datestamp_day' => '16', 'abstract' => 'Solid lipid nanoparticles (SLNs) have attracted increasing attention during recent years. Due to their unique size dependent properties, lipid nanoparticles offer possibilities to develop new therapeutics. The ability to incorporate drugs into nanoparticles offers a new prototype in drug delivery thus realizing the dual goal of both controlled release and site-specific drug delivery. Drug delivery to the skin is widely used for local and systemic delivery and has potential to be improved by application of nanoparticulate formulations. If investigated appropriately, solid lipid nanoparticles may open new opportunities in therapy of complex diseases which is difficult to treat.', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '6', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '39', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => '10.12691/ajps-2-5A-1', 'volume' => '2', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2014', 'status_changed_hour' => '11', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '8963' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1288956688', 'creatorlist' => { '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Alpar', 'eprintid' => '8963', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'H.O.', 'creators_id' => undef }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '8963', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '11', 'editors_name_honourific' => undef, 'admin_note' => undef, 'event_title' => undef, 'date_type' => 'published', 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2010', 'fileinfo' => '', 'status_changed_second' => '10', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'Co-encapsulation of proteins into PLA microspheres', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/00/89/63', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'none', 'lastmod_minute' => '38', 'refereed' => 'FALSE', 'contact_email' => undef, 'copyright_holders' => undef, 'date_day' => undef, 'gscholar_impact' => undef, 'official_url' => undef, 'succeeds' => undef, 'datestamp_month' => '11', 'commentary' => undef, 'lastmod_day' => '5', 'publisher' => 'Pharmaceutical Press', 'pagerange' => '173-176', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2010', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'Pharmaceutical sciences', 'lastmod_second' => '10', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '1460-8081', 'datestamp_hour' => '11', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '10', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 4, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '8963', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2010', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '11', 'event_dates' => undef, 'fulltimestamp' => '19960400', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '11', 'number' => '4', 'rev_number' => '6', 'edit_lock_user' => '3483', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '0', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'Q1', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '38', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '5', 'datestamp_day' => '5', 'abstract' => undef, 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '3483', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '38', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => undef, 'volume' => '2', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '1996', 'status_changed_hour' => '11', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '8847' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1317112710', 'creatorlist' => { '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '8847', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' }, '4' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Elliott', 'eprintid' => '8847', 'creators_name_honourific' => '', 'pos' => '4', 'creators_name_given' => 'T.S.J.', 'creators_id' => undef }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Karpanen', 'eprintid' => '8847', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'T.J.', 'creators_id' => undef }, '3' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Hilton', 'eprintid' => '8847', 'creators_name_honourific' => '', 'pos' => '3', 'creators_name_given' => 'A.C.', 'creators_id' => undef }, '2' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Worthington', 'eprintid' => '8847', 'creators_name_honourific' => '', 'pos' => '2', 'creators_name_given' => 'T.', 'creators_id' => undef }, '5' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Lambert', 'eprintid' => '8847', 'creators_name_honourific' => '', 'pos' => '5', 'creators_name_given' => 'P.A.', 'creators_id' => undef } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '10', 'editors_name_honourific' => undef, 'admin_note' => undef, 'event_title' => undef, 'date_type' => 'published', 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2010', 'fileinfo' => '/style/images/fileicons/application_pdf.png;/8847/1/1471%2D2334%2D10%2D278.pdf', 'status_changed_second' => '53', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'Enhanced chlorhexidine skin penetration with eucalyptus oil', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/00/88/47', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'public', 'lastmod_minute' => '38', 'refereed' => 'TRUE', 'contact_email' => undef, 'copyright_holders' => undef, 'date_day' => undef, 'gscholar_impact' => undef, 'official_url' => 'http://www.biomedcentral.com/1471-2334/10/278', 'succeeds' => undef, 'datestamp_month' => '10', 'commentary' => undef, 'lastmod_day' => '27', 'publisher' => 'Biomed Central', 'pagerange' => '1-6', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2010', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'BMC Infectious Diseases', 'lastmod_second' => '55', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '1471-2334', 'datestamp_hour' => '14', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '53', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 9, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '8847', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2011', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '9', 'event_dates' => undef, 'fulltimestamp' => '20100900', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '8', 'number' => '278', 'rev_number' => '11', 'edit_lock_user' => '3483', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '0', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'Q1', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '38', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '15', 'datestamp_day' => '15', 'abstract' => 'Background Chlorhexidine digluconate (CHG) is a widely used skin antiseptic, however it poorly penetrates the skin, limiting its efficacy against microorganisms residing beneath the surface layers of skin. The aim of the current study was to improve the delivery of chlorhexidine digluconate (CHG) when used as a skin antiseptic. Method Chlorhexidine was applied to the surface of donor skin and its penetration and retention under different conditions was evaluated. Skin penetration studies were performed on full-thickness donor human skin using a Franz diffusion cell system. Skin was exposed to 2% (w/v) CHG in various concentrations of eucalyptus oil (EO) and 70% (v/v) isopropyl alcohol (IPA). The concentration of CHG (?g/mg of skin) was determined to a skin depth of 1500 ?m by high performance liquid chromatography (HPLC). Results The 2% (w/v) CHG penetration into the lower layers of skin was significantly enhanced in the presence of EO. Ten percent (v/v) EO in combination with 2% (w/v) CHG in 70% (v/v) IPA significantly increased the amount of CHG which penetrated into the skin within 2 min. Conclusion The delivery of CHG into the epidermis and dermis can be enhanced by combination with EO, which in turn may improve biocide contact with additional microorganisms present in the skin, thereby enhancing antisepsis.', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '3494', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '38', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => '10.1186/1471-2334-10-278', 'volume' => '10', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2010', 'status_changed_hour' => '14', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '10144' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => 'Ibuprofen, swelling, erosion, drug release, release profile, controlled delivery', 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1302795326', 'creatorlist' => { '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '10144', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Nep', 'eprintid' => '10144', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'E.I.', 'creators_id' => undef } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '4', 'editors_name_honourific' => undef, 'admin_note' => undef, 'event_title' => undef, 'date_type' => 'published', 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2011', 'fileinfo' => '/style/images/fileicons/application_pdf.png;/10144/1/conwayGrewiapdf.pdf', 'status_changed_second' => '46', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'Grewia polysaccharide as a pharmaceutical excipient in matrix tablets', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/01/01/44', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'public', 'lastmod_minute' => '43', 'refereed' => 'TRUE', 'contact_email' => undef, 'copyright_holders' => undef, 'date_day' => undef, 'gscholar_impact' => undef, 'official_url' => 'http://ojs.abo.fi/index.php/jefc/article/view/46/53', 'succeeds' => undef, 'datestamp_month' => '4', 'commentary' => undef, 'lastmod_day' => '14', 'publisher' => 'International Pharmaceutical Excipients Council', 'pagerange' => '3-15', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2011', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'Journal of Excipients and Food Chemicals', 'lastmod_second' => '46', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '2150-2668', 'datestamp_hour' => '15', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '46', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 1, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '10144', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2011', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '4', 'event_dates' => undef, 'fulltimestamp' => '20110100', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '15', 'number' => '1', 'rev_number' => '7', 'edit_lock_user' => '6', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '0', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'Q1', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '43', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '14', 'datestamp_day' => '14', 'abstract' => 'Matrix-based tablets using different concentrations of grewia gum, and the model drug ibuprofen, were prepared using a wet granulation technique. Similar formulations were also prepared using HPMC, guar gum or ethyl cellulose as the polymer matrix. In addition to tablet properties, swelling and erosion of tablets and kinetics of drug release were also investigated. In vitro drug release studies, in phosphate buffer (pH 7.2) using USP type II apparatus, revealed that grewia gum at concentrations of 16%, 32% and 48% can sustain the release of ibuprofen tablets for up to 24 hours. Release profiles were similar to those tablets containing ethyl cellulose as the matrix former. Swelling and erosion of grewia gum matrices occurred simultaneously, and ibuprofen release was by anomalous diffusion in accordance with the Korsmeyer-Peppas model. There was evidence suggesting synergism between grewia gum and guar gum in sustaining the release of ibuprofen from tablets when used in the ratio 2:1. Grewia gum may therefore prove a useful excipient, when used on its own, or in combination with other polymers, to modify drug release', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '6', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '43', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => undef, 'volume' => '2', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2011', 'status_changed_hour' => '15', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '20899' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1403509698', 'creatorlist' => { '6' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Laity', 'eprintid' => '20899', 'creators_name_honourific' => '', 'pos' => '6', 'creators_name_given' => 'Peter R.', 'creators_id' => 'p.laity@hud.ac.uk' }, '3' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Rajabi-Siahboomi', 'eprintid' => '20899', 'creators_name_honourific' => '', 'pos' => '3', 'creators_name_given' => 'Ali R.', 'creators_id' => undef }, '7' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '20899', 'creators_name_honourific' => '', 'pos' => '7', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' }, '2' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Levina', 'eprintid' => '20899', 'creators_name_honourific' => '', 'pos' => '2', 'creators_name_given' => 'Marina', 'creators_id' => undef }, '8' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Nokhodchi', 'eprintid' => '20899', 'creators_name_honourific' => '', 'pos' => '8', 'creators_name_given' => 'Ali', 'creators_id' => undef }, '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Kaialy', 'eprintid' => '20899', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'Waseem', 'creators_id' => undef }, '4' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Ghori', 'eprintid' => '20899', 'creators_name_honourific' => '', 'pos' => '4', 'creators_name_given' => 'Mohammed U.', 'creators_id' => undef }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Asare-Addo', 'eprintid' => '20899', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'Kofi', 'creators_id' => 'k.asare-addo@hud.ac.uk' }, '5' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Šupuk', 'eprintid' => '20899', 'creators_name_honourific' => '', 'pos' => '5', 'creators_name_given' => 'Enes', 'creators_id' => 'e.supuk@hud.ac.uk' } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '6', 'editors_name_honourific' => undef, 'admin_note' => undef, 'event_title' => undef, 'date_type' => 'published', 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2014', 'fileinfo' => '', 'status_changed_second' => '37', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'The influence of agitation sequence and ionic strength on in vitro drug release from hypromellose (E4M and K4M) ER matrices--the use of the USP III apparatus.', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/02/08/99', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'none', 'lastmod_minute' => '52', 'refereed' => 'TRUE', 'contact_email' => undef, 'copyright_holders' => undef, 'date_day' => 1, 'gscholar_impact' => undef, 'official_url' => 'http://dx.doi.org/10.1016/j.colsurfb.2012.11.020', 'succeeds' => undef, 'datestamp_month' => '6', 'commentary' => undef, 'lastmod_day' => '23', 'publisher' => 'Elsevier', 'pagerange' => '54-60', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2014', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'Colloids and Surfaces B: Biointerfaces', 'lastmod_second' => '38', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '0927-7765', 'datestamp_hour' => '7', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '38', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 4, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '20899', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2014', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '6', 'event_dates' => undef, 'fulltimestamp' => '20130401', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '7', 'number' => undef, 'rev_number' => '7', 'edit_lock_user' => '3494', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '0', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'RS', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '52', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '23', 'datestamp_day' => '23', 'abstract' => 'Theophylline extended release (ER) matrices containing hypromellose (hydroxypropyl methylcellulose (HPMC) E4M and K4M were evaluated in media with a pH range of 1.2-7.5, using an automated USP type III, Bio-Dis dissolution apparatus. The objectives of this study were to evaluate the effects of systematic agitation, ionic strength and pH on the release of theophylline from the gel forming hydrophilic polymeric matrices with different methoxyl substitution levels. Tribo-electric charging of hypromellose, theophylline and their formulated blends containing E4M and K4M grades has been characterised, along with quantitative observations of flow, compression behaviour and particle morphology. Agitations were studied at 5, 10, 15, 20, 25, 30 dips per minute (dpm) and also in the ascending and descending order in the dissolution vials. The ionic concentration strength of the media was also varied over a range of 0-0.4M to simulate the gastrointestinal fed and fasted states and various physiological pH conditions. To study the effect of ionic strength on the hydrophilic matrices, agitation was set at 20 dpm. The charge results on individual components imply that the positively charged particles have coupled with the negatively charged particles to form a stable ordered mixture which is believed to result in a more homogeneous and stable system. The particle shape analysis showed the HPMC K4M polymer to have a more irregular morphology and a rougher surface texture in comparison to the HPMC E4M polymer, possibly a contributory factor to the gelation process. The results showed gelation occurred quicker for the K4M tablet matrices. Drug release increased with increased agitation. This was more pronounced for the E4M tablet matrices. The ionic strength also had more of an effect on the drug release from the E4M matrices. The experiments highlighted the resilience of the K4M matrices in comparison with the E4M matrices. The results thus show that despite similar viscosities of E4M and K4M, the methoxyl substitution makes a difference to their control of drug release and as such care and consideration should be given to the choice of polymer used for extended release. The use of systematic change of agitation method and ionic strength may indicate potential fed and fasted effects on drug release from hydrophilic matrices.', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '21377', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '52', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => '10.1016/j.colsurfb.2012.11.020', 'volume' => '104', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2013', 'status_changed_hour' => '7', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '8931' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1288866503', 'creatorlist' => { '4' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Lambert', 'eprintid' => '8931', 'creators_name_honourific' => '', 'pos' => '4', 'creators_name_given' => 'P. A.', 'creators_id' => undef }, '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Worthington', 'eprintid' => '8931', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'T.', 'creators_id' => undef }, '3' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '8931', 'creators_name_honourific' => '', 'pos' => '3', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Karpanen', 'eprintid' => '8931', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'T. J.', 'creators_id' => undef }, '2' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Hendry', 'eprintid' => '8931', 'creators_name_honourific' => '', 'pos' => '2', 'creators_name_given' => 'E. R.', 'creators_id' => undef } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '11', 'editors_name_honourific' => undef, 'admin_note' => undef, 'event_title' => undef, 'date_type' => 'published', 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2010', 'fileinfo' => '', 'status_changed_second' => '38', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'Antimicrobial efficacy of chlorhexidine digluconate alone and in combination with eucalyptus oil, tea tree oil and thymol against planktonic and biofilm cultures of Staphylococcus epidermidis', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/00/89/31', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'none', 'lastmod_minute' => '32', 'refereed' => 'TRUE', 'contact_email' => undef, 'copyright_holders' => undef, 'date_day' => undef, 'gscholar_impact' => undef, 'official_url' => 'http://dx.doi.org/10.1093/jac/dkn325', 'succeeds' => undef, 'datestamp_month' => '11', 'commentary' => undef, 'lastmod_day' => '4', 'publisher' => 'Oxford University Press', 'pagerange' => '1031-1036', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2010', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'Journal of Antimicrobial Chemotherapy', 'lastmod_second' => '38', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '0305-7453', 'datestamp_hour' => '10', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '38', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 11, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '8931', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2010', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '11', 'event_dates' => undef, 'fulltimestamp' => '20081100', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '10', 'number' => '5', 'rev_number' => '8', 'edit_lock_user' => '3483', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '1', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'R1', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '32', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '4', 'datestamp_day' => '4', 'abstract' => 'Objectives Effective skin antisepsis and disinfection of medical devices are key factors in preventing many healthcare-acquired infections associated with skin microorganisms, particularly Staphylococcus epidermidis. The aim of this study was to investigate the antimicrobial efficacy of chlorhexidine digluconate (CHG), a widely used antiseptic in clinical practice, alone and in combination with tea tree oil (TTO), eucalyptus oil (EO) and thymol against planktonic and biofilm cultures of S. epidermidis. Methods Antimicrobial susceptibility assays against S. epidermidis in a suspension and in a biofilm mode of growth were performed with broth microdilution and ATP bioluminescence methods, respectively. Synergy of antimicrobial agents was evaluated with the chequerboard method. Results CHG exhibited antimicrobial activity against S. epidermidis in both suspension and biofilm (MIC 2–8 mg/L). Of the essential oils thymol exhibited the greatest antimicrobial efficacy (0.5–4 g/L) against S. epidermidis in suspension and biofilm followed by TTO (2–16 g/L) and EO (4–64 g/L). MICs of CHG and EO were reduced against S. epidermidis biofilm when in combination (MIC of 8 reduced to 0.25–1 mg/L and MIC of 32–64 reduced to 4 g/L for CHG and EO, respectively). Furthermore, the combination of EO with CHG demonstrated synergistic activity against S. epidermidis biofilm with a fractional inhibitory concentration index of <0.5. Conclusions The results from this study suggest that there may be a role for essential oils, in particular EO, for improved skin antisepsis when combined with CHG. ', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '3483', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '32', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => 'doi:10.1093/jac/dkn325', 'volume' => '62', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2008', 'status_changed_hour' => '10', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '8930' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1405509313', 'creatorlist' => { '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Worthington', 'eprintid' => '8930', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'T.', 'creators_id' => undef }, '4' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Elliott', 'eprintid' => '8930', 'creators_name_honourific' => '', 'pos' => '4', 'creators_name_given' => 'T. S. J.', 'creators_id' => undef }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Karpanen', 'eprintid' => '8930', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'T. J.', 'creators_id' => undef }, '3' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Hilton', 'eprintid' => '8930', 'creators_name_honourific' => '', 'pos' => '3', 'creators_name_given' => 'A. C.', 'creators_id' => undef }, '2' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '8930', 'creators_name_honourific' => '', 'pos' => '2', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' }, '5' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Lambert', 'eprintid' => '8930', 'creators_name_honourific' => '', 'pos' => '5', 'creators_name_given' => 'P. A.', 'creators_id' => undef } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '11', 'editors_name_honourific' => undef, 'admin_note' => 'Published version ok to use re sherpa and gs 16/07/14', 'event_title' => undef, 'date_type' => 'published', 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2010', 'fileinfo' => '/style/images/fileicons/application_pdf.png;/8930/1/3633_full.pdf', 'status_changed_second' => '46', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'Penetration of Chlorhexidine into Human Skin', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/00/89/30', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'public', 'lastmod_minute' => '15', 'refereed' => 'TRUE', 'contact_email' => undef, 'copyright_holders' => undef, 'date_day' => undef, 'gscholar_impact' => undef, 'official_url' => 'http://dx.doi.org/10.1128/AAC.00637-08', 'succeeds' => undef, 'datestamp_month' => '11', 'commentary' => undef, 'lastmod_day' => '16', 'publisher' => 'American Society for Microbiology', 'pagerange' => '3633-3636', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2010', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'Antimicrobial Agents and Chemotherapy', 'lastmod_second' => '58', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '0066-4804', 'datestamp_hour' => '10', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '46', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 10, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '8930', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2014', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '7', 'event_dates' => undef, 'fulltimestamp' => '20081000', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '11', 'number' => '10', 'rev_number' => '10', 'edit_lock_user' => '3483', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '0', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'Q1', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '24', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '4', 'datestamp_day' => '4', 'abstract' => 'This study evaluated a model of skin permeation to determine the depth of delivery of chlorhexidine into full-thickness excised human skin following topical application of 2% (wt/vol) aqueous chlorhexidine digluconate. Skin permeation studies were performed on full-thickness human skin using Franz diffusion cells with exposure to chlorhexidine for 2 min, 30 min, and 24 h. The concentration of chlorhexidine extracted from skin sections was determined to a depth of 1,500 µm following serial sectioning of the skin using a microtome and analysis by high-performance liquid chromatography. Poor penetration of chlorhexidine into skin following 2-min and 30-min exposures to chlorhexidine was observed (0.157 ± 0.047 and 0.077 ± 0.015 µg/mg tissue within the top 100 µm), and levels of chlorhexidine were minimal at deeper skin depths (less than 0.002 µg/mg tissue below 300 µm). After 24 h of exposure, there was more chlorhexidine within the upper 100-µm sections (7.88 ± 1.37 µg/mg tissue); however, the levels remained low (less than 1 µg/mg tissue) at depths below 300 µm. There was no detectable penetration through the full-thickness skin. The model presented in this study can be used to assess the permeation of antiseptic agents through various layers of skin in vitro. Aqueous chlorhexidine demonstrated poor permeation into the deeper layers of the skin, which may restrict the efficacy of skin antisepsis with this agent. This study lays the foundation for further research in adopting alternative strategies for enhanced skin antisepsis in clinical practice. ', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '3483', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '24', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => 'doi:10.1128/AAC.00637-08', 'volume' => '52', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2008', 'status_changed_hour' => '10', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '11515' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1344586515', 'creatorlist' => { '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '11515', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Nep', 'eprintid' => '11515', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'Elijah I', 'creators_id' => undef } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '9', 'editors_name_honourific' => undef, 'admin_note' => undef, 'event_title' => undef, 'date_type' => 'published', 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2011', 'fileinfo' => '', 'status_changed_second' => '40', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'Preformulation studies on grewia gum as a formulation excipient', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/01/15/15', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'none', 'lastmod_minute' => '17', 'refereed' => 'TRUE', 'contact_email' => undef, 'copyright_holders' => undef, 'date_day' => undef, 'gscholar_impact' => undef, 'official_url' => 'http://dx.doi.org/10.1007/s10973-011-1782-4', 'succeeds' => undef, 'datestamp_month' => '9', 'commentary' => undef, 'lastmod_day' => '10', 'publisher' => 'Springer', 'pagerange' => '197-205', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2011', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'Journal of Thermal Analysis and Calorimetry', 'lastmod_second' => '29', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '1388-6150', 'datestamp_hour' => '11', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '40', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 4, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '11515', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2012', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '8', 'event_dates' => undef, 'fulltimestamp' => '20120400', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '8', 'number' => '1', 'rev_number' => '10', 'edit_lock_user' => '3494', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '0', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'Q1', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '23', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '20', 'datestamp_day' => '20', 'abstract' => 'Grewia gum is a naturally occurring polysaccharide which has potential as a pharmaceutical excipient. Differential scanning calorimetry and Fourier transform infrared (FT-IR) spectroscopy techniques were used to examine the thermal and molecular behaviours, respectively, of mixtures of grewia gum with cimetidine, ibuprofen or standard excipients, to assess potential interactions. No disappearance or broadening of the melting endotherm was seen with cimetidine or ibuprofen. Similarly, there was no interaction between grewia gum and the standard excipients tested. The results obtained using thermal analyses were supported by FT-IR analysis of the material mixtures. Grewia gum is an inert natural polymer which can be used alone or in combination with other excipients in the formulation of pharmaceutical dosage forms', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '6', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '23', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => 'doi:10.1007/s10973-011-1782-4', 'volume' => '108', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2012', 'status_changed_hour' => '11', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '17847' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1400662803', 'creatorlist' => { '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '17847', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Adebisi', 'eprintid' => '17847', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'Adeola O.', 'creators_id' => undef } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '7', 'editors_name_honourific' => undef, 'admin_note' => 'Emailed author for PP 2/7/13', 'event_title' => undef, 'date_type' => 'published', 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2013', 'fileinfo' => '', 'status_changed_second' => '44', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'Preparation and characterisation of gastroretentive alginate beads for targeting H. pylori', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/01/78/47', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'none', 'lastmod_minute' => '0', 'refereed' => 'TRUE', 'contact_email' => 'b.r.conway@hud.ac.uk', 'copyright_holders' => undef, 'date_day' => undef, 'gscholar_impact' => undef, 'official_url' => 'http://dx.doi.org/10.3109/02652048.2013.805840', 'succeeds' => undef, 'datestamp_month' => '7', 'commentary' => undef, 'lastmod_day' => '21', 'publisher' => 'Informa Healthcare', 'pagerange' => '58-67', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2013', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'Journal of Microencapsulation', 'lastmod_second' => '58', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '0265-2048', 'datestamp_hour' => '13', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '44', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 1, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '17847', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2014', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '5', 'event_dates' => undef, 'fulltimestamp' => '20140100', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '9', 'number' => '1', 'rev_number' => '10', 'edit_lock_user' => '3483', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '0', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'RS', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '12', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '2', 'datestamp_day' => '2', 'abstract' => 'There are various obstacles in the eradication of Helicobacter pylori (H. pylori) infections including low drug levels due to short gastric residence times and poor accessibility of the drug at the site of the infection. In this study, calcium alginate beads containing metronidazole were prepared by ionotropic gelation with diameters ranging from 2 to 3?mm and bulk densities ranging from 0.11 to 0.23?g/cm3. These beads failed buoyancy tests and released the drug rapidly. The formulation was modified in order to improve floating and modify their drug release profile through addition of oil and coating with chitosan. Upon modification, buoyancy improved and drug release was sustained. This novel formulation will ensure retention for a longer period in the stomach and control the release of drug, ensuring high local drug concentrations, leading to improved eradication of the bacteria. Read More: http://informahealthcare.com.libaccess.hud.ac.uk/doi/abs/10.3109/02652048.2013.805840', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '6307', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '12', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => 'doi:10.3109/02652048.2013.805840', 'volume' => '31', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2014', 'status_changed_hour' => '13', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '19778' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1405598427', 'creatorlist' => { '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Ginting', 'eprintid' => '19778', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'Gidion', 'creators_id' => undef }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Ghori', 'eprintid' => '19778', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'Muhammad U.', 'creators_id' => undef }, '3' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '19778', 'creators_name_honourific' => '', 'pos' => '3', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' }, '2' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Smith', 'eprintid' => '19778', 'creators_name_honourific' => '', 'pos' => '2', 'creators_name_given' => 'Alan M.', 'creators_id' => 'a.m.smith@hud.ac.uk' } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '3', 'editors_name_honourific' => undef, 'admin_note' => 'Emailed author for FT 6/3/14', 'event_title' => undef, 'date_type' => 'published', 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2014', 'fileinfo' => '/style/images/fileicons/application_pdf.png;/19778/1/conwayIJP_13903.pdf', 'status_changed_second' => '18', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'Simultaneous quantification of drug release and erosion from hypromellose hydrophilic matrices', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/01/97/78', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'public', 'lastmod_minute' => '1', 'refereed' => 'TRUE', 'contact_email' => 'b.r.conway@hud.ac.uk', 'copyright_holders' => undef, 'date_day' => undef, 'gscholar_impact' => undef, 'official_url' => 'http://dx.doi.org/10.1016/j.ijpharm.2014.02.028', 'succeeds' => undef, 'datestamp_month' => '3', 'commentary' => undef, 'lastmod_day' => '17', 'publisher' => 'Elsevier', 'pagerange' => '405-412', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2014', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'International Journal of Pharmaceutics', 'lastmod_second' => '22', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '0378-5173', 'datestamp_hour' => '15', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '18', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 4, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '19778', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2014', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '7', 'event_dates' => undef, 'fulltimestamp' => '20140400', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '12', 'number' => '1-2', 'rev_number' => '14', 'edit_lock_user' => '3483', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '0', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'R1', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '28', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '6', 'datestamp_day' => '6', 'abstract' => 'Hypromellose, HPMC, is frequently used to control drug release from matrix tablet formulations. Drug is released by a combination of diffusion through and erosion of, the matrix and is usually measured invitro by separate dissolution and swelling/erosion studies. The present study was designed to measure matrix erosion, polymer dissolution and drug release kinetics and their inter-relationship in a single experiment using a phenol-sulphuric acid assay to quantify dissolved HPMC alongside spectrophotometrical analysis of drug release. HPMC-based matrix tablets were manufactured containing two drugs at various drug:HPMC ratios. Drug release was determined and the degree of erosion was calculated by gravimetry. Results showed the matrix erosion rate and drug release were dependent on HPMC content and drug solubility, as expected. It was also apparent that the erosion rate was directly related to the drug release kinetics and comparative analysis of both matrix erosion techniques showed a high level of correlation. The findings show that a simple and inexpensive assay can be utilised not only to quantify HPMC but can also be used to calculate the degree of erosion of tablet matrices, negating the need for a separate study and providing a simplified practical approach that may be of use during product optimization.', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '6', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '28', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => 'doi:10.1016/j.ijpharm.2014.02.028', 'volume' => '465', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2014', 'status_changed_hour' => '15', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '11736' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1318934820', 'creatorlist' => { '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '11736', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Nep', 'eprintid' => '11736', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'Elijah I', 'creators_id' => undef } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '10', 'editors_name_honourific' => undef, 'admin_note' => 'Emailed permission SJT 18/10/11', 'event_title' => undef, 'date_type' => 'published', 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2011', 'fileinfo' => '/style/images/fileicons/application_pdf.png;/11736/1/ConwayGrewia2.pdf', 'status_changed_second' => '7', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'Grewia Gum 2: Mucoadhesive Properties of Compacts and Gels', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/01/17/36', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'restricted', 'lastmod_minute' => '54', 'refereed' => 'TRUE', 'contact_email' => undef, 'copyright_holders' => undef, 'date_day' => undef, 'gscholar_impact' => undef, 'official_url' => 'http://dx.doi.org/10.4314/tjpr.v10i4.4', 'succeeds' => undef, 'datestamp_month' => '10', 'commentary' => undef, 'lastmod_day' => '18', 'publisher' => 'Pharmacotherapy Group', 'pagerange' => '393-401', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2011', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'Tropical Journal of Pharmaceutical Research', 'lastmod_second' => '7', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '1596-5996', 'datestamp_hour' => '10', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '7', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 8, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '11736', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2011', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '10', 'event_dates' => undef, 'fulltimestamp' => '20110800', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '10', 'number' => '4', 'rev_number' => '8', 'edit_lock_user' => '6', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '0', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'Q1', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '54', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => '718', 'status_changed_day' => '18', 'datestamp_day' => '18', 'abstract' => 'Purpose: To compare the mucoadhesive performance of grewia polysaccharide gum with those of guar gum, carboxymethylcellulose, hydroxypropyl methylcellulose and carbopol 971P. Methods: Grewia polysaccharide gum compacts or gels as well as those of guar gum, carboxymethylcellulose, hydroxypropyl methylcellulose or carbopol 971P were prepared. Texturometric and tensile analysis of the polymer gels and compacts were carried out using a software-controlled penetrometre, TA.XTPlus texture analyzer. The polymer gels were evaluated for hardness, stickiness, work of cohesion and work of adhesion. Furthermore, the detachment force of the polymer compacts from a mucin substrate was evaluated. Results: The work of adhesion of guar gels was significantly greater than that of grewia gels (p < 0.001) but the latter showed a significantly greater work of adhesion than carboxymethylcellulose gels (p < 0.05) and hydroxypropyl methylcellulose gels (p < 0.001). However, the work of cohesion for grewia/mucin gel mixture was significantly greater (p < 0.001) than those of carboxymethylcellulose/mucin, hydroxypropyl methylcellulose/mucin and carbopol 971P/mucin gel blends. The difference between the mucoadhesive performance of grewia compacts and those of hydroxypropyl methylcellulose and carbopol 971P compacts was insignificant (p > 0.05). Conclusion: Grewia polysaccharide gum demonstrated good mucoadhesive properties, comparable to those of carbopol 971P, carboxymethylcellulose, guar gum and hydroxypropyl methylcellulose, and therefore, should be suitable for the formulation of retentive drug delivery devices.', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '6', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '54', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => 'doi:10.4314/tjpr.v10i4.4', 'volume' => '10', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2011', 'status_changed_hour' => '10', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '10343' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1305041954', 'creatorlist' => { '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Ramirez', 'eprintid' => '10343', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'M.', 'creators_id' => undef }, '4' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Coles', 'eprintid' => '10343', 'creators_name_honourific' => '', 'pos' => '4', 'creators_name_given' => 'S.J.', 'creators_id' => undef }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Schwalbe', 'eprintid' => '10343', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'C.H.', 'creators_id' => undef }, '3' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Bache', 'eprintid' => '10343', 'creators_name_honourific' => '', 'pos' => '3', 'creators_name_given' => 'C.J.', 'creators_id' => undef }, '2' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '10343', 'creators_name_honourific' => '', 'pos' => '2', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' }, '5' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Timmins', 'eprintid' => '10343', 'creators_name_honourific' => '', 'pos' => '5', 'creators_name_given' => 'P.', 'creators_id' => undef } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '5', 'editors_name_honourific' => undef, 'admin_note' => 'Emailed permission SJT 10/5/11', 'event_title' => 'American Crystallographic Association 2010 Annual Meeting', 'date_type' => 'published', 'pres_type' => 'paper', 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2011', 'fileinfo' => '/style/images/fileicons/application_pdf.png;/10343/1/ConwayStructure.pdf', 'status_changed_second' => '8', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'Structure and properties of (hydroxy)alkylammonium salts of flurbiprofen', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/01/03/43', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'public', 'lastmod_minute' => '39', 'refereed' => undef, 'contact_email' => undef, 'copyright_holders' => undef, 'date_day' => undef, 'gscholar_impact' => undef, 'official_url' => 'http://www.amercrystalassn.org/documents/2010Transactions/Schwalbe_C.pdf', 'succeeds' => '8585', 'datestamp_month' => '5', 'commentary' => undef, 'lastmod_day' => '10', 'publisher' => 'American Crystallographic Association', 'pagerange' => undef, 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2011', 'book_title' => 'Transactions of the Symposium held at the 2010 American Crystallographic Association Annual Meeting', 'thesis_name' => undef, 'event_location' => 'Chicago, Illinois', 'type' => 'book_section', 'publication' => 'Transactions of the American Crystallographic Association', 'lastmod_second' => '24', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '0065-8006', 'datestamp_hour' => '11', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '8', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 7, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '10343', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2011', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '5', 'event_dates' => '24th-29th July 2010', 'fulltimestamp' => '20100700', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '15', 'number' => undef, 'rev_number' => '10', 'edit_lock_user' => '6', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '0', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'Q1', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '19', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => 'other', 'importid' => undef, 'status_changed_day' => '10', 'datestamp_day' => '10', 'abstract' => 'Interactions with hydrogen atoms strongly affect the structure of salts of the anti-inflammatory drug flurbiprofen. With cations of the form H3N+C(CH3)3-n(CH2OH)n for n = 0-3 charge-assisted hydrogen bonding is the most obvious feature. In the t-butylammonium (n = 0) salt successive R43(10) rings are formed by +N-H…OCO- interactions. With n = 1 the additional OH is disordered and has little effect. However, n = 2 changes the pattern: now one +N-H…OCO- and one O-H…OCO- hydrogen bond link a cation to a carboxylate anion. When n = 3, this motif persists in one polymorph. However, another polymorph has two independent anions related by pseudo-translation and two independent cations related by a pseudo-glide, while extensive disorder results from application of the “opposite” pseudo-symmetry operation. Enantiomer discrimination at flurbiprofen sites depends on the environment of H and CH3 in the HCCH3 group. Hirshfeld surfaces show normal van der Waals contacts around ordered methyl groups but tight contacts around major sites for disordered ones, which become worse around the minor sites. Similar effects are observed in the vicinity of the fluorine atoms in the fluorophenyl rings. Whereas the major sites for disordered atoms and the sites for ordered atoms are involved in normal or slightly short van der Waals contacts, the minor sites suffer from tighter contacts. 2.', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '6', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '19', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => undef, 'volume' => undef, 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2010', 'status_changed_hour' => '11', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '8932' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1288866979', 'creatorlist' => { '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '8932', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '11', 'editors_name_honourific' => undef, 'admin_note' => undef, 'event_title' => undef, 'date_type' => 'published', 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2010', 'fileinfo' => '', 'status_changed_second' => '58', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'Delivering scents and flavours - lessons from the pharmaceutical industry ', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/00/89/32', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'none', 'lastmod_minute' => '40', 'refereed' => 'TRUE', 'contact_email' => undef, 'copyright_holders' => undef, 'date_day' => undef, 'gscholar_impact' => undef, 'official_url' => 'http://chemistry-today.teknoscienze.com/testata.asp?id_testata=134&folder=backissue', 'succeeds' => undef, 'datestamp_month' => '11', 'commentary' => undef, 'lastmod_day' => '4', 'publisher' => 'Tekno Scienze', 'pagerange' => '28-29', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2010', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'Chimica Oggi', 'lastmod_second' => '58', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '0392-839X', 'datestamp_hour' => '10', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '58', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 5, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '8932', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2010', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '11', 'event_dates' => undef, 'fulltimestamp' => '20080500', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '10', 'number' => '3', 'rev_number' => '6', 'edit_lock_user' => '3483', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '1', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'QD', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '40', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '4', 'datestamp_day' => '4', 'abstract' => undef, 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '3483', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '40', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => undef, 'volume' => '26', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2008', 'status_changed_hour' => '10', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '17607' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1381328988', 'creatorlist' => { '4' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Nokhodchi', 'eprintid' => '17607', 'creators_name_honourific' => '', 'pos' => '4', 'creators_name_given' => 'Ali', 'creators_id' => undef }, '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '17607', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Asare-Addo', 'eprintid' => '17607', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'Kofi', 'creators_id' => 'k.asare-addo@hud.ac.uk' }, '3' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Kaialy', 'eprintid' => '17607', 'creators_name_honourific' => '', 'pos' => '3', 'creators_name_given' => 'Waseem', 'creators_id' => undef }, '2' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Hajamohaideen', 'eprintid' => '17607', 'creators_name_honourific' => '', 'pos' => '2', 'creators_name_given' => 'Mohamed J.', 'creators_id' => undef }, '5' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Larhrib', 'eprintid' => '17607', 'creators_name_honourific' => '', 'pos' => '5', 'creators_name_given' => 'El Hassan', 'creators_id' => 'e.larhrib@hud.ac.uk' } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '5', 'editors_name_honourific' => undef, 'admin_note' => undef, 'event_title' => undef, 'date_type' => 'published', 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2013', 'fileinfo' => '', 'status_changed_second' => '48', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'Aqueous And Hydro-Alcoholic Media Effects On Polyols', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/01/76/07', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'none', 'lastmod_minute' => '29', 'refereed' => 'TRUE', 'contact_email' => undef, 'copyright_holders' => undef, 'date_day' => undef, 'gscholar_impact' => undef, 'official_url' => 'http://dx.doi.org/10.1016/j.colsurfb.2013.05.003', 'succeeds' => undef, 'datestamp_month' => '5', 'commentary' => undef, 'lastmod_day' => '9', 'publisher' => 'Elsevier', 'pagerange' => '24-29', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2013', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'Colloids and Surfaces B: Biointerfaces', 'lastmod_second' => '54', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '0927-7765', 'datestamp_hour' => '13', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '48', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 11, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '17607', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2013', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '10', 'event_dates' => undef, 'fulltimestamp' => '20131100', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '14', 'number' => undef, 'rev_number' => '10', 'edit_lock_user' => '116', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '0', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'RS', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '23', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '16', 'datestamp_day' => '16', 'abstract' => 'The ingestion of drug products with alcohol can have an adverse effect on drug levels in a patient's blood. The Food and Drug Agency (FDA) issued an alert in 2005 after hydromorphone was withdrawn from the market after clinical trials showed ingestion with alcohol to potentially result in lethal drug peak plasma concentrations. The potential impact of alcohol on extended release (ER) tablet matrices and the need to develop ER matrices robust to alcohol effects has then been of interest. This study investigated the compaction properties of polyols and their effect on drug release. Polyols (erythritol, xylitol, mannitol and maltitol) with increasing hydroxyl groups were used as diluents for HPMC matrices containing theophylline. Release profiles were determined in pH 1.2 and 6.8 dissolution media with hydro-alcoholic concentrations of 5-40%. Increases in the polyols’ hydroxyl groups brought about an increase in tablet strength and a decrease in the drug release rates. This is likely due to stronger bond formation with increasing hydroxyls. The impact of alcohol on drug release was studied further for maltitol formulations. Maltitol was resilient to the presence of ethanol (5-40% v/v) at pH 1.2 (f2 = 57-74) but not at pH 6.8 (f2 = 36-48). Drug release was not different above 5% alcohol concentration at pH 6.8. The results of this in vitro study suggest that ethanol concentrations as high as 40% do not substantially alter the drug release properties of theophylline from maltitol matrix tablets. However care and consideration should be given to choice of polyol or mixture of polyols in obtaining a desired drug release profile.', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '116', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '23', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => 'doi:10.1016/j.colsurfb.2013.05.003', 'volume' => '111', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2013', 'status_changed_hour' => '13', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '8959' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1288950769', 'creatorlist' => { '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Alpar', 'eprintid' => '8959', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'H.O.', 'creators_id' => undef }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Eyles', 'eprintid' => '8959', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'J.E.', 'creators_id' => undef }, '3' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Keswick', 'eprintid' => '8959', 'creators_name_honourific' => '', 'pos' => '3', 'creators_name_given' => 'M.', 'creators_id' => undef }, '2' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '8959', 'creators_name_honourific' => '', 'pos' => '2', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '11', 'editors_name_honourific' => undef, 'admin_note' => undef, 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'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '12', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 5, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '8948', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2010', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '11', 'event_dates' => undef, 'fulltimestamp' => '20040500', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '14', 'number' => '2', 'rev_number' => '7', 'edit_lock_user' => '3483', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '1', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'QD', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '5', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '4', 'datestamp_day' => '4', 'abstract' => 'Release of nicotine from conventional gums and from gums made using a directly compressible gum base was studied using the European Pharmacopoeia apparatus for testing of medicated chewing gums. It was found that gum base and the method of preparation used in a formulation were important factors when controlling the release of drugs from chewing gum.', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '3483', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '5', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => undef, 'volume' => '11', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2004', 'status_changed_hour' => '14', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '8511' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1342613251', 'creatorlist' => { '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Ramirez', 'eprintid' => '8511', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'Miren', 'creators_id' => undef }, '3' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '8511', 'creators_name_honourific' => '', 'pos' => '3', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'David', 'eprintid' => '8511', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'Sarah E.', 'creators_id' => undef }, '2' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Timmins', 'eprintid' => '8511', 'creators_name_honourific' => '', 'pos' => '2', 'creators_name_given' => 'Peter', 'creators_id' => undef } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '9', 'editors_name_honourific' => undef, 'admin_note' => undef, 'event_title' => undef, 'date_type' => 'published', 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2010', 'fileinfo' => '', 'status_changed_second' => '17', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'Comparative physical, mechanical and crystallographic properties of a series of gemfibrozil salts', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/00/85/11', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'none', 'lastmod_minute' => '8', 'refereed' => 'TRUE', 'contact_email' => 'b.r.conway@hud.ac.uk', 'copyright_holders' => undef, 'date_day' => undef, 'gscholar_impact' => undef, 'official_url' => 'http://dx.doi.org/10.1111/j.2042-7158.2010.01025.x', 'succeeds' => undef, 'datestamp_month' => '9', 'commentary' => undef, 'lastmod_day' => '18', 'publisher' => 'John Wiley & Sons ', 'pagerange' => '1519-1525', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2010', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'Journal of Pharmacy and Pharmacology', 'lastmod_second' => '28', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '2042-7158', 'datestamp_hour' => '11', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '17', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 11, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '8511', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2012', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '7', 'event_dates' => undef, 'fulltimestamp' => '20101100', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '12', 'number' => '11', 'rev_number' => '10', 'edit_lock_user' => '3483', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '1', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'RM', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '51', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '10', 'datestamp_day' => '10', 'abstract' => 'Objectives? Understanding the impact of the counterion on the properties of an acidic or basic drug may influence the choice of salt form, especially for less potent drugs with a high drug load per unit dose. The aim of this work was to determine the influence of the hydrogen bonding potential of the counterion on the crystal structure of salts of the poorly soluble, poorly compressible, acidic drug gemfibrozil and to correlate these with mechanical properties. Methods? Compacts of the parent drug and the salts were used to determine Young's modulus of elasticity using beam bending tests. Crystal structures were determined previously from X-ray powder diffraction data. Key findings? The free acid, tert-butylamine, 2-amino-2-methylpropan-1-ol and 2-amino-2-methylpropan-1,3-diol salts had a common crystal packing motif of infinite hydrogen-bonded chains with cross-linking between pairs of adjacent chains. The tromethamine (trsi) salt, with different mechanical properties, had a two-dimensional sheet-like network of hydrogen bonds, with slip planes, forming a stiffer compact. Conclusions? The type of counter ion is important in determining mechanical properties and could be selected to afford slip and plastic deformation ', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '3483', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '51', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => 'doi:10.1111/j.2042-7158.2010.01025.x', 'volume' => '62', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2010', 'status_changed_hour' => '11', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '11514' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1318948545', 'creatorlist' => { '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Casey', 'eprintid' => '11514', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'A. L.', 'creators_id' => undef }, '4' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Elliott', 'eprintid' => '11514', 'creators_name_honourific' => '', 'pos' => '4', 'creators_name_given' => 'T. S. J.', 'creators_id' => undef }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Karpanen', 'eprintid' => '11514', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'T. J.', 'creators_id' => undef }, '3' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Lambert', 'eprintid' => '11514', 'creators_name_honourific' => '', 'pos' => '3', 'creators_name_given' => 'P. A.', 'creators_id' => undef }, '2' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '11514', 'creators_name_honourific' => '', 'pos' => '2', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '9', 'editors_name_honourific' => undef, 'admin_note' => 'Emailed author for PP SJT 20/9/11 Author does not have a copy 20/9/11', 'event_title' => undef, 'date_type' => 'published', 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2011', 'fileinfo' => '', 'status_changed_second' => '0', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'Antimicrobial activity of a chlorhexidine intravascular catheter site gel dressing', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/01/15/14', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'none', 'lastmod_minute' => '36', 'refereed' => 'TRUE', 'contact_email' => undef, 'copyright_holders' => undef, 'date_day' => undef, 'gscholar_impact' => undef, 'official_url' => 'http://dx.doi.org/10.1093/jac/dkr191', 'succeeds' => undef, 'datestamp_month' => '9', 'commentary' => undef, 'lastmod_day' => '18', 'publisher' => 'Oxford University Press', 'pagerange' => '1777-1784', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2011', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'Journal of Antimicrobial Chemotherapy', 'lastmod_second' => '20', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '0305-7453', 'datestamp_hour' => '11', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '0', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 8, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '11514', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2011', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '10', 'event_dates' => undef, 'fulltimestamp' => '20110800', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '14', 'number' => '8', 'rev_number' => '9', 'edit_lock_user' => '6', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '0', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'Q1', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '17', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '20', 'datestamp_day' => '20', 'abstract' => 'Objectives The antimicrobial efficacy of a chlorhexidine gluconate (CHG) intravascular catheter gel dressing was evaluated against methicillin-resistant Staphylococcus aureus (MRSA) and an extended-spectrum ?-lactamase (ESBL)-producing Escherichia coli. Chlorhexidine deposition on the skin surface and release from the gel were determined. Methods The antimicrobial efficacy was evaluated in in vitro studies following microbial inoculation of the dressing and application of the dressing on the inoculated surface of a silicone membrane and donor skin [with and without a catheter segment and/or 10% (v/v) serum] on diffusion cells. Antimicrobial activity was evaluated for up to 7 days. Chlorhexidine skin surface deposition and release were also determined. Results MRSA and E. coli were not detectable within 5 min following direct inoculation onto the CHG gel dressing. On the silicone membrane, 3 log and 6 log inocula of MRSA were eradicated within 5 min and 1 h, respectively. Time to kill was prolonged in the presence of serum and a catheter segment. Following inoculation of donor skin with 6 log cfu of MRSA, none was detected after 24 h. Chlorhexidine was released from the gel after a lag time of 30 min and increasing amounts were detected on the donor skin surface over the 48 h test period. The CHG gel dressing retained its antimicrobial activity on the artificial skin for 7 days. Conclusions The CHG intravascular catheter site gel dressing had detectable antimicrobial activity for up to 7 days, which should suppress bacterial growth on the skin at the catheter insertion site, thereby reducing the risk of infection. ', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '6', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '17', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => 'doi:10.1093/jac/dkr191', 'volume' => '66', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2011', 'status_changed_hour' => '11', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '10143' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => 'Grewia gum, cimetidine, matrix tablets, controlled delivery.', 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1302794452', 'creatorlist' => { '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '10143', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Nep', 'eprintid' => '10143', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'E.I.', 'creators_id' => undef } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '4', 'editors_name_honourific' => undef, 'admin_note' => undef, 'event_title' => undef, 'date_type' => 'published', 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2011', 'fileinfo' => '/style/images/fileicons/application_pdf.png;/10143/1/ConwayPoly.pdf', 'status_changed_second' => '54', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'Polysaccharide gum matrix tablets for oral controlled delivery of Cimetidine', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/01/01/43', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'public', 'lastmod_minute' => '29', 'refereed' => 'TRUE', 'contact_email' => undef, 'copyright_holders' => undef, 'date_day' => undef, 'gscholar_impact' => undef, 'official_url' => 'http://www.jpsr.pharmainfo.in/Documents/Volumes/Vol2Issue11/jpsr%2002101105.pdf', 'succeeds' => undef, 'datestamp_month' => '4', 'commentary' => undef, 'lastmod_day' => '14', 'publisher' => 'Pharmainfo Publications', 'pagerange' => '708-716', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2011', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'Journal of Pharmaceutical Sciences and Research', 'lastmod_second' => '54', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '0975-1459', 'datestamp_hour' => '15', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '54', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 11, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '10143', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2011', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '4', 'event_dates' => undef, 'fulltimestamp' => '20101100', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '15', 'number' => '11', 'rev_number' => '8', 'edit_lock_user' => '6', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '0', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'Q1', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '29', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '14', 'datestamp_day' => '14', 'abstract' => 'Matrix-based tablets using 40 %w/w grewia gum were prepared by direct compression to contain cimetidine as novel drug. The formulations were compared with similar formulations using hydroxypropyl methylcelluose (Methocel®), gum arabic, carboxy methylcellulose (Blanose®), or ethyl cellulose (Ethocel®) as polymer matrix. Also binary composite matrices containing grewia gum and the reference polymers (40 %w/w total polymer concentration in a ratio of 1:1) were directly compressed. In addition to tablet properties, swelling, erosion, kinetics of drug release from the matrices and stability of the tablet formulations were also investigated. In vitro drug release studies reveal that grewia gum can control the release of cimetidine from tablets for up to 12 hours. This strong sustained-release potential of grewia polysaccharide gum was superior to hydrophilic matrices of hydroxypropyl methylcellulose, carboxy methylcellulose and gum arabic. The release of drug from the grewia polysaccharide gum matrices follows Higuchi kinetic models. There was synergy between grewia gum and HPMC in delaying the release of cimetidine from tablets. Grewia gum may therefore prove a useful excipient when used alone, or in combination with other polymers to modify the release of soluble drugs from polymeric matrices', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '6', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '29', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => undef, 'volume' => '2', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2010', 'status_changed_hour' => '15', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '8941' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1288871213', 'creatorlist' => { '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Nimmannit', 'eprintid' => '8941', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'Ubonthip', 'creators_id' => undef }, '4' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Wang', 'eprintid' => '8941', 'creators_name_honourific' => '', 'pos' => '4', 'creators_name_given' => 'Yongfeng', 'creators_id' => undef }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Suppasansatorn', 'eprintid' => '8941', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'Panassaya', 'creators_id' => undef }, '3' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Du', 'eprintid' => '8941', 'creators_name_honourific' => '', 'pos' => '3', 'creators_name_given' => 'Lingran', 'creators_id' => undef }, '2' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '8941', 'creators_name_honourific' => '', 'pos' => '2', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '11', 'editors_name_honourific' => undef, 'admin_note' => undef, 'event_title' => undef, 'date_type' => 'published', 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2010', 'fileinfo' => '', 'status_changed_second' => '33', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'Microemulsions as topical delivery vehicles for the anti-melanoma prodrug, temozolomide hexyl ester (TMZA-HE)', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/00/89/41', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'none', 'lastmod_minute' => '50', 'refereed' => 'TRUE', 'contact_email' => undef, 'copyright_holders' => undef, 'date_day' => undef, 'gscholar_impact' => undef, 'official_url' => 'http://dx.doi.org/10.1211/jpp.59.6.0005', 'succeeds' => undef, 'datestamp_month' => '11', 'commentary' => undef, 'lastmod_day' => '4', 'publisher' => 'John Wiley ', 'pagerange' => '787-794', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2010', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'Journal of Pharmacy and Pharmacology', 'lastmod_second' => '33', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '0022-3573', 'datestamp_hour' => '11', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '33', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 6, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '8941', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2010', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '11', 'event_dates' => undef, 'fulltimestamp' => '20070600', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '11', 'number' => '6', 'rev_number' => '8', 'edit_lock_user' => '3483', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '0', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'Q1', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '50', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '4', 'datestamp_day' => '4', 'abstract' => 'A prodrug, temozolomide acid hexyl ester (TMZA-HE), was identified as a skin-deliverable congener for temozolomide (TMZ) to treat skin cancers. Poor solubility and instability of TMZA-HE rendered a serious challenge for formulation of a topical preparation. Microemulsions (ME) were chosen as a potential vehicle for TMZA-HE topical preparations. ME systems were constructed with either oleic acid (OA) or isopropyl myristate (IPM) as the oil phase and tocopheryl (vitamin E) polyethylene glycol 1000 succinate (VE-TPGS) as a surfactant. Topical formulations of OA and IPM ME systems demonstrated beneficial solubilising ability and provided a stable environment for the prodrug, TMZA-HE. Significant differences between the microstructures of OA and IPM ME systems were revealed by freeze fracture electron microscopy (FFEM) and different loading abilities and permeation potencies between the two systems were also identified. In permeation studies, IPM ME systems, with inclusion of isopropyl alcohol (IPA) as a co-surfactant, significantly increased TMZA-HE permeation through silicon membranes and rat skin resulting in less drug retention within the skin, while OA ME systems demonstrated higher solubilising ability and a higher concentration of TMZA-HE retained within the skin. Therefore IPM ME systems are promising for transdermal delivery of TMZA-HE and OA ME systems may be a suitable choice for a topical formulation of TMZA-HE.', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '3483', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '50', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => 'doi:10.1211/jpp.59.6.0005', 'volume' => '59', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2007', 'status_changed_hour' => '11', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '8958' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1288949820', 'creatorlist' => { '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '8958', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Griffin', 'eprintid' => '8958', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'K. 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Serum antibody responses and T cell proliferative responses were measured in groups of Balb/c mice which were injected intraperitoneally with single or double emulsion preparations of either V/IFN-? or V alone in a range of dose levels. Groups which received V antigen co-encapsulated with IFN-? produced higher V-specific antibody responses, predominantly of the IgG1 isotype. Administration of 25 ?g V/IFN-? in a single emulsion resulted in a significantly increased (p<0.05) splenic T cell proliferative response to V antigen compared with other formulations. It was concluded that IFN-? co-encapsulated with V antigen in poly(L)lactide microspheres acted as an adjuvant and increased antigen specific systemic immune responses. Therefore, co-encapsulation with IFN-? may result in effective single dose vaccines by increasing the immunogenicity of the formulations. 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'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'chscr', 'institution' => undef, 'subjects' => 'R1', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '5', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '1', 'datestamp_day' => '1', 'abstract' => 'Clinicians often find it difficult to devote sufficient time to develop proposals that will investigate issues that enhance the patient experience. Thus, clinicians need to access researchers and academics who can assist in developing research proposals, undertake service evaluation, audit current practice, provide advice on best practice and offer education that maintains clinical knowledge and skills. The University of Huddersfield recognised the challenges faced by clinicians in undertaking research in the specialist area of skin, and in 2011 formed the Skin Interface Sciences (SIS) Research Group. This article outlines its development and achievements to date.', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '116', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '5', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => undef, 'volume' => '27', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2013', 'status_changed_hour' => '12', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '8509' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1308048514', 'creatorlist' => { '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '8509', 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permeation chromatography (GPC), scanning electron microscopy (SEM), dilute solution viscometry, differential scanning calorimetry (DSC) and thermogrametric analysis of the extracted samples. Spectroscopic techniques such as x-ray photoelectron spectroscopy (XPS), fourier-transformed infrared (FT-IR), solid-state nuclear magnetic resonance (NMR), and 1H and 13C NMR techniques were also used to characterize the gum. The results showed that grewia gum is a typically amorphous polysaccharide gum containing glucose, rhamnose, galactose, arabinose and xylose as neutral sugars. It has an intrinsic viscosity of 48.36 ± 0.37 dl/g and an average molecular weight of 5925 kDa expressed as the pullulan equivalent. The gum slowly hydrated in water, dispersing and swelling to form a highly viscous dispersion exhibiting pseudoplastic flow behaviour. The polysaccharide gum is thermally stable and may have application as stabilizer or suspending agent in foods, cosmetics and in pharmaceuticals. It may have application as a binder or sustained-release polymer matrix in tablets or granulations. 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=> undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2014', 'fileinfo' => '/style/images/fileicons/application_pdf.png;/21548/1/Mahdi_et_al_ijpfor_repository.pdf', 'status_changed_second' => '28', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'Evaluation of gellan gum fluid gels as modified release oral liquids ', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/02/15/48', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'public', 'lastmod_minute' => '56', 'refereed' => 'TRUE', 'contact_email' => 'b.r.conway@hud.ac.uk', 'copyright_holders' => undef, 'date_day' => 20, 'gscholar_impact' => undef, 'official_url' => 'http://dx.doi.org/10.1016/j.ijpharm.2014.08.044', 'succeeds' => undef, 'datestamp_month' => '9', 'commentary' => undef, 'lastmod_day' => '16', 'publisher' => 'Elsevier', 'pagerange' => '335-343', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2014', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'International Journal of Pharmaceutics', 'lastmod_second' => '29', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '0378-5173', 'datestamp_hour' => '14', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '29', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 11, 'rights' => undef, 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A potential route to achieve modified release in oral liquids is by using fluid (sheared) gels formed by introducing a shear field during gelation in gel-forming biopolymers. These fluid gels can act as pourable viscoelastic fluids but retain true gel micro/nano structure. Here, we have demonstrated that fluid gels have potential as paediatric oral liquids preventing release of ibuprofen in simulated gastric fluid. Subsequent release at pH 7.4 was affected by the duration of exposure and magnitude of acid pH with a linear relationship between onset of release and the preceding acidic exposure duration. Delayed release was a result of increasing gel stiffness, a consequence of the acidity of the initial release media and exposure time. A much faster release rate was measured when exposure time in acid was 10 min compared with 60 min. This study highlights the potential to design fluid gels that are tuned to have a specified stiffness at a particular pH and exposure time. This could enable the preparation oral liquids with modified release behaviour.', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '8591', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '56', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => '10.1016/j.ijpharm.2014.08.044', 'volume' => '475', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2014', 'status_changed_hour' => '14', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '8961' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1288952382', 'creatorlist' => { '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Alpar', 'eprintid' => '8961', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'H.O.', 'creators_id' => undef }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '8961', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '11', 'editors_name_honourific' => undef, 'admin_note' => undef, 'event_title' => undef, 'date_type' => 'published', 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2010', 'fileinfo' => '', 'status_changed_second' => '6', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'Single and Coencapsulation of lnterferon-? in Biodegradable PLA Microspheres for Optimization of Multicomponent Vaccine Delivery Vehicles', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/00/89/61', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'none', 'lastmod_minute' => '23', 'refereed' => 'TRUE', 'contact_email' => undef, 'copyright_holders' => undef, 'date_day' => undef, 'gscholar_impact' => undef, 'official_url' => 'http://dx.doi.org/10.3109/10717549709051876', 'succeeds' => undef, 'datestamp_month' => '11', 'commentary' => undef, 'lastmod_day' => '5', 'publisher' => 'Informa Healthcare', 'pagerange' => '75-80', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2010', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'Drug Delivery', 'lastmod_second' => '6', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '1071-7544', 'datestamp_hour' => '10', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '6', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 4, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '8961', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2010', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '11', 'event_dates' => undef, 'fulltimestamp' => '19970400', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '10', 'number' => '2', 'rev_number' => '8', 'edit_lock_user' => '3483', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '0', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'Q1', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '23', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '5', 'datestamp_day' => '5', 'abstract' => 'Interferon-? (IFN-?) is a cytokine with potential for application in immunotherapy. Because of side effects following systemic administration, the use of such cytokines has been limited. The encapsulation of such agents in biodegradable microspheres is desirable, facilitating controlled release of drug from targetable devices. The combination of cytokines with antigens in a microsphere system may be of practicable value in providing a safe and novel class of carrier. Low-molecular-weight poly (L-lactide) (PLLA) was used for microsphere production by both single- and double-emulsion solvent evaporation techniques. The small microspheres produced in this study have the potential for mucosal delivery, desirable for vaccine delivery systems, being in the region of 1 ?m in diameter with smooth spherical surfaces. The effect of inclusion of diluent proteins on the encapsulation efficiency and release characteristics of both types of preparations is discussed together with the mechanisms of release. The coencapsulation of IFN-? with other proteins in such formulations requires investigation of the effect of each ingredient on the subsequent particle formation and release characteristics.', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '3483', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '23', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => 'doi:10.3109/10717549709051876', 'volume' => '4', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '1997', 'status_changed_hour' => '10', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '8507' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1284115181', 'creatorlist' => { '4' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '8507', 'creators_name_honourific' => '', 'pos' => '4', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' }, '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Hendry', 'eprintid' => '8507', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'E.R.', 'creators_id' => undef }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Karpanen', 'eprintid' => '8507', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'T.J.', 'creators_id' => undef }, '3' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Lambert', 'eprintid' => '8507', 'creators_name_honourific' => '', 'pos' => '3', 'creators_name_given' => 'P.A.', 'creators_id' => undef }, '2' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Worthington', 'eprintid' => '8507', 'creators_name_honourific' => '', 'pos' => '2', 'creators_name_given' => 'T.', 'creators_id' => undef } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '9', 'editors_name_honourific' => undef, 'admin_note' => undef, 'event_title' => undef, 'date_type' => 'published', 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2010', 'fileinfo' => '', 'status_changed_second' => '8', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'Chlorhexidine : skin permeation and antisepsis', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/00/85/07', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'none', 'lastmod_minute' => '7', 'refereed' => 'FALSE', 'contact_email' => undef, 'copyright_holders' => undef, 'date_day' => undef, 'gscholar_impact' => undef, 'official_url' => 'http://www.euromedcommunications.com/files/products/contents%20ip%20June%2010.pdf', 'succeeds' => undef, 'datestamp_month' => '9', 'commentary' => undef, 'lastmod_day' => '10', 'publisher' => 'Euromed Communications Ltd', 'pagerange' => '11-14', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2010', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'Industrial pharmacy', 'lastmod_second' => '8', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '1741-4911', 'datestamp_hour' => '11', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '8', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 6, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '8507', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2010', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '9', 'event_dates' => undef, 'fulltimestamp' => '20100600', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '11', 'number' => undef, 'rev_number' => '7', 'edit_lock_user' => '3483', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '1', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'RS', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '7', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '10', 'datestamp_day' => '10', 'abstract' => 'This study from Aston University shows that skin penetration and antimicrobial efficiency of chlorhexidine can be enhanced by combining it with eucalyptus oil.', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '3483', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '7', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => undef, 'volume' => '26', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2010', 'status_changed_hour' => '11', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '15821' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1414059063', 'creatorlist' => { '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '15821', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'Barbara R.', 'creators_id' => 'b.r.conway@hud.ac.uk' }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Hendry', 'eprintid' => '15821', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'E. R.', 'creators_id' => undef }, '2' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Worthington', 'eprintid' => '15821', 'creators_name_honourific' => '', 'pos' => '2', 'creators_name_given' => 'T.', 'creators_id' => undef } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '11', 'editors_name_honourific' => undef, 'admin_note' => undef, 'event_title' => undef, 'date_type' => 'published', 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2012', 'fileinfo' => '/style/images/fileicons/application_pdf.png;/15821/1/ijms%2D13%2D14016.pdf', 'status_changed_second' => '12', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'Digluconate and Isopropyl Alcohol Biocide Formulation', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/01/58/21', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'public', 'lastmod_minute' => '18', 'refereed' => 'TRUE', 'contact_email' => undef, 'copyright_holders' => undef, 'date_day' => 30, 'gscholar_impact' => undef, 'official_url' => 'http://www.mdpi.com/journal/ijms', 'succeeds' => undef, 'datestamp_month' => '11', 'commentary' => undef, 'lastmod_day' => '12', 'publisher' => 'MDIP', 'pagerange' => '14016-14025', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2012', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'International Journal of Molecular Sciences', 'lastmod_second' => '12', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '1422-0067', 'datestamp_hour' => '12', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '12', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 10, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '15821', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2012', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '11', 'event_dates' => undef, 'fulltimestamp' => '20121030', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '12', 'number' => '11', 'rev_number' => '9', 'edit_lock_user' => '6', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '0', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R.', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'RM', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '18', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '12', 'datestamp_day' => '12', 'abstract' => 'Effective surface disinfection is a fundamental infection control strategy within healthcare. This study assessed the antimicrobial efficacy of novel biocide formulations comprising 5% and 2% eucalyptus oil (EO) combined with 2% chlorhexidine digluconate (CHG) and 70% isopropyl alcohol (IPA) contained within a wipe. The efficacy of this novel antimicrobial formulation to remove and eliminate methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli and Candida albicans from steel surfaces was investigated. Adpression studies of pre-contaminated wipes were also utilised to assess their potential to induce cross-contamination between hard surfaces. Furthermore, the bactericidal nature of the EO-formulation was established in addition to time-kill. The EO-containing formulations demonstrated bactericidal antimicrobial efficacy against all microorganisms and did not induce surface cross-contamination. There was no significant difference (p < 0.05) between the 5% and 2% EO formulations in their ability to remove microorganisms from steel surfaces, however both significantly (p < 0.05) removed more than the control formulations. Microbial biofilms were eliminated within 10 min (p < 0.05) when exposed to the EO formulations. Our novel EO-formulation demonstrated rapid antimicrobial efficacy for potential disinfection and elimination of microbial biofilms from hard surfaces and may therefore be a useful adjunct to current infection control strategies currently employed within healthcare facilities.', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '6307', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '18', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => '10.3390/ijms131114016', 'volume' => '13', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2012', 'status_changed_hour' => '12', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '8956' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1288948516', 'creatorlist' => { '6' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Grattan', 'eprintid' => '8956', 'creators_name_honourific' => '', 'pos' => '6', 'creators_name_given' => 'Tim J.', 'creators_id' => undef }, '4' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Irwin', 'eprintid' => '8956', 'creators_name_honourific' => '', 'pos' => '4', 'creators_name_given' => 'William J.', 'creators_id' => undef }, '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Shiran', 'eprintid' => '8956', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'M.R.', 'creators_id' => undef }, '3' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '8956', 'creators_name_honourific' => '', 'pos' => '3', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Rostami-Hodjegan', 'eprintid' => '8956', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'A.', 'creators_id' => undef }, '2' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Tucker', 'eprintid' => '8956', 'creators_name_honourific' => '', 'pos' => '2', 'creators_name_given' => 'G.T.', 'creators_id' => undef }, '5' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Shaw', 'eprintid' => '8956', 'creators_name_honourific' => '', 'pos' => '5', 'creators_name_given' => 'Lance R.', 'creators_id' => undef } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '11', 'editors_name_honourific' => undef, 'admin_note' => undef, 'event_title' => undef, 'date_type' => 'published', 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2010', 'fileinfo' => '', 'status_changed_second' => '38', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'A New Rapidly Absorbed Paracetamol Tablet Containing Sodium Bicarbonate. II. Dissolution Studies and In Vitro/In Vivo Correlation', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/00/89/56', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'none', 'lastmod_minute' => '22', 'refereed' => 'TRUE', 'contact_email' => undef, 'copyright_holders' => undef, 'date_day' => undef, 'gscholar_impact' => undef, 'official_url' => 'http://dx.doi.org/10.1081/DDC-120003449', 'succeeds' => undef, 'datestamp_month' => '11', 'commentary' => undef, 'lastmod_day' => '5', 'publisher' => 'Informa Healthcare', 'pagerange' => '533-543', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2010', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'Drug Development and Industrial Pharmacy', 'lastmod_second' => '38', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '0363-9045', 'datestamp_hour' => '9', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '38', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 5, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '8956', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2010', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '11', 'event_dates' => undef, 'fulltimestamp' => '20020500', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '9', 'number' => '5', 'rev_number' => '8', 'edit_lock_user' => '3483', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '1', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'QD', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '22', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '5', 'datestamp_day' => '5', 'abstract' => 'The objective of this study was to compare the in vitro dissolution profile of a new rapidly absorbed paracetamol tablet containing sodium bicarbonate (PS) with that of a conventional paracetamol tablet (P), and to relate these by deconvolution and mapping to in vivo release. The dissolution methods used include the standard procedure described in the USP monograph for paracetamol tablets, employing buffer at pH 5.8 or 0.05 M HCl at stirrer speeds between 10 and 50 rpm. The mapping process was developed and implemented in Microsoft Excel® worksheets that iteratively calculated the optimal values of scale and shape factors which linked in vivo time to in vitro time. The in vitro–in vivo correlation (IVIVC) was carried out simultaneously for both formulations to produce common mapping factors. The USP method, using buffer at pH 5.8, demonstrated no difference between the two products. However, using an acidic medium the rate of dissolution of P but not of PS decreased with decreasing stirrer speed. A significant correlation (r = 0.773; p<.00001) was established between in vivo release and in vitro dissolution using the profiles obtained with 0.05 M HCl and a stirrer speed of 30 rpm. The scale factor for optimal simultaneous IVIVC in the fasting state was 2.54 and the shape factor was 0.16; corresponding values for mapping in the fed state were 3.37 and 0.13 (implying a larger in vitro–in vivo time difference but reduced shape difference in the fed state). The current IVIVC explains, in part, the observed in vivo variability of the two products. The approach to mapping may also be extended to different batches of these products, to predict the impact of any changes of in vitro dissolution on in vivo release and plasma drug concentration–time profiles.', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '3483', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '22', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => 'doi:10.1081/DDC-120003449', 'volume' => '28', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2002', 'status_changed_hour' => '9', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '8957' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1288949083', 'creatorlist' => { '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Timmins', 'eprintid' => '8957', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'Peter', 'creators_id' => undef }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Tran', 'eprintid' => '8957', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'Christine D.H.', 'creators_id' => undef }, '3' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Irwin', 'eprintid' => '8957', 'creators_name_honourific' => '', 'pos' => '3', 'creators_name_given' => 'William J.', 'creators_id' => undef }, '2' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '8957', 'creators_name_honourific' => '', 'pos' => '2', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '11', 'editors_name_honourific' => undef, 'admin_note' => undef, 'event_title' => undef, 'date_type' => 'published', 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2010', 'fileinfo' => '', 'status_changed_second' => '32', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'Investigation of the coordinated functional activities of cytochrome P450 3A4 and P-glycoprotein in limiting the absorption of xenobiotics in Caco-2 cells', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/00/89/57', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'none', 'lastmod_minute' => '28', 'refereed' => 'TRUE', 'contact_email' => undef, 'copyright_holders' => undef, 'date_day' => undef, 'gscholar_impact' => undef, 'official_url' => 'http://dx.doi.org/10.1002/jps.1173', 'succeeds' => undef, 'datestamp_month' => '11', 'commentary' => undef, 'lastmod_day' => '5', 'publisher' => 'Wiley', 'pagerange' => '117-128', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2010', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'Journal of Pharmaceutical Sciences', 'lastmod_second' => '32', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '0022-3549', 'datestamp_hour' => '9', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '32', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 1, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '8957', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2010', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '11', 'event_dates' => undef, 'fulltimestamp' => '20020100', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '9', 'number' => '1', 'rev_number' => '8', 'edit_lock_user' => '3483', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '1', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'QD', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '28', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '5', 'datestamp_day' => '5', 'abstract' => 'The coordination of the functional activities of intestinal CYP3A4 and P-gp in limiting the absorption of xenobiotics in Caco-2 cells was investigated. Growing Caco-2 cells were exposed to increasing concentrations of doxorubicin (1–2 ?M) in plastic flasks to encourage a subpopulation of cells, that displayed an intrinsically higher multidrug resistance (mdr) phenotype than the parent cells, to survive and grow. Doxorubicin-exposed (hereinafter referred to as type I cells) and nonexposed Caco-2 cells (parent cells) on collagen-coated inserts were also treated with either 0 (control) or 0.25 ?M 1?,25-dihydroxyvitamin D3 to promote cellular CYP3A4 expression. Increased P-gp protein expression, as detected by Western blotting, was noted in type I cells (213?±?54.35%) compared to that of parent cells (100?±?6.05%). Furthermore, they retained significantly less [3H]vincristine sulphate (p?<?0.05), a P-gp substrate, after efflux (272.89?±?11.86 fmol/mg protein) than the parent cells (381.39 ± 61.82 fmol/mg protein). The expression of CYP3A4 in parental cells after 1?,25-dihydroxyvitamin D3 treatment was quantified to be 76.2?±?7.6 pmol/mg protein and comparable with that found in human jejunal enterocytes (70.0?±?20.0 pmol/mg protein). Type I cells, however, expressed a very low quantity of CYP3A4 both before and after the treatment that was beyond the minimum detection limit of Western blotting. Functionally, the rates of 1-hydroxylation of midazolam by CYP3A for both cell types ranged from 257.0?±?20.0 to 1057.0?±?46.0 pmol/min/mg protein. Type I cells, although having a higher P-gp expression and activity comparatively, metabolized midazolam less extensively than the parent cells. The results suggested that there were noncoordinated functional activities of intestinal CYP3A4 and P-gp in Caco-2 cells, although they both functioned independently to minimize intestinal epithelial absorption of xenobiotics. © 2002 Wiley-Liss, Inc. and the American Pharmaceutical Association J Pharm Sci 91:117–128, 2002 ', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '3483', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '28', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => 'doi:10.1002/jps.1173', 'volume' => '91', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2002', 'status_changed_hour' => '9', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '8944' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1288873742', 'creatorlist' => { '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Irwin', 'eprintid' => '8944', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'William J.', 'creators_id' => undef }, '3' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '8944', 'creators_name_honourific' => '', 'pos' => '3', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Shaw', 'eprintid' => '8944', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'Lance R.', 'creators_id' => undef }, '2' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Grattan', 'eprintid' => '8944', 'creators_name_honourific' => '', 'pos' => '2', 'creators_name_given' => 'Tim J.', 'creators_id' => undef } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '11', 'editors_name_honourific' => undef, 'admin_note' => undef, 'event_title' => undef, 'date_type' => 'published', 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2010', 'fileinfo' => '', 'status_changed_second' => '12', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'The Effect of Selected Water-Soluble Excipients on the Dissolution of Paracetamol and Ibuprofen', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/00/89/44', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'none', 'lastmod_minute' => '33', 'refereed' => 'TRUE', 'contact_email' => undef, 'copyright_holders' => undef, 'date_day' => undef, 'gscholar_impact' => undef, 'official_url' => 'http://dx.doi.org/10.1080/03639040500215784', 'succeeds' => undef, 'datestamp_month' => '11', 'commentary' => undef, 'lastmod_day' => '4', 'publisher' => 'Informa Healthcare', 'pagerange' => '515-525', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2010', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'Drug Development and Industrial Pharmacy', 'lastmod_second' => '12', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '0363-9045', 'datestamp_hour' => '12', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '12', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 6, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '8944', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2010', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '11', 'event_dates' => undef, 'fulltimestamp' => '20050600', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '12', 'number' => '6', 'rev_number' => '8', 'edit_lock_user' => '3483', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '0', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'Q1', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '33', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '4', 'datestamp_day' => '4', 'abstract' => 'The purpose of this investigation was to study the dissolution behavior of paracetamol and ibuprofen in the presence of a range of selected potential excipients. First, a pH-solubility profile was generated for both drugs, and the effect of changing hydrodynamic conditions on the intrinsic dissolution rate was investigated. It was established that both drugs dissolved according to the diffusion-layer model. Paracetamol solubility (approximately 20.3 mg mL? 1) did not vary from pH 1.2–8.0, corresponding to the in vivo range in the gastrointestinal tract. Ibuprofen had an intrinsic solubility of approximately 0.06 mg mL? 1, and pKa was calculated as 4.4. Second, the effects of selected potential excipients (lactose, potassium bicarbonate, sodium bicarbonate, sodium chloride, and tartaric acid) were evaluated by measuring the effect of the inclusion of each additive in the dissolution medium on drug solubility, drug intrinsic dissolution rate, and solution viscosity. The results were evaluated using the diffusion-layer model, and it was determined that for paracetamol, the collected data fitted the model for all the excipients studied. For ibuprofen, it was found that there were differences between the excipients that raised the solution pH above the pKa to those that did not. For the excipients raising the pH above the pKa, the effect on intrinsic dissolution rate was not as high as that expected from the change in drug solubility. It was postulated that this might be due to lack of penetration of the excipient into the drug boundary layer microenvironment. Formulators may calculate the effect of adding an excipient based on solubility increases but may not find the dissolution rate improvement expected.', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '3483', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '33', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => 'doi:10.1080/03639040500215784', 'volume' => '31', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2005', 'status_changed_hour' => '12', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '8947' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1288877513', 'creatorlist' => { '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Irwin', 'eprintid' => '8947', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'William J.', 'creators_id' => undef }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Shaw', 'eprintid' => '8947', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'Lance R.', 'creators_id' => undef }, '3' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '8947', 'creators_name_honourific' => '', 'pos' => '3', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' }, '2' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Grattan', 'eprintid' => '8947', 'creators_name_honourific' => '', 'pos' => '2', 'creators_name_given' => 'Tim J.', 'creators_id' => undef } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '11', 'editors_name_honourific' => undef, 'admin_note' => undef, 'event_title' => undef, 'date_type' => 'published', 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2010', 'fileinfo' => '', 'status_changed_second' => '22', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'The influence of excipients on the diffusion of ibuprofen and paracetamol in gastric mucus', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/00/89/47', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'none', 'lastmod_minute' => '41', 'refereed' => 'TRUE', 'contact_email' => undef, 'copyright_holders' => undef, 'date_day' => undef, 'gscholar_impact' => undef, 'official_url' => 'http://dx.doi.org/10.1016/j.ijpharm.2004.11.028', 'succeeds' => undef, 'datestamp_month' => '11', 'commentary' => undef, 'lastmod_day' => '4', 'publisher' => 'Elsevier', 'pagerange' => '145-154', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2010', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'International Journal of Pharmaceutics', 'lastmod_second' => '22', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '0378-5173', 'datestamp_hour' => '13', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '22', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 1, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '8947', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2010', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '11', 'event_dates' => undef, 'fulltimestamp' => '20050100', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '13', 'number' => '1-2', 'rev_number' => '8', 'edit_lock_user' => '3483', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '0', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'Q1', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '41', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '4', 'datestamp_day' => '4', 'abstract' => 'The aim of this study was to examine the diffusion of commonly administered analgesics, ibuprofen and paracetamol, through gastric mucus. As ibuprofen and paracetamol are often formulated with alkalising excipients, or are commonly co-administered with antacids that have been demonstrated to alter their absorption, diffusion was also studied in the presence of a range of soluble and insoluble antacids or buffering agents. The effect of pH, which has been demonstrated to modify the properties of mucus, was also studied. Mucus was a significant barrier to diffusion for both drugs, compared to an unstirred aqueous layer with diffusion rates significantly lower in the presence of a mucus barrier for both drugs; ibuprofen diffusion also demonstrated a significant increase in the lag time. Paracetamol diffusion was not significantly affected by addition of any antacid, whereas ibuprofen rates were affected and the diffusion lag time for ibuprofen was significantly reduced in all cases. Isolated increases in pH increased the rate and reduced the lag time for ibuprofen diffusion. It was shown that mucus acts as a passive barrier in the case of paracetamol diffusion, and an interactive barrier to ibuprofen diffusion. Changes in mucus viscosity at different pH values may be responsible for the observed changes in ibuprofen diffusion rate.', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '3483', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '41', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => 'doi:10.1016/j.ijpharm.2004.11.028', 'volume' => '290', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2005', 'status_changed_hour' => '13', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '20475' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1401784694', 'creatorlist' => { '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '20475', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Adebisi', 'eprintid' => '20475', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'Adeola O.', 'creators_id' => undef } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '6', 'editors_name_honourific' => undef, 'admin_note' => undef, 'event_title' => undef, 'date_type' => 'published', 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2014', 'fileinfo' => '/style/images/fileicons/application_pdf.png;/20475/1/ConwayIJP_lectin_14.pdf', 'status_changed_second' => '55', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'Lectin-conjugated microspheres for eradication of Helicobacter pylori infection and interaction with mucus', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/02/04/75', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'public', 'lastmod_minute' => '38', 'refereed' => 'TRUE', 'contact_email' => 'b.r.conway@hud.ac.uk', 'copyright_holders' => undef, 'date_day' => undef, 'gscholar_impact' => undef, 'official_url' => 'http://dx.doi.org/10.1016/j.ijpharm.2014.04.070', 'succeeds' => undef, 'datestamp_month' => '6', 'commentary' => undef, 'lastmod_day' => '3', 'publisher' => 'Elsevier', 'pagerange' => '28-40', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2014', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'International Journal of Pharmaceutics', 'lastmod_second' => '55', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '0378-5173', 'datestamp_hour' => '8', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '55', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 8, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '20475', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2014', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '6', 'event_dates' => undef, 'fulltimestamp' => '20140800', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '8', 'number' => '1-2', 'rev_number' => '9', 'edit_lock_user' => '6', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '0', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'R1', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '35', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '3', 'datestamp_day' => '3', 'abstract' => 'Using second generation mucoadhesives may enhance targeting antibiotics for eradication of Helicobacter pylori from the stomach for the treatment of peptic ulcer. The aim of this research was to prepare and characterise ethylcellulose/chitosan microspheres containing clarithromycin with their surfaces functionalised with concanavalin A to produce a floating-mucoadhesive formulation. The microspheres were prepared using an emulsification-solvent evaporation method. Particle size, surface morphology, in vitro buoyancy profile, zeta potential, drug entrapment efficiency, in vitro drug release and release kinetics of the particles were determined. Lectin was conjugated to the microsphere surface using two-stage carbodiimide activation and confirmed using FTIR, fluorescence studies and zeta potential measurements. Conjugation ranged from 11 to 15 ?g Con A/mg microspheres which represents over 56% efficiency although there was some drug loss during the conjugation process. Conjugation did not have a significant effect on the buoyancy and release of drug from the microspheres using a mucus diffusion model with 53% and 40% of drug released from unconjugated and conjugated microspheres within 12 h. Conjugation improved mucoadhesion and interaction with porcine gastric mucin compared to unconjugated microspheres. The buoyancy and improved mucoadhesion of the microspheres provides potential for delivery of clarithromycin and other drugs to the stomach.', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '6', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '35', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => 'doi:10.1016/j.ijpharm.2014.04.070', 'volume' => '470', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2014', 'status_changed_hour' => '8', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '8954' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1288947580', 'creatorlist' => { '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '8954', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Lambert', 'eprintid' => '8954', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'P.A.', 'creators_id' => undef } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '11', 'editors_name_honourific' => undef, 'admin_note' => undef, 'event_title' => undef, 'date_type' => 'published', 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2010', 'fileinfo' => '', 'status_changed_second' => '21', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'Pharmaceutical quality of ceftriaxone generic drug products compared with rocephin', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/00/89/54', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'none', 'lastmod_minute' => '4', 'refereed' => 'TRUE', 'contact_email' => undef, 'copyright_holders' => undef, 'date_day' => undef, 'gscholar_impact' => undef, 'official_url' => 'http://www.jchemother.it/cgi-bin/digisuite.exe/product?ID=123&IDCategory=15', 'succeeds' => undef, 'datestamp_month' => '11', 'commentary' => undef, 'lastmod_day' => '5', 'publisher' => 'ESIFT srl', 'pagerange' => '402-413', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2010', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'Journal of Chemotherapy', 'lastmod_second' => '21', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '1120-009X', 'datestamp_hour' => '9', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '21', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 8, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '8954', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2010', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '11', 'event_dates' => undef, 'fulltimestamp' => '20030800', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '9', 'number' => '4', 'rev_number' => '6', 'edit_lock_user' => '3483', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '1', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'QD', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '4', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '5', 'datestamp_day' => '5', 'abstract' => ' The pharmaceutical qualities of 34 ceftriaxone generic products were compared with Rocephin® as the reference standard. Quality standards specified in the European and US Pharmacopoeias were violated on 18 occasions, including those for sterility (4 products) and impurities (5 products). All 34 generics tested failed to meet Roche specifications for Rocephin®, with 100 contraventions of the Roche Pharmaceutical standards. The most common failures amongst generic drug products were clarity of solution (30 products) and presence of thiotriazinone (33 products). ', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '3483', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '4', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => undef, 'volume' => '15', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2003', 'status_changed_hour' => '9', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '8942' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1288871781', 'creatorlist' => { '4' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Timmins', 'eprintid' => '8942', 'creators_name_honourific' => '', 'pos' => '4', 'creators_name_given' => 'Peter', 'creators_id' => undef }, '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'David', 'eprintid' => '8942', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'Sarah E.', 'creators_id' => undef }, '3' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '8942', 'creators_name_honourific' => '', 'pos' => '3', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Cheung', 'eprintid' => '8942', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'Eugene Y.', 'creators_id' => undef }, '2' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Harris', 'eprintid' => '8942', 'creators_name_honourific' => '', 'pos' => '2', 'creators_name_given' => 'Kenneth D.M.', 'creators_id' => undef } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '11', 'editors_name_honourific' => undef, 'admin_note' => undef, 'event_title' => undef, 'date_type' => 'published', 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2010', 'fileinfo' => '', 'status_changed_second' => '13', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'Structural properties of a family of hydrogen-bonded co-crystals formed between gemfibrozil and hydroxy derivatives of t-butylamine, determined directly from powder X-ray diffraction data', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/00/89/42', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'none', 'lastmod_minute' => '0', 'refereed' => 'TRUE', 'contact_email' => undef, 'copyright_holders' => undef, 'date_day' => undef, 'gscholar_impact' => undef, 'official_url' => 'http://dx.doi.org/10.1016/j.jssc.2006.12.036', 'succeeds' => undef, 'datestamp_month' => '11', 'commentary' => undef, 'lastmod_day' => '4', 'publisher' => 'Academic Press', 'pagerange' => '1068-1075', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2010', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'Journal of Solid State Chemistry', 'lastmod_second' => '13', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '0022-4596', 'datestamp_hour' => '12', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '13', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 3, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '8942', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2010', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '11', 'event_dates' => undef, 'fulltimestamp' => '20070300', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '12', 'number' => '3', 'rev_number' => '8', 'edit_lock_user' => '3483', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '0', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'Q1', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '0', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '4', 'datestamp_day' => '4', 'abstract' => 'We report the formation and structural properties of co-crystals containing gemfibrozil and hydroxy derivatives of t-butylamine H2NC(CH3)3?n(CH2OH)n, with n=0, 1, 2 and 3. In each case, a 1:1 co-crystal is formed, with transfer of a proton from the carboxylic acid group of gemfibrozil to the amino group of the t-butylamine derivative. All of the co-crystal materials prepared are polycrystalline powders, and do not contain single crystals of suitable size and/or quality for single crystal X-ray diffraction studies. Structure determination of these materials has been carried out directly from powder X-ray diffraction data, using the direct-space Genetic Algorithm technique for structure solution followed by Rietveld refinement. The structural chemistry of this series of co-crystal materials reveals well-defined structural trends within the first three members of the family (n=0, 1, 2), but significantly contrasting structural properties for the member with n=3. ', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '3483', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '0', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => 'doi:10.1016/j.jssc.2006.12.036', 'volume' => '180', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2007', 'status_changed_hour' => '12', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '18994' => { 'funders' => 'University of Huddersfield', 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => 'Pharmaceutical Electrostatics Tribo-electrification Flurbiprofen ', 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1384875751', 'creatorlist' => { '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Ghori', 'eprintid' => '18994', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'Mohammed U.', 'creators_id' => undef }, '4' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Panchmatia', 'eprintid' => '18994', 'creators_name_honourific' => '', 'pos' => '4', 'creators_name_given' => 'Pooja M.', 'creators_id' => 'p.panchmatia@hud.ac.uk' }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Šupuk', 'eprintid' => '18994', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'Enes', 'creators_id' => 'e.supuk@hud.ac.uk' }, '3' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Laity', 'eprintid' => '18994', 'creators_name_honourific' => '', 'pos' => '3', 'creators_name_given' => 'Peter R.', 'creators_id' => 'p.laity@hud.ac.uk' }, '2' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Asare-Addo', 'eprintid' => '18994', 'creators_name_honourific' => '', 'pos' => '2', 'creators_name_given' => 'Kofi', 'creators_id' => 'k.asare-addo@hud.ac.uk' }, '5' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '18994', 'creators_name_honourific' => '', 'pos' => '5', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '10', 'editors_name_honourific' => undef, 'admin_note' => undef, 'event_title' => undef, 'date_type' => 'published', 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2013', 'fileinfo' => '/style/images/fileicons/application_pdf.png;/18994/1/SupukInfluence%2Detal%2DManuscript_29092013.pdf|/style/images/fileicons/application_pdf.png;/18994/4/Supuk%2Detal_Figures_23072013.pdf|/style/images/fileicons/application_pdf.png;/18994/5/Supuk%2Detal_Tables_23072013.pdf', 'status_changed_second' => '0', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'The influence of salt formation on electrostatic and compression properties of flurbiprofen salts', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/01/89/94', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'public', 'lastmod_minute' => '38', 'refereed' => 'TRUE', 'contact_email' => 'e.supuk@hud.ac.uk', 'copyright_holders' => undef, 'date_day' => 15, 'gscholar_impact' => undef, 'official_url' => 'http://dx.doi.org/10.1016/j.ijpharm.2013.10.004', 'succeeds' => undef, 'datestamp_month' => '10', 'commentary' => undef, 'lastmod_day' => '1', 'publisher' => 'Elsevier', 'pagerange' => '118-127', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2013', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'International Journal of Pharmaceutics', 'lastmod_second' => '17', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '0378-5173', 'datestamp_hour' => '11', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '0', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 12, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '18994', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2014', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '1', 'event_dates' => undef, 'fulltimestamp' => '20131215', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '1', 'number' => '1', 'rev_number' => '21', 'edit_lock_user' => '6', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '0', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'Q1', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '11', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '29', 'datestamp_day' => '29', 'abstract' => 'Salt formation is an effective method of improving physicochemical properties of acidic and basic drugs. The selection of a salt form most suitable for drug development requires a well-designed screening strategy to ensure various issues are addressed in the early development stages. Triboelectrification of pharmaceutical powders may cause problems during processing such as segregation of components due to the effects of particle adhesion. However, very little work has been done on the effect of salt formation on triboelectrification properties. In this paper, salts of flurbiprofen were prepared by combining the drug with a selection of closely related amine counter ions. The aim of the work was to investigate the impact of the counter ion on electrostatic charge of the resultant salts to inform the salt selection process. The experimental results show the magnitude of charge and polarity of the flurbiprofen salts to be highly dependent on the type of counter ion selected for the salt formation. Furthermore, particle adhesion to the stainless steel surface of the shaking container and the salts’ compression properties were measured. The formed salts had lower electrostatic charges, improved tabletability, and resulted in reduced adhesion of these powders compared with the parent drug.', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '11131', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '11', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => '10.1016/j.ijpharm.2013.10.004', 'volume' => '458', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => 'Asare-Addo K., Kaialy W., Levina M., Rajabi-Siahboomi A.R., Ghori M. U., Supuk E., Laity P.R., Conway B.R and Nokhodchi A. 2013 The Influence of Agitation Sequence and Ionic Strength on in-vitro Drug Release from Hypromellose (E4M and K4M) ER Matrices - The use of the USP III Apparatus. Colloids Surf., B., 104: 54-60. Bastin, R.J., Bowker, M. J., Slater, B.J., 2000. Salt selection and optimisation for pharmaceutical new chemical entities.Org. Proc. Res. Dev., 4, 427-435. Chow, S.F., Chen, M., Shi, L., Chow, A.H. Sun, C.C., 2012. Simultaneously improving the mechanical properties, dissolution performance, and hygroscopicity of ibuprofen and flurbiprofen by cocrystallization with nicotinamide. Pharm. Res., 29, 1854-1865. Cushny, A.R. 2012. A Text-Book of Pharmacology and Therapeutics; Or, the Action of Drugs in Health and Disease, New York, Lea Brothers & Co. David, S.E., Timmins, P., Conway, B.R., 2012. Impact of the counter ion on the solubility and physicochemical properties of salts of carboxylic acid drugs, Drug Dev. Ind. Pharm., 38:1, 93-103. Elder, D. P., R. Holm, Diego, H.L., 2013. Use of pharmaceutical salts and cocrystals to address the issue of poor solubility. Int. J. Pharm., 453, 88-100. Fell, J.T., Newton, J.M., 1970. Determination of tablet strength by the diametral-compression test. J. Pharm. Sci., 59, 688-691. Fleming, S., Rohl, A. 2005. GDIS: a visualization program for molecular and periodic systems, Kristallgeometrie, 220 (5-6), 580-584. Gould, P.L., 1986. Salt selection for basic drugs. Int. J. Pharm., 33, 201-217. Greason, W., 2000, Investigation of a Test Methodology for Triboelectrification, J. Electrostat., 49, 245-256. Heckel, , R.W., 1961. An analysis of powder compaction phenonmenon T.Metllac Soc. AIME, 221, 1001-1008. Heckel, R.W., 1961a. Desity pressure relationship in powder compaction. T.Mettall Soc. AIME 221, 671-675. Kawakita, K., Ludde, K.H., 1970-1971. Some consideration on powder compression equations. Powder Tech.,4, 61-68. Khankari, R., Grant, D., 1995. Pharmaceutical Hydrates. ThermochimActa., 248, 61-79. Kumar, L., Amin, A., Bansal, A.K., 2008.Salt selection in drug development. Pharm.Technol., 3(32), 128-146. Lacoulonche, F., Chauvet, A., Masse, J., 1997, An investigation of flurbiprofen polymorphism by thermoanalytical and spectroscopic methods and a study of its interactions with poly-(ethylene glycol) 6000 by differential scanning calorimetry and modelling, Int. J. Pharm., 153 (2), 167-179. Matsusaka, S., Maruyama, H., Matsuyama, T., Ghadiri, M., 2010.Triboelectric charging of powders: A review. Chem. Eng. Sci., 65(22), 5781-5807. Matsusaka, S., Masuda, H., 2003, Electrostatics of Particles, Adv. Powder Technol., 14, 143-166. Morimoto, Y., Hatanaka, T., 1992. Prediction of skin permeability of drugs: comparison of human and hairless rat skin. J. Pharm. Pharmacol, 44, 634-639. Ramirez, M., 2010, Mechanical Properties of Flurbiprofen Salts, PhD. Thesis, University of Aston, Birmingham, UK. Schwalbe, C.H., Ramirez, M., Conway, B.R., Bache, C.J., Coles, S.J., Timmins, P., 2010. Structure and properties of (hydroxy)alkylammonium salts of flurbiprofen, Trans. Am. Cryst. Assoc., TR.01.8. Serajuddin, A.T.M., 2007. Salt formation to improve drug solubility. Adv. Drug Del., Rev., 59, 603-616. Socrates, G., 1994. Infrared characteristic group frequencies. New York, John Wiley & Sons, USA. Stahl, P.H., Wermuth, C.G., 2002. Handbook of Pharmaceutical Salts: Properties, Selection and Use, Zurich: Verlag Helvetica ChimicaActa. Šupuk E, Hassanpour A, Ahmadian H, Ghadiri M, Matsuyama T., 2011. Tribo-electrification and associated segregation of pharmaceutical bulk powders. KONA Powder Part J. 29, 208–223. Šupuk, E., Seiler, C., Ghadiri, M., 2009. Analysis of a simple test device for tribo-electric charging of bulk powders, Part. Part. Syst. Charact., 26, 7–16. Šupuk, E., Zarrebini, A., Reddy, J.P., Hughes, H., Leane, M.M., Tobyn, M.J., Timmins, P., Ghadiri, M., 2012. Tribo-electrification of active pharmaceutical ingredients and excipients. Powder Technol., 217, 427–434. Vrani?, E.,2003. Recent advances in the identification and prediction of polymorphs. Bosn. J. Basic. Med. Sci., 3, 32-36. Wang, J.J., Guillot, M.A., Bateman, S.D. Morris, K.R., 2004. Modeling of Adhesion in Tablet Compression. II. Compaction Studies Using a Compaction Simulator and an Instrumented Tablet Press. J. Pharm. Sci., 93, 407-417. Waterman, K.C., Adami, R.C., Alsante, K.M., Antipas, A.S., Arenson, D.R., Carrier, R., Hong, J., Landis, M.S., Lombardo, F., Shah, J.C., Shalaev, E., Smith, S.W., Wang, H., 2002. Hydrolysis in pharmaceutical formulations, Pharm. Dev. Technol., 7, 113-146. Wouters, J, Quéré, L., 2012. Pharmaceutical Salts and Co-crystals. Cambridge: Royal Society of Chemistry. 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The mechanisms controlling release of drug from solid dispersions are not fully understood and proposed theories are dependent on an understanding of the dissolution behaviour of both components of the dispersion. This study uses microviscometry to measure small changes in the viscosity of the dissolution medium as the polymer dissolves from ibuprofen-PVP solid dispersions. The microviscometer determines the dynamic and kinematic viscosity of liquids based on the rolling/falling ball principle. Using a standard USP dissolution apparatus, the dissolution of the polymer from the solid dispersion was easily measured alongside drug release. Drug release was found to closely follow polymer dissolution at the molecular weights and ratios used. The combination of sensitivity and ease of use make microviscometry a valuable technique for the elucidation of mechanisms governing drug release from polymeric delivery systems.', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '3483', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '29', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => undef, 'volume' => '292', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2005', 'status_changed_hour' => '13', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '8962' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1288953052', 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undef, 'lastmod_month' => '11', 'event_dates' => undef, 'fulltimestamp' => '19960100', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '10', 'number' => '1', 'rev_number' => '6', 'edit_lock_user' => '3483', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '0', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'Q1', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '36', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '5', 'datestamp_day' => '5', 'abstract' => undef, 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '3483', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '36', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => undef, 'volume' => '42', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '1996', 'status_changed_hour' => '10', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '10145' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1302796065', 'creatorlist' => { '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '10145', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Nep', 'eprintid' => '10145', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'Elijah I.', 'creators_id' => undef } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '4', 'editors_name_honourific' => undef, 'admin_note' => 'To email author for post print SJT ', 'event_title' => undef, 'date_type' => 'published', 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2011', 'fileinfo' => '', 'status_changed_second' => '31', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'Physicochemical characterization of grewia polysaccharide gum: Effect of drying method', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/01/01/45', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'none', 'lastmod_minute' => '50', 'refereed' => 'TRUE', 'contact_email' => undef, 'copyright_holders' => undef, 'date_day' => undef, 'gscholar_impact' => undef, 'official_url' => 'http://dx.doi.org/10.1016/j.carbpol.2010.12.005', 'succeeds' => undef, 'datestamp_month' => '4', 'commentary' => undef, 'lastmod_day' => '14', 'publisher' => 'Elsevier', 'pagerange' => '446-453', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2011', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'Carbohydrate Polymers', 'lastmod_second' => '31', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '01448617', 'datestamp_hour' => '15', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '31', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 2, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '10145', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2011', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '4', 'event_dates' => undef, 'fulltimestamp' => '20110200', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '15', 'number' => '1', 'rev_number' => '8', 'edit_lock_user' => '6', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '0', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'Q1', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '50', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '14', 'datestamp_day' => '14', 'abstract' => 'Grewia polysaccharide gum, a potential pharmaceutical excipient was extracted from the inner stem bark of Grewia mollis, thereupon drying was achieved by three techniques: air-drying, freeze-drying and spray-drying. Analysis of the monosaccharide composition including 1H and 13C NMR spectroscopic analysis of the polysaccharide gum was carried out. The effect of the drying methods on the physicochemical properties of the gum was evaluated by Fourier transformed infra-red (FT-IR) spectroscopy, solid-state 13C nuclear magnetic resonance (NMR) spectroscopy, X-ray photoelectron spectroscopy (XPS), thermogravimetric analysis, differential scanning calorimetry and gel permeation chromatography. Monosaccharide sugar analysis revealed that the gum is composed of glucose, rhamnose, galactose, arabinose and xylose as the main neutral sugars. These were supported by the results from 1H and 13C NMR spectroscopic analysis. FT-IR and solid-state NMR results indicated that drying technique has little effect on the structure of the polysaccharide gum but XPS showed that surface chemistry of the gum varied with drying methods. Thermogravimetric analyses showed that oxidation onset varied according to the drying method. The molecular weight was also dependent on the drying technique. For industrial extrapolation, air-drying may be preferable to spray-drying and freeze-drying when relative cost, product stability and powder flow are required, for example in tablet formulation. ', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '6', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '50', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => 'doi:10.1016/j.carbpol.2010.12.005', 'volume' => '84', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2011', 'status_changed_hour' => '15', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '21512' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1410440008', 'creatorlist' => { '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Šupuk', 'eprintid' => '21512', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'Enes', 'creators_id' => 'e.supuk@hud.ac.uk' }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Ghori', 'eprintid' => '21512', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'Muhammad U.', 'creators_id' => undef }, '2' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '21512', 'creators_name_honourific' => '', 'pos' => '2', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '9', 'editors_name_honourific' => undef, 'admin_note' => undef, 'event_title' => undef, 'date_type' => 'published', 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2014', 'fileinfo' => '/style/images/fileicons/application_pdf.png;/21512/1/ConwayTriboEJPS_2014.pdf', 'status_changed_second' => '1', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'Tribo-electric Charging and Adhesion of Cellulose Ethers and their Mixtures with Flurbiprofen', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/02/15/12', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'inpress', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'public', 'lastmod_minute' => '54', 'refereed' => 'TRUE', 'contact_email' => 'e.supuk@hud.ac.uk', 'copyright_holders' => undef, 'date_day' => undef, 'gscholar_impact' => undef, 'official_url' => 'http://dx.doi.org/10.1016/j.ejps.2014.08.010', 'succeeds' => undef, 'datestamp_month' => '9', 'commentary' => undef, 'lastmod_day' => '11', 'publisher' => 'Elsevier', 'pagerange' => undef, 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2014', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'European Journal of Pharmaceutical Sciences', 'lastmod_second' => '5', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '0928-0987', 'datestamp_hour' => '8', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '1', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => undef, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '21512', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2014', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '9', 'event_dates' => undef, 'fulltimestamp' => '20140000', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '12', 'number' => undef, 'rev_number' => '9', 'edit_lock_user' => '6', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '0', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'Q1', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '48', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '10', 'datestamp_day' => '10', 'abstract' => 'The pervasiveness of tribo-electric charge during pharmaceutical processing can lead to the exacerbation of a range of problems including segregation, content heterogeneity and particle surface adhesion. The excipients, hydroxypropyl methylcellulose and methylcellulose, are often used in drug delivery systems and so it is important to understand the impact of associated factors on their charging and adhesion mechanisms, however, little work has been done. Such phenomena become more prominent when excipients are introduced to a powder mixture alongside the active pharmaceutical ingredient(s) (APIs) with inter- and intra-particulate interactions giving rise to electrification and surface adhesion of powder particles. The aim of this study was to understand the impact of material attributes (particle size, hydroxypropyl (Hpo) to methoxyl (Meo) ratio and molecular size) on the charging and adhesion characteristics of cellulose ethers. Furthermore, poorly compactible and highly electrostatically charged drug, flurbiprofen, was used to develop binary powder mixtures having different polymer to drug levels. Subsequently, a relationship between tribo-electric charging and surface adhesion was studied. Charge was induced on powder particles and measured using a custom built device based on a shaking concept consisting of a Faraday cup connected to electrometer. The diversity in physicochemical properties has shown a significant impact on the tribo-electric charging and adhesion behaviour of MC and HPMC. Moreover, the adhesion and electrostatic charge of the API was significantly reduced when MC and HPMC were incorporated. Moreover, tribo-electric charging shows a linear relationship (R2= 0.81-0.98) with particle surface adhesion, however, other factors were also involved. It is anticipated that such reduction in charge and particle surface adhesion would improve flow and compaction properties during processing. ', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '11131', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '48', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => '10.1016/j.ejps.2014.08.010', 'volume' => undef, 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2014', 'status_changed_hour' => '8', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '20277' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1404979757', 'creatorlist' => { '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Alba', 'eprintid' => '20277', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'Katerina', 'creators_id' => undef }, '4' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Kontogiorgos', 'eprintid' => '20277', 'creators_name_honourific' => '', 'pos' => '4', 'creators_name_given' => 'Vassilis', 'creators_id' => undef }, '3' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '20277', 'creators_name_honourific' => '', 'pos' => '3', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Ghori', 'eprintid' => '20277', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'Muhammad U.', 'creators_id' => undef }, '2' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Smith', 'eprintid' => '20277', 'creators_name_honourific' => '', 'pos' => '2', 'creators_name_given' => 'Alan M.', 'creators_id' => 'a.m.smith@hud.ac.uk' } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '5', 'editors_name_honourific' => undef, 'admin_note' => 'Emailed for FT 20/5/14', 'event_title' => undef, 'date_type' => undef, 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2014', 'fileinfo' => '', 'status_changed_second' => '34', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'Okra Extracts In Pharmaceutical And Food Applications', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/02/02/77', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'inpress', 'item_issues_count' => '1', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'none', 'lastmod_minute' => '9', 'refereed' => 'TRUE', 'contact_email' => 'a.m.smith@hud.ac.uk', 'copyright_holders' => undef, 'date_day' => undef, 'gscholar_impact' => undef, 'official_url' => 'http://dx.doi.org/10.1016/j.foodhyd.2014.04.024', 'succeeds' => undef, 'datestamp_month' => '5', 'commentary' => undef, 'lastmod_day' => '10', 'publisher' => 'Elsevier', 'pagerange' => undef, 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2014', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'Food Hydrocolloids', 'lastmod_second' => '34', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '0268005X', 'datestamp_hour' => '15', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '34', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => undef, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '20277', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2014', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '7', 'event_dates' => undef, 'fulltimestamp' => '20140000', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '8', 'number' => undef, 'rev_number' => '11', 'edit_lock_user' => '6', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '0', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'Q1', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '43', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '20', 'datestamp_day' => '20', 'abstract' => 'The potential of okra extract was evaluated for uses in pharmaceutical and food applications. Okra polysaccharides were extracted and dried using different drying procedures (oven drying and freeze-drying). The extracts were examined by means of measurement of swelling and dissolution behaviour of okra extract-based hydrophilic matrices for controlled drug release and emulsification capacity of n-hexadecane. Drying technique and solubility of drugs used were shown to have a significant impact on the swelling and dissolution of the hydrophilic matrix tablets prepared. It was shown that the oven-dried extracts increased swelling of the matrices by approximately 20% compared with freeze dried extracts, resulting in slower drug release. The relative drug solubility also contributed to the extent of swelling and drug release with poorly soluble flurbiprofen reducing the swelling and the release rate when compared with freely soluble theophylline. The emulsification capacity of the okra extracts was also investigated and they were found to emulsify n-hexadecane at pH 3.0. The emulsions produced had an average droplet size of ?6 ?m rising to ?23 ?m after 5 days then remaining relatively constant following 30 days of storage. These results highlight the potential of okra polysaccharide as an alternative sources to fabricate hydrophilic matrix tablets or as stabilisers of emulsions that can be used to deliver drugs or nutrients.', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '8591', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '43', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => 'doi:10.1016/j.foodhyd.2014.04.024', 'volume' => undef, 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2014', 'status_changed_hour' => '15', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '8934' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' 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Therapies that are retained within the oral cavity for both local and systemic action have been utilized for many years, although delivery to the esophagus has been far less reported. Esophageal disease states, including infections, motility disorders, gastric reflux, and cancers, would all benefit from localized drug delivery. Therefore, research in this area provides significant opportunities. The key limitation to effective drug delivery within the esophagus is sufficient retention at this site coupled with activity profiles to correspond with these retention times; therefore, a suitable formulation needs to provide the drug in a ready-to-work form at the site of action during the rapid transit through this organ. A successfully designed esophageal-targeted system can overcome these obstacles. 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Emerging systems that can be used to target the esophagus are reported within this review, as well as the potential of alternative formulations that offer benefits in this exciting area', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '3483', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '12', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => undef, 'volume' => '25', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2008', 'status_changed_hour' => '11', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '8953' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1288947144', 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The microspheres, consisting of poly( )lactide, poly( )lactide, poly( )lactide-co-glycolide, polyhydroxybutyrate of various molecular weights and polyhydroxybutyrate-co-valerate, were characterised for their size distribution, drug loading, release kinetics, surface morphology and hydrophobicity. The influence of these properties on the dynamics of the immune response, following i.m. administration, was studied. The hydrophobic nature of polyhydroxybutyrate microspheres, compared with those formed using polylactides was confirmed and the generation of a significant immune response was delayed using these preparations. Also, the time course of immune responses generated using a range of polyhydroxybutyrate molecular weights was examined. 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The use of the USP III Apparatus', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/01/63/83', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'public', 'lastmod_minute' => '59', 'refereed' => 'TRUE', 'contact_email' => 'k.asare-addo@hud.ac.uk', 'copyright_holders' => undef, 'date_day' => undef, 'gscholar_impact' => undef, 'official_url' => 'http://dx.doi.org/10.1016/j.colsurfb.2012.11.020', 'succeeds' => undef, 'datestamp_month' => '12', 'commentary' => undef, 'lastmod_day' => '7', 'publisher' => 'Elsevier', 'pagerange' => '54-60', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2012', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'Colloids and Surfaces B: Biointerfaces', 'lastmod_second' => '38', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '0927-7765', 'datestamp_hour' => '13', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '0', 'note' => 'NOTICE: this is the author’s version of a work that was accepted for publication in Colloids and Surfaces B: Biointerfaces. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Colloids and Surfaces B: Biointerfaces http://dx.doi.org.libaccess.hud.ac.uk/10.1016/j.colsurfb.2012.11.020', 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 4, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '16383', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2013', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '2', 'event_dates' => undef, 'fulltimestamp' => '20130400', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '9', 'number' => undef, 'rev_number' => '16', 'edit_lock_user' => '6', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '3', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'RS', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '37', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '18', 'datestamp_day' => '18', 'abstract' => 'Theophylline extended release (ER) matrices containing hypromellose (hydroxypropyl methylcellulose (HPMC) E4 M and K4 M were evaluated in media with a pH range of 1.2-7.5, using an automated USP type III, Bio-Dis dissolution apparatus. The objectives of this study were to evaluate the effects of systematic agitation,ionic strength and pH on the release of theophylline from the gel forming hydrophilic polymeric matrices with different methoxyl substitution levels.Tribo-electric charging of hypromellose, theophylline and their formulated blends containing E4 M and K4 M grades has been characterised, along with quantitative observations of flow, compression behaviour and particle morphology. Agitations were studied at 5, 10, 15, 20, 25, 30 dips per minute (dpm) and also in the ascending and descending order in the dissolution vials.The ionic concentration strength of the media was also varied over a range of 0-0.4 M to simulate the gastrointestinal fed and fasted states and various physiological pH conditions. To study the effect of ionic strength on the hydrophilic matrices, agitation was set at 20 dpm.The charge results on individual components imply that the positively charged particles have coupled with the negatively charged particles to form a stable ordered mixture which is believed to result in a more homogeneous and stable system.The particle shape analysis showed the HPMCK4 M polymer to have a more irregular morphology and a rougher surface texture in comparison to the HPMC E4 M polymer, possibly a contributory factor to the gelation process.The results showed gelation occurred quicker for the K4 M tablet matrices. Drug release increased with increased agitation. This was more pronounced for the E4 M tablet matrices. Theionic strength also had more of an effect on the drug release from the E4 M matrices. The experiments highlighted the resilience of the K4 M matrices in comparison with the E4 M matrices. The results thus show that despite similar viscosities of E4 M and K4 M, the methoxyl substitution makes a difference to their control of drug release and as such care and consideration should be given to the choice of polymer used for extended release. The use of systematic change of agitation method and ionic strength may indicate potential fed and fasted effects on drug release from hydrophilic matrices.', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '11131', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '37', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => '10.1016/j.colsurfb.2012.11.020', 'volume' => '104', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2013', 'status_changed_hour' => '13', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '8945' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1288876335', 'creatorlist' => { '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '8945', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' }, '4' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Batchelor', 'eprintid' => '8945', 'creators_name_honourific' => '', 'pos' => '4', 'creators_name_given' => 'Hannah', 'creators_id' => undef }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Gramaglia', 'eprintid' => '8945', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'D', 'creators_id' => undef }, '3' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Malcolm', 'eprintid' => '8945', 'creators_name_honourific' => '', 'pos' => '3', 'creators_name_given' => 'R', 'creators_id' => undef }, '2' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Kett', 'eprintid' => '8945', 'creators_name_honourific' => '', 'pos' => '2', 'creators_name_given' => 'V', 'creators_id' => undef } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '11', 'editors_name_honourific' => undef, 'admin_note' => undef, 'event_title' => undef, 'date_type' => 'published', 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2010', 'fileinfo' => '', 'status_changed_second' => '32', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'High speed DSC (hyper-DSC) as a tool to measure the solubility of a drug within a solid or semi-solid matrix', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/00/89/45', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'none', 'lastmod_minute' => '22', 'refereed' => 'TRUE', 'contact_email' => undef, 'copyright_holders' => undef, 'date_day' => undef, 'gscholar_impact' => undef, 'official_url' => 'http://dx.doi.org/10.1016/j.ijpharm.2005.04.038', 'succeeds' => undef, 'datestamp_month' => '11', 'commentary' => undef, 'lastmod_day' => '4', 'publisher' => 'Elsevier', 'pagerange' => '1-5', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2010', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'International Journal of Pharmaceutics', 'lastmod_second' => '32', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '0378-5173', 'datestamp_hour' => '13', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '32', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 9, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '8945', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2010', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '11', 'event_dates' => undef, 'fulltimestamp' => '20050900', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '13', 'number' => '1-2', 'rev_number' => '8', 'edit_lock_user' => '3483', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '0', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'Q1', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '22', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '4', 'datestamp_day' => '4', 'abstract' => 'Conventional differential scanning calorimetry (DSC) techniques are commonly used to quantify the solubility of drugs within polymeric-controlled delivery systems. However, the nature of the DSC experiment, and in particular the relatively slow heating rates employed, limit its use to the measurement of drug solubility at the drug's melting temperature. Here, we describe the application of hyper-DSC (HDSC), a variant of DSC involving extremely rapid heating rates, to the calculation of the solubility of a model drug, metronidazole, in silicone elastomer, and demonstrate that the faster heating rates permit the solubility to be calculated under non-equilibrium conditions such that the solubility better approximates that at the temperature of use. At a heating rate of 400 °C/min (HDSC), metronidazole solubility was calculated to be 2.16 mg/g compared with 6.16 mg/g at 20 °C/min. ', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '3483', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '22', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => 'doi:10.1016/j.ijpharm.2005.04.038', 'volume' => '301', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2005', 'status_changed_hour' => '13', 'gscholar_cluster' => undef, 'producers_name_family' => undef }, '8512' => { 'funders' => undef, 'conductors_name_family' => undef, 'num_pieces' => undef, 'department' => undef, 'contributors_id' => undef, 'gscholar_datestamp_second' => undef, 'keywords' => undef, 'lyricists_name_lineage' => undef, 'lyricists_id' => undef, 'edit_lock_since' => '1316003359', 'creatorlist' => { '1' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Worthington', 'eprintid' => '8512', 'creators_name_honourific' => '', 'pos' => '1', 'creators_name_given' => 'T.', 'creators_id' => undef }, '0' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Hendry', 'eprintid' => '8512', 'creators_name_honourific' => '', 'pos' => '0', 'creators_name_given' => 'E. R.', 'creators_id' => undef }, '3' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Lambert', 'eprintid' => '8512', 'creators_name_honourific' => '', 'pos' => '3', 'creators_name_given' => 'P.A.', 'creators_id' => undef }, '2' => { 'creators_name_lineage' => '', 'creators_name_family' => 'Conway', 'eprintid' => '8512', 'creators_name_honourific' => '', 'pos' => '2', 'creators_name_given' => 'Barbara R', 'creators_id' => 'b.r.conway@hud.ac.uk' } }, 'exhibitors_id' => undef, 'latitude' => undef, 'replacedby' => undef, 'status_changed_month' => '9', 'editors_name_honourific' => undef, 'admin_note' => undef, 'event_title' => undef, 'date_type' => 'published', 'pres_type' => undef, 'longitude' => undef, 'creators_name_honourific' => '', 'include_in_hebci' => 'no', 'producers_name_honourific' => undef, 'scopus_citation_count' => undef, 'datestamp_year' => '2010', 'fileinfo' => '', 'status_changed_second' => '53', 'exhibitors_name_honourific' => undef, 'editors_id' => undef, 'title' => 'Antimicrobial efficacy of eucalyptus oil and 1,8-cineole alone and in combination with chlorhexidine digluconate against microorganisms grown in planktonic and biofilm cultures', 'corp_creators' => undef, 'contributors_name_given' => undef, 'alt_title' => undef, 'contributors_name_family' => undef, 'sponsors' => undef, 'output_media' => undef, 'editors_name_lineage' => undef, 'dir' => 'disk0/00/00/85/12', 'overlay_journal_id' => undef, 'gscholar_datestamp_year' => undef, 'ispublished' => 'pub', 'item_issues_count' => '0', 'conductors_name_given' => undef, 'sword_depositor' => undef, 'full_text_status' => 'none', 'lastmod_minute' => '29', 'refereed' => 'TRUE', 'contact_email' => undef, 'copyright_holders' => undef, 'date_day' => undef, 'gscholar_impact' => undef, 'official_url' => 'http://dx.doi.org/10.1093/jac/dkp362', 'succeeds' => undef, 'datestamp_month' => '9', 'commentary' => undef, 'lastmod_day' => '14', 'publisher' => 'Oxford University Press', 'pagerange' => '1219-1225', 'include_in_pedagogical' => 'no', 'task_purpose' => undef, 'status_changed_year' => '2010', 'book_title' => undef, 'thesis_name' => undef, 'event_location' => undef, 'type' => 'article', 'publication' => 'Journal of Antimicrobial Chemotherapy', 'lastmod_second' => '41', 'place_of_pub' => undef, 'contributors_name_honourific' => undef, 'gscholar_datestamp_day' => undef, 'issn' => '0305-7453', 'datestamp_hour' => '12', 'exhibitors_name_given' => undef, 'creators_name_family' => 'Conway', 'composition_type' => undef, 'producers_id' => undef, 'datestamp_second' => '53', 'note' => undef, 'edit_lock_until' => '0', 'editor_note' => undef, 'pedagogic_type' => undef, 'date_month' => 9, 'rights' => undef, 'contributors_type' => undef, 'scopus_id' => undef, 'eprintid' => '8512', 'producers_name_given' => undef, 'thesis_type' => undef, 'projects' => undef, 'lastmod_year' => '2011', 'data_type' => undef, 'gscholar_datestamp_minute' => undef, 'editors_name_given' => undef, 'isbn' => undef, 'include_in_cv' => 'yes', 'editors_name_family' => undef, 'lastmod_month' => '9', 'event_dates' => undef, 'fulltimestamp' => '20090900', 'learning_level' => undef, 'conductors_name_lineage' => undef, 'pages' => undef, 'source' => undef, 'lastmod_hour' => '12', 'number' => '6', 'rev_number' => '9', 'edit_lock_user' => '3483', 'series' => undef, 'creators_name_lineage' => '', 'pos' => '1', 'metadata_visibility' => 'show', 'eprint_status' => 'archive', 'creators_name_given' => 'Barbara R', 'exhibitors_name_lineage' => undef, 'divisions' => 'sas', 'institution' => undef, 'subjects' => 'RM', 'gscholar_datestamp_hour' => undef, 'producers_name_lineage' => undef, 'lyricists_name_given' => undef, 'completion_time' => undef, 'status_changed_minute' => '14', 'conductors_name_honourific' => undef, 'exhibitors_name_family' => undef, 'lyricists_name_honourific' => undef, 'event_type' => undef, 'importid' => undef, 'status_changed_day' => '10', 'datestamp_day' => '10', 'abstract' => 'Objectives Effective disinfection and antisepsis is pivotal in preventing infections within the healthcare setting. Chlorhexidine digluconate (CHG) is a widely used disinfectant/antiseptic possessing broad-spectrum antimicrobial activity; however, its penetration into bacterial biofilms and human skin is poor. The aim of this study was to investigate the antimicrobial efficacy of crude eucalyptus oil (EO) and its main component 1,8-cineole (a recognized permeation enhancer), alone and in combination with CHG, against a panel of clinically relevant microorganisms grown in planktonic and biofilm cultures. Methods MICs and minimum bactericidal/fungicidal concentrations were determined for each microorganism grown in suspension and biofilm using microbroth dilution and ATP bioluminescence, respectively. Chequerboard assays were used to determine synergistic, indifferent or antagonistic interactions between CHG and EO or 1,8-cineole. Results Antimicrobial activity was demonstrated by CHG, EO and 1,8-cineole; however, CHG was significantly more active against microorganisms in both planktonic and biofilm modes of growth (P?<?0.05). Crude EO was significantly more efficacious against microorganisms grown in suspension compared with 1,8-cineole (P?<?0.05). Synergistic activity was demonstrated between CHG and both EO and 1,8-cineole against suspensions of Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), Escherichia coli and Candida albicans, and biofilm cultures of MRSA and Pseudomonas aeruginosa. Conclusions In conclusion, CHG may be combined with either crude EO or its major component 1,8-cineole for enhanced, synergistic antimicrobial activity against a wide range of microorganisms in planktonic and biofilm modes of growth; however, the superior antimicrobial efficacy associated with crude EO alone, compared with 1,8-cineole, favours its combination with CHG. ', 'creators_id' => 'b.r.conway@hud.ac.uk', 'contributors_name_lineage' => undef, 'userid' => '3483', 'patent_applicant' => undef, 'monograph_type' => undef, 'datestamp_minute' => '14', 'lyricists_name_family' => undef, 'sword_slug' => undef, 'id_number' => 'doi:10.1093/jac/dkp362', 'volume' => '64', 'gscholar_datestamp_month' => undef, 'conductors_id' => undef, 'suggestions' => undef, 'referencetext' => undef, 'date_year' => '2009', 'status_changed_hour' => '12', 'gscholar_cluster' => undef, 'producers_name_family' => undef } };

2014

Mahdi, M., Conway, B. and Smith, A. (2014) ‘Evaluation of gellan gum fluid gels as modified release oral liquids International Journal of Pharmaceutics , 475 (1-2), pp. 335-343. ISSN 0378-5173

Kakadia, P. and Conway, B. (2014) ‘Solid Lipid Nanoparticles: A Potential Approach for Dermal Drug DeliveryAmerican Journal of Pharmacological Sciences , 2 (5A).

Adebisi, A. and Conway, B. (2014) ‘Lectin-conjugated microspheres for eradication of Helicobacter pylori infection and interaction with mucusInternational Journal of Pharmaceutics , 470 (1-2), pp. 28-40. ISSN 0378-5173

Ghori, M., Ginting, G., Smith, A. and Conway, B. (2014) ‘Simultaneous quantification of drug release and erosion from hypromellose hydrophilic matricesInternational Journal of Pharmaceutics , 465 (1-2), pp. 405-412. ISSN 0378-5173

Adebisi, A. and Conway, B. (2014) ‘Preparation and characterisation of gastroretentive alginate beads for targeting H. pyloriJournal of Microencapsulation , 31 (1), pp. 58-67. ISSN 0265-2048

Ghori, M., Šupuk, E. and Conway, B. (2014) ‘Tribo-electric Charging and Adhesion of Cellulose Ethers and their Mixtures with FlurbiprofenEuropean Journal of Pharmaceutical Sciences . ISSN 0928-0987

Ghori, M., Alba, K., Smith, A., Conway, B. and Kontogiorgos, V. (2014) ‘Okra Extracts In Pharmaceutical And Food ApplicationsFood Hydrocolloids . ISSN 0268005X

2013

Šupuk, E., Ghori, M., Asare-Addo, K., Laity, P., Panchmatia, P. and Conway, B. (2013) ‘The influence of salt formation on electrostatic and compression properties of flurbiprofen saltsInternational Journal of Pharmaceutics , 458 (1), pp. 118-127. ISSN 0378-5173

Asare-Addo, K., Conway, B., Larhrib, H., Levina, M., Rajabi-Siahboomi, A., Tetteh, J., Boateng, J. and Nokhodchi, A. (2013) ‘The effect of pH and ionic strength of dissolution media on in-vitro release of two model drugs of different solubilities from HPMC matricesColloids and Surfaces B: Biointerfaces , 111, pp. 384-391. ISSN 0927-7765

Asare-Addo, K., Conway, B., Hajamohaideen, M., Kaialy, W., Nokhodchi, A. and Larhrib, E. (2013) ‘Aqueous And Hydro-Alcoholic Media Effects On PolyolsColloids and Surfaces B: Biointerfaces , 111, pp. 24-29. ISSN 0927-7765

Asare-Addo, K., Kaialy, W., Levina, M., Rajabi-Siahboomi, A., Ghori, M., Šupuk, E., Laity, P., Conway, B. and Nokhodchi, A. (2013) ‘The influence of agitation sequence and ionic strength on in vitro drug release from hypromellose (E4M and K4M) ER matrices--the use of the USP III apparatus.Colloids and Surfaces B: Biointerfaces , 104, pp. 54-60. ISSN 0927-7765

Asare-Addo, K., Kaialy, W., Levina, M., Rajabi-Siahboomi, A., Ghori, M., Šupuk, E., Laity, P., Conway, B. and Nokhodchi, A. (2013) ‘The Influence of Agitation Sequence and Ionic Strength on in-vitro Drug Release from Hypromellose (E4 M and K4 M) ER Matrices - The use of the USP III ApparatusColloids and Surfaces B: Biointerfaces , 104, pp. 54-60. ISSN 0927-7765

Ousey, K., Atkinson, R., Fleming, L. and Conway, B. (2013) ‘Academia and clinical practice – working together successfully to develop skin integrity knowledge and skillsJournal of Community Nursing , 27 (1). ISSN 0140-0908

2012

Hendry, E., Conway, B. and Worthington, T. (2012) ‘Antimicrobial efficacy of a novel eucalyptus oil, chlorhexidine digluconate and isopropyl alcohol biocide formulation.International Journal of Molecular Sciences , 13 (11), pp. 14016-14025. ISSN 1422-0067

Hendry, E., Conway, B. and Worthington, T. (2012) ‘Digluconate and Isopropyl Alcohol Biocide FormulationInternational Journal of Molecular Sciences , 13 (11), pp. 14016-14025. ISSN 1422-0067

Nep, E. and Conway, B. (2012) ‘Preformulation studies on grewia gum as a formulation excipientJournal of Thermal Analysis and Calorimetry , 108 (1), pp. 197-205. ISSN 1388-6150

David, S., Timmins, P. and Conway, B. (2012) ‘Impact of the counterion on the solubility and physicochemical properties of salts of carboxylic acid drugsDrug Development and Industrial Pharmacy , 38 (1), pp. 93-103. ISSN 0363-9045

2011

Nep, E. and Conway, B. (2011) ‘Grewia Gum 1: Some Mechanical and Swelling Properties of Compact and FilmTropical Journal of Pharmaceutical Research , 10 (4), pp. 385-392. ISSN 1596-5996

Adebisi, A. and Conway, B. (2011) ‘Gastroretentive microparticles for drug delivery applicationsJournal of Microencapsulation , 28 (8), pp. 689-708. ISSN 0265-2048

Nep, E. and Conway, B. (2011) ‘Grewia Gum 2: Mucoadhesive Properties of Compacts and GelsTropical Journal of Pharmaceutical Research , 10 (4), pp. 393-401. ISSN 1596-5996

Karpanen, T., Casey, A., Conway, B., Lambert, P. and Elliott, T. (2011) ‘Antimicrobial activity of a chlorhexidine intravascular catheter site gel dressingJournal of Antimicrobial Chemotherapy , 66 (8), pp. 1777-1784. ISSN 0305-7453

Nep, E. and Conway, B. (2011) ‘Evaluation of grewia polysaccharide gum as a suspending agentInternational Journal of Pharmacy and Pharmaceutical Sciences , 3 (2), pp. 168-173. ISSN 0975-1491

Nep, E. and Conway, B. (2011) ‘Physicochemical characterization of grewia polysaccharide gum: Effect of drying methodCarbohydrate Polymers , 84 (1), pp. 446-453. ISSN 01448617

Nep, E. and Conway, B. (2011) ‘Grewia polysaccharide as a pharmaceutical excipient in matrix tabletsJournal of Excipients and Food Chemicals , 2 (1), pp. 3-15. ISSN 2150-2668

2010

David, S., Ramirez, M., Timmins, P. and Conway, B. (2010) ‘Comparative physical, mechanical and crystallographic properties of a series of gemfibrozil saltsJournal of Pharmacy and Pharmacology , 62 (11), pp. 1519-1525. ISSN 2042-7158

Nep, E. and Conway, B. (2010) ‘Polysaccharide gum matrix tablets for oral controlled delivery of CimetidineJournal of Pharmaceutical Sciences and Research , 2 (11), pp. 708-716. ISSN 0975-1459

Karpanen, T., Conway, B., Worthington, T., Hilton, A., Elliott, T. and Lambert, P. (2010) ‘Enhanced chlorhexidine skin penetration with eucalyptus oilBMC Infectious Diseases , 10 (278), pp. 1-6. ISSN 1471-2334

Schwalbe, C., Ramirez, M., Conway, B., Bache, C., Coles, S. and Timmins, P. (2010) ‘Structure and properties of (hydroxy)alkylammonium salts of flurbiprofen’. In: Transactions of the Symposium held at the 2010 American Crystallographic Association Annual Meeting. : American Crystallographic Association. .

Karpanen, T., Hendry, E., Worthington, T., Lambert, P. and Conway, B. (2010) ‘Chlorhexidine : skin permeation and antisepsisIndustrial pharmacy , 26, pp. 11-14. ISSN 1741-4911

Nep, E. and Conway, B. (2010) ‘Characterization of grewia gum, a potential pharmaceutical excipientJournal of Excipients and Food Chemicals , 1 (1), pp. 30-40. ISSN 2150-2668

2009

Hendry, E., Worthington, T., Conway, B. and Lambert, P. (2009) ‘Antimicrobial efficacy of eucalyptus oil and 1,8-cineole alone and in combination with chlorhexidine digluconate against microorganisms grown in planktonic and biofilm culturesJournal of Antimicrobial Chemotherapy , 64 (6), pp. 1219-1225. ISSN 0305-7453

Karpanen, T., Worthington, T., Conway, B., Hilton, A., Elliott, T. and Lambert, P. (2009) ‘Permeation of Chlorhexidine from Alcoholic and Aqueous Solutions within Excised Human SkinAntimicrobial Agents and Chemotherapy , 53 (4), pp. 1717-1719. ISSN 0066-4804

2008

Karpanen, T., Worthington, T., Hendry, E., Conway, B. and Lambert, P. (2008) ‘Antimicrobial efficacy of chlorhexidine digluconate alone and in combination with eucalyptus oil, tea tree oil and thymol against planktonic and biofilm cultures of Staphylococcus epidermidisJournal of Antimicrobial Chemotherapy , 62 (5), pp. 1031-1036. ISSN 0305-7453

Karpanen, T., Worthington, T., Conway, B., Hilton, A., Elliott, T. and Lambert, P. (2008) ‘Penetration of Chlorhexidine into Human SkinAntimicrobial Agents and Chemotherapy , 52 (10), pp. 3633-3636. ISSN 0066-4804

Conway, B (2008) ‘Delivering scents and flavours - lessons from the pharmaceutical industry Chimica Oggi , 26 (3), pp. 28-29. ISSN 0392-839X

Zhang, L., Russell, D., Conway, B. and Batchelor, H. (2008) ‘Strategies and Therapeutic Opportunities for the Delivery of Drugs to the EsophagusCritical Reviews in Therapeutic Drug Carrier Systems , 25 (3), pp. 259-304. ISSN 0743-4863

Conway, B (2008) ‘Recent Patents on Ocular Drug Delivery Systems Recent Patents on Drug Delivery & Formulation , 2 (1), pp. 1-8. ISSN 1872-2113

2007

Conway, B (2007) ‘The sticky solution to drug deliveryWorld pharmaceutical frontiers , pp. 87-89.

Suppasansatorn, P., Nimmannit, U., Conway, B., Du, L. and Wang, Y. (2007) ‘Microemulsions as topical delivery vehicles for the anti-melanoma prodrug, temozolomide hexyl ester (TMZA-HE)Journal of Pharmacy and Pharmacology , 59 (6), pp. 787-794. ISSN 0022-3573

Cheung, E., David, S., Harris, K., Conway, B. and Timmins, P. (2007) ‘Structural properties of a family of hydrogen-bonded co-crystals formed between gemfibrozil and hydroxy derivatives of t-butylamine, determined directly from powder X-ray diffraction dataJournal of Solid State Chemistry , 180 (3), pp. 1068-1075. ISSN 0022-4596

2006

Suppasansatorn, P., Wang, G., Conway, B., Wang, W. and Wang, Y. (2006) ‘Skin delivery potency and antitumor activities of temozolomide ester prodrugsCancer Letters , 244 (1), pp. 42-52. ISSN 0304-3835

2005

Gramaglia, D., Conway, B., Kett, V., Malcolm, R. and Batchelor, H. (2005) ‘High speed DSC (hyper-DSC) as a tool to measure the solubility of a drug within a solid or semi-solid matrixInternational Journal of Pharmaceutics , 301 (1-2), pp. 1-5. ISSN 0378-5173

Shaw, L., Irwin, W., Grattan, T. and Conway, B. (2005) ‘The Effect of Selected Water-Soluble Excipients on the Dissolution of Paracetamol and IbuprofenDrug Development and Industrial Pharmacy , 31 (6), pp. 515-525. ISSN 0363-9045

Esnaashari, S., Javadzadeh , Y., Batchelor, H. and Conway, B. (2005) ‘The use of microviscometry to study polymer dissolution from solid dispersion drug delivery systemsInternational Journal of Pharmaceutics , 292 (1-2), pp. 227-230. ISSN 0378-5173

Shaw, L., Irwin, W., Grattan, T. and Conway, B. (2005) ‘The influence of excipients on the diffusion of ibuprofen and paracetamol in gastric mucusInternational Journal of Pharmaceutics , 290 (1-2), pp. 145-154. ISSN 0378-5173

Conway, B (2005) ‘Drug delivery strategies for the Treatment of Helicobacter pylori infection Current Pharmaceutical Design , 11 (6), pp. 775-790. ISSN 1381-6128

2004

Morjaria, Y., Irwin, W., Barnett, P., Chan, R. and Conway, B. (2004) ‘In vitro release of nicotine from chewing gum formulationsDissolution Technologies , 11 (2), pp. 12-15. ISSN 1521-298X

Morjaria, Y., Irwin, W., Barnett, P., Chan, R. and Conway, B. (2004) ‘Chewing gum as a drug delivery systemDrug delivery systems and sciences , 4 (1), pp. 11-15. ISSN 1472-4715

2003

Conway, B (2003) Chewing gum as a drug delivery system PharmaDeals

Lambert, P. and Conway, B. (2003) ‘Pharmaceutical quality of ceftriaxone generic drug products compared with rocephinJournal of Chemotherapy , 15 (4), pp. 402-413. ISSN 1120-009X

2002

Shaw, L., Irwin, W., Grattan, T. and Conway, B. (2002) ‘The development of a modified dissolution method suitable for investigating powder mixturesDrug Development and Industrial Pharmacy , 28 (9), pp. 1147-1153. ISSN 0363-9045

Rostami-Hodjegan, A., Shiran, M., Tucker, G., Conway, B., Irwin, W., Shaw, L. and Grattan, T. (2002) ‘A New Rapidly Absorbed Paracetamol Tablet Containing Sodium Bicarbonate. II. Dissolution Studies and In Vitro/In Vivo CorrelationDrug Development and Industrial Pharmacy , 28 (5), pp. 533-543. ISSN 0363-9045

Tran, C., Timmins, P., Conway, B. and Irwin, W. (2002) ‘Investigation of the coordinated functional activities of cytochrome P450 3A4 and P-glycoprotein in limiting the absorption of xenobiotics in Caco-2 cellsJournal of Pharmaceutical Sciences , 91 (1), pp. 117-128. ISSN 0022-3549

1998

Griffin, K., Conway, B., Alpar, H. and Williamson, E. (1998) ‘Immune responses to V antigen of Yersinia pestis co-encapsulated with IFN-y;: effect of dose and formulationVaccine , 16 (5), pp. 517-521. ISSN 0264-410X

1997

Conway, B., Eyles, J. and Alpar, H. (1997) ‘A comparative study on the immune responses to antigens in PLA and PHB microspheresJournal of Controlled Release , 49 (1), pp. 1-9. ISSN 0168-3659

Eyles, J., Alpar, H., Conway, B. and Keswick, M. (1997) ‘Oral delivery and fate of PLA microencapsulated interferonJournal of Pharmacy and Pharmacology , 49, pp. 669-674. ISSN 0022-3573

Conway, B. and Alpar, H. (1997) ‘Single and Coencapsulation of lnterferon-? in Biodegradable PLA Microspheres for Optimization of Multicomponent Vaccine Delivery VehiclesDrug Delivery , 4 (2), pp. 75-80. ISSN 1071-7544

1996

Conway, B. and Alpar, H. (1996) ‘Co-encapsulation of proteins into PLA microspheresPharmaceutical sciences , 2 (4), pp. 173-176. ISSN 1460-8081

Conway, B. and Alpar, H. (1996) ‘Double emulsion encapsulation of proteins as model antigens using polylactide polymers : effect of emulsifier on the microsphere characteristics and release kineticsEuropean Journal of Pharmaceutics and Biopharmaceutics , 42 (1), pp. 42-48. ISSN 0939-6411

Research Degree Supervision

Pharmaceutical salt formation and characterisation

Salt formation has been studied extensively as a strategy to improve drug solubility and a range of different counterions can be used. This modification will also alter the mechanical properties of a drug and the type of counterion will be important in determining those properties. A better understanding of which factors of the solid state can have an influence in the mechanical properties of pharmaceutical powders can help to optimise and reduce cost of tablet manufacturing. The aim of this project is to form different series of salts of poorly soluble and poorly compressible acidic drugs and to establish predictive relationships between architectural characteristics and physicochemical and mechanical properties of the salts.

Skin antisepsis

Appropriate skin antisepsis to reduce the number of microorganisms on the skin prior to carrying out an invasive procedure is critical, as it decreases the risk of subsequent infection. However, skin antisepsis does not eradicate all the microorganisms associated with the skin. This is probably related to the limited skin permeation of antiseptics and the presence of microorganisms residing in the deeper layers of the skin. This aim of this project is to develop formulations better designed to target these sites within the skin.

Development of oromucosal drug delivery systems

Targeting the buccal mucosa can be an effective route for drug absorption avoiding complications associated with conventional oral delivery systems. In order to facilitate absorption, the drug must be presented to the mucosa in an absorbable state from a dosage form that can enhance uptake by this route. Using a range of in vitro techniques, this project will focus on strategies to enhance buccal absorption. Correlation between rates of release and buccal absorption will be developed for a range of dosage forms.

Nonaparticulates for drug delivery

Nanoparticles can be used for targeted drug delivery, to improve bioavailability, to prolong drug release, and to enhance the dissolution of drugs with limited aqueous solubility. Penetration of drugs applied to the skin may occur via the stratum corneum or by the skin appendages such as sweat glands and hair follicles. Recent studies have shown that the hair follicles can be targeted using nanoparticles and this project will involve the development and characterisation of follicular delivery systems.

Last updated Thursday 6 March 2014
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